Product References
Gut-derived β-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis.
Gut microbes
Jin J,Xu Z,Zhang L,Zhang C,Zhao X,Mao Y,Zhang H,Liang X,Wu J,Yang Y,Zhang J
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Western Blot
Tue Jan 24 00:00:00 EST 2023
Activation of the hypoxia response protects mice from amyloid-β accumulation.
Cellular and molecular life sciences : CMLS
Ollonen T,Kurkela M,Laitakari A,Sakko S,Koivisto H,Myllyharju J,Tanila H,Serpi R,Koivunen P
PA1-757 was used in Western Blotting to suggest that non-full-scale activation of the HIF pathway appears to mediate protection against neurodegeneration via several mechanisms and should be studied as a treatment option for AD.
Tue Jul 19 00:00:00 EDT 2022
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus.
EBioMedicine
Lee JH,Ostalecki C,Oberstein T,Schierer S,Zinser E,Eberhardt M,Blume K,Plosnita B,Stich L,Bruns H,Coras R,Vera-Gonzales J,Maler M,Baur AS
PA1-757 was used in Western Blot to conclude that protease-containing pEV could be part of a communication axis between the periphery and the brain that could be become detrimental depending on pEV concentration and duration of target cell impact.
Tue Mar 01 00:00:00 EST 2022
Alzheimer's disease protease-containing plasma extracellular vesicles transfer to the hippocampus via the choroid plexus.
EBioMedicine
Lee JH,Ostalecki C,Oberstein T,Schierer S,Zinser E,Eberhardt M,Blume K,Plosnita B,Stich L,Bruns H,Coras R,Vera-Gonzales J,Maler M,Baur AS
PA1-757 was used in Western Blot to conclude that protease-containing pEV could be part of a communication axis between the periphery and the brain that could be become detrimental depending on pEV concentration and duration of target cell impact.
Tue Mar 01 00:00:00 EST 2022
The novel anti-colitic effect of β-adrenergic receptors via modulation of PS1/BACE-1/Aβ axis and NOTCH signaling in an ulcerative colitis model.
Frontiers in pharmacology
Nasser S,Abdallah DM,Ahmed KA,Abdel-Mottaleb Y,El-Abhar HS
PA1-757 was used in Western Blotting to investigate the impact of mirabegron (β3-agonist) and/or carvedilol (β1/β2 antagonist) on iodoacetamide-induced ulcerative colitis with emphasis on the novel pathomechanism of the PS1/BACE-1/Aβ axis in ulcerative colitis, and its relation to the inflammatory cascade, fibrotic processes, and the gut barrier dysfunction.
Fri Nov 18 00:00:00 EST 2022
Amyloidogenic Processing of Amyloid Precursor Protein Drives Stretch-Induced Disruption of Axonal Transport in hiPSC-Derived Neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Chaves RS,Tran M,Holder AR,Balcer AM,Dickey AM,Roberts EA,Bober BG,Gutierrez E,Head BP,Groisman A,Goldstein LSB,Almenar-Queralt A,Shah SB
PA1-757 was used in Immunocytochemistry to reveal potential subcellular pathways contributing to the development of AD-associated phenotypes following mild traumatic brain injury, and putative strategies for intervening in these pathways.
Wed Dec 08 00:00:00 EST 2021
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Acta neuropathologica communications
Jeong A,Cheng S,Zhong R,Bennett DA,Bergö MO,Li L
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Western Blot
Tue Jul 27 00:00:00 EDT 2021
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Acta neuropathologica communications
Jeong A,Cheng S,Zhong R,Bennett DA,Bergö MO,Li L
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Western Blot
Tue Jul 27 00:00:00 EDT 2021
Upregulation of APP endocytosis by neuronal aging drives amyloid-dependent synapse loss.
Journal of cell science
Burrinha T,Martinsson I,Gomes R,Terrasso AP,Gouras GK,Almeida CG
PA1-757 was used in Western Blot to identify APP endocytosis upregulation as a potential mechanism of neuronal aging and, thus, a novel target to prevent late-onset Alzheimer's disease.
Sat May 01 00:00:00 EDT 2021
A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor.
The Journal of cell biology
Liu L,Ding L,Rovere M,Wolfe MS,Selkoe DJ
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Immunoprecipitation
Mon Feb 04 00:00:00 EST 2019
A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor.
The Journal of cell biology
Liu L,Ding L,Rovere M,Wolfe MS,Selkoe DJ
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Immunoprecipitation
Mon Feb 04 00:00:00 EST 2019
Bin1 and CD2AP polarise the endocytic generation of beta-amyloid.
