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Product Details
PA1-9014
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the N terminus amino acids ASGQGPGPPRQE.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2290037
Product Specific Information
This antibody is predicted to react with mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.
Target Information
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis regulator BAK; Bcl-2 homologous antagonist/killer; Bcl-2-like protein 7; BCL2-antagonist/killer 1; Bcl2-L-7; BCL2-like 7 protein; BCL2-like 7protein; MGC117255; MGC3887; pro-apoptotic protein BAK
Gene Aliases: BAK; BAK-LIKE; BAK1; BCL2L7; CDN1
UniProt ID: (Human) Q16611
Entrez Gene ID: (Human) 578
B cell homeostasis
B cell apoptotic process
release of cytochrome c from mitochondria
blood vessel remodeling
myeloid cell homeostasis
B cell negative selection
activation of signaling protein activity involved in unfolded protein response
brain development
aging
mitochondrial fusion
cell proliferation
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