EMBO reports
Ubelmann F,Burrinha T,Salavessa L,Gomes R,Ferreira C,Moreno N,Guimas Almeida C
PA1757 was used in immunocytochemistry to demonstrate that Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites
Sun Jan 01 00:00:00 EST 2017
Bin1 and CD2AP polarise the endocytic generation of beta-amyloid.
EMBO reports
Ubelmann F,Burrinha T,Salavessa L,Gomes R,Ferreira C,Moreno N,Guimas Almeida C
PA1757 was used in immunocytochemistry to demonstrate that Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites
Sun Jan 01 00:00:00 EST 2017
Bin1 and CD2AP polarise the endocytic generation of beta-amyloid.
EMBO reports
Ubelmann F,Burrinha T,Salavessa L,Gomes R,Ferreira C,Moreno N,Guimas Almeida C
PA1757 was used in immunocytochemistry to demonstrate that Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites
Sun Jan 01 00:00:00 EST 2017
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Neurobiology of disease
Natunen T,Takalo M,Kemppainen S,Leskelä S,Marttinen M,Kurkinen KMA,Pursiheimo JP,Sarajärvi T,Viswanathan J,Gabbouj S,Solje E,Tahvanainen E,Pirttimäki T,Kurki M,Paananen J,Rauramaa T,Miettinen P,Mäkinen P,Leinonen V,Soininen H,Airenne K,Tanzi RE,Tanila H,Haapasalo A,Hiltunen M
PA1-757 was used in western blot to compare the relationship between BACE1 and ubiquilin-1 in human Alzheimer's disease, APdE9 transgenic mouse brain and cell-based models
Fri Jan 01 00:00:00 EST 2016
Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.
Biochemistry
Wang H,Sang N,Zhang C,Raghupathi R,Tanzi RE,Saunders A
PA1-757 was used in Western Blotting to identify the novel amyloid precursor protein c-terminal fragments, which accumulated following cathepsin L inhibition.
Tue May 12 00:00:00 EDT 2015
Cathepsin L Mediates the Degradation of Novel APP C-Terminal Fragments.
Biochemistry
Wang H,Sang N,Zhang C,Raghupathi R,Tanzi RE,Saunders A
PA1-757 was used in Western Blotting to identify the novel amyloid precursor protein c-terminal fragments, which accumulated following cathepsin L inhibition.
Tue May 12 00:00:00 EDT 2015
Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease.
Journal of Alzheimer's disease : JAD
Natunen T,Parrado AR,Helisalmi S,Pursiheimo JP,Sarajärvi T,Mäkinen P,Kurkinen KM,Mullin K,Alafuzoff I,Haapasalo A,Bertram L,Soininen H,Tanzi RE,Hiltunen M
PA1-757 was used in western blot to study whether the BACE1-modulator GGA3 contributes to Alzheimer's disease pathology
Tue Apr 08 00:00:00 EDT 2014
Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Walker KR,Kang EL,Whalen MJ,Shen Y,Tesco G
PA1-757 was used in western blot to study the role of GGA1 and GGA3 in the elevation of BACE1 in the acute phase after injury
Wed Jul 25 00:00:00 EDT 2012
Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.
Biology open
Steuble M,Diep TM,Schätzle P,Ludwig A,Tagaya M,Kunz B,Sonderegger P
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Western Blot
Wed Aug 15 00:00:00 EDT 2012
Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.
Biology open
Steuble M,Diep TM,Schätzle P,Ludwig A,Tagaya M,Kunz B,Sonderegger P
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Western Blot
Wed Aug 15 00:00:00 EDT 2012
Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport.
Biology open
Steuble M,Diep TM,Schätzle P,Ludwig A,Tagaya M,Kunz B,Sonderegger P
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Western Blot
Wed Aug 15 00:00:00 EDT 2012
Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology.
Journal of neuroinflammation
Ferretti MT,Allard S,Partridge V,Ducatenzeiler A,Cuello AC
PA1-757 was used in western blot to study the effect of minocycline on neuroinflammation and BACE-1 activity in a transgenic model of Alzheimer's disease
Mon Apr 02 00:00:00 EDT 2012
Involvement of receptor tyrosine kinase Tyro3 in amyloidogenic APP processing and β-amyloid deposition in Alzheimer's disease models.
PloS one
Zheng Y,Wang Q,Xiao B,Lu Q,Wang Y,Wang X
PA1-757 was used in western blot to study the role of receptor tyrosine kinase Tyro3 in APP processing and beta amyloid deposition
Thu Nov 08 00:00:00 EST 2012
BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.
The Journal of biological chemistry
Kang EL,Biscaro B,Piazza F,Tesco G
PA1-757 was used in Immunocytochemistry to assess the effects of the lack of ubiquitination at Lys-501 in Β-Site amyloid precursor protein-cleaving enzyme.
Fri Dec 14 00:00:00 EST 2012
Development of a specific ELISA to measure BACE1 levels in human tissues.
Journal of neuroscience methods
Gonzales A,Decourt B,Walker A,Condjella R,Nural H,Sabbagh MN
PA1-757 was used in Western Blotting to develop an immunoassay capable of measuring BACE1 levels in human brain and platelet lysates, as a potential marker of Alzheimer's disease.
Sun Oct 30 00:00:00 EDT 2011
The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.
Journal of neuroinflammation
Zhao J,O'Connor T,Vassar R
PA1-757 was used in western blot to investigate the involvement of activated astrocytes in beta-amyloid production in Alzheimer disease
Wed Nov 02 00:00:00 EDT 2011
The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis.
Journal of neuroinflammation
Zhao J,O'Connor T,Vassar R
PA1-757 was used in western blot to investigate the involvement of activated astrocytes in beta-amyloid production in Alzheimer disease
Wed Nov 02 00:00:00 EDT 2011
Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models.
PloS one
Zhao Y,Calon F,Julien C,Winkler JW,Petasis NA,Lukiw WJ,Bazan NG
PA1-757 was used in western blot to study the mechanism for the effect of docosahexaenoic acid-derived neuroprotectin D1 on neuronal survival
Wed Jan 05 00:00:00 EST 2011
Ubiquitin regulates GGA3-mediated degradation of BACE1.
The Journal of biological chemistry
Kang EL,Cameron AN,Piazza F,Walker KR,Tesco G
PA1-757 was used in immunoprecipitation to investigate the effect of ubiquitin during GGA3-mediated degradation of BACE1
Fri Jul 30 00:00:00 EDT 2010
Ubiquitin regulates GGA3-mediated degradation of BACE1.
The Journal of biological chemistry
Kang EL,Cameron AN,Piazza F,Walker KR,Tesco G
PA1-757 was used in immunoprecipitation to investigate the effect of ubiquitin during GGA3-mediated degradation of BACE1
Fri Jul 30 00:00:00 EDT 2010
Ubiquitin regulates GGA3-mediated degradation of BACE1.
The Journal of biological chemistry
Kang EL,Cameron AN,Piazza F,Walker KR,Tesco G
PA1-757 was used in immunoprecipitation to investigate the effect of ubiquitin during GGA3-mediated degradation of BACE1
Fri Jul 30 00:00:00 EDT 2010
Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.
Neurobiology of aging
Karuppagounder SS,Xu H,Shi Q,Chen LH,Pedrini S,Pechman D,Baker H,Beal MF,Gandy SE,Gibson GE
PA1-757 was used in western blot to investigate the effect of thiamine deficiency on Alzheimer's pathogenesis
Thu Oct 01 00:00:00 EDT 2009
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
The Journal of biological chemistry
Sarajärvi T,Haapasalo A,Viswanathan J,Mäkinen P,Laitinen M,Soininen H,Hiltunen M
PA1-757 was used in western blot to investigate how seladin-1 regulates BACE1 levels and activity during apoptosis
Fri Dec 04 00:00:00 EST 2009
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
The Journal of biological chemistry
Sarajärvi T,Haapasalo A,Viswanathan J,Mäkinen P,Laitinen M,Soininen H,Hiltunen M
PA1-757 was used in western blot to investigate how seladin-1 regulates BACE1 levels and activity during apoptosis
Fri Dec 04 00:00:00 EST 2009
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
The Journal of biological chemistry
Sarajärvi T,Haapasalo A,Viswanathan J,Mäkinen P,Laitinen M,Soininen H,Hiltunen M
PA1-757 was used in western blot to investigate how seladin-1 regulates BACE1 levels and activity during apoptosis
Fri Dec 04 00:00:00 EST 2009
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
Neuron
O'Connor T,Sadleir KR,Maus E,Velliquette RA,Zhao J,Cole SL,Eimer WA,Hitt B,Bembinster LA,Lammich S,Lichtenthaler SF,Hébert SS,De Strooper B,Haass C,Bennett DA,Vassar R
PA1-757 was used in immunoprecipitation to study the roles of the eIF2alpha phosphorylation in sporadic AD
Fri Dec 26 00:00:00 EST 2008
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
Neuron
O'Connor T,Sadleir KR,Maus E,Velliquette RA,Zhao J,Cole SL,Eimer WA,Hitt B,Bembinster LA,Lammich S,Lichtenthaler SF,Hébert SS,De Strooper B,Haass C,Bennett DA,Vassar R
PA1-757 was used in immunoprecipitation to study the roles of the eIF2alpha phosphorylation in sporadic AD
Fri Dec 26 00:00:00 EST 2008
Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao J,Fu Y,Yasvoina M,Shao P,Hitt B,O'Connor T,Logan S,Maus E,Citron M,Berry R,Binder L,Vassar R
PA1-757 was used in ELISA to study the expression of beta-site amyloid precursor protein cleaving enzyme 1 in neurons neighboring amyloid plaques.
Wed Apr 04 00:00:00 EDT 2007
Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Zhao J,Fu Y,Yasvoina M,Shao P,Hitt B,O'Connor T,Logan S,Maus E,Citron M,Berry R,Binder L,Vassar R
PA1-757 was used in ELISA to study the expression of beta-site amyloid precursor protein cleaving enzyme 1 in neurons neighboring amyloid plaques.
Wed Apr 04 00:00:00 EDT 2007
Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.
The European journal of neuroscience
Ohno M,Chang L,Tseng W,Oakley H,Citron M,Klein WL,Vassar R,Disterhoft JF
Published figure using BACE1 polyclonal antibody (Product # PA1-757) in Western Blot
Sun Jan 01 00:00:00 EST 2006
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
The Journal of biological chemistry
Hiltunen M,Lu A,Thomas AV,Romano DM,Kim M,Jones PB,Xie Z,Kounnas MZ,Wagner SL,Berezovska O,Hyman BT,Tesco G,Bertram L,Tanzi RE
PA1-757 was used in western blot to investigate the role of ubiquilin 1 during the amyloid precursor protein trafficking and Abeta secretion.
Fri Oct 27 00:00:00 EDT 2006
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
The Journal of biological chemistry
Hiltunen M,Lu A,Thomas AV,Romano DM,Kim M,Jones PB,Xie Z,Kounnas MZ,Wagner SL,Berezovska O,Hyman BT,Tesco G,Bertram L,Tanzi RE
PA1-757 was used in western blot to investigate the role of ubiquilin 1 during the amyloid precursor protein trafficking and Abeta secretion.
Fri Oct 27 00:00:00 EDT 2006
Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Velliquette RA,O'Connor T,Vassar R
PA1-757 was used in western blot to investigate the role of impaired energy production in the brain in the AD pathogenesis.
Wed Nov 23 00:00:00 EST 2005
Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.
The Journal of biological chemistry
Cole SL,Grudzien A,Manhart IO,Kelly BL,Oakley H,Vassar R
PA1-757 was used in western blot to demonstrate the effect of isoprenylation on intracellular amyloid beta-peptide level.
Fri May 13 00:00:00 EDT 2005
Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.
The Journal of biological chemistry
Cole SL,Grudzien A,Manhart IO,Kelly BL,Oakley H,Vassar R
PA1-757 was used in western blot to demonstrate the effect of isoprenylation on intracellular amyloid beta-peptide level.
Fri May 13 00:00:00 EDT 2005
BACE is degraded via the lysosomal pathway.
The Journal of biological chemistry
Koh YH,von Arnim CA,Hyman BT,Tanzi RE,Tesco G
PA1-757 was used in western blot to investigate BACE degradation via the lysosomal pathway.
Fri Sep 16 00:00:00 EDT 2005
The metabolism of beta-amyloid converting enzyme and beta-amyloid precursor protein processing.
Biochemical and biophysical research communications
Benjannet S,Cromlish JA,Diallo K,Chrétien M,Seidah NG
PA1-757 was used in immunoprecipitation to investigate BACE metabolism and its influence on beta-amyloid production
Fri Dec 03 00:00:00 EST 2004
Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.
The Journal of biological chemistry
Pitsi D,Octave JN
PA1-757 was used in western blot to demonstrate the effect of presenilin 1 on Abeta production .
Fri Jun 11 00:00:00 EDT 2004
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Science (New York, N.Y.)
Vassar R,Bennett BD,Babu-Khan S,Kahn S,Mendiaz EA,Denis P,Teplow DB,Ross S,Amarante P,Loeloff R,Luo Y,Fisher S,Fuller J,Edenson S,Lile J,Jarosinski MA,Biere AL,Curran E,Burgess T,Louis JC,Collins F,Treanor J,Rogers G,Citron M
PA1-757 was used in immunoprecipitation to investigate beta-secretase cleavage of APP protein mediated by BACE
Fri Oct 22 00:00:00 EDT 1999
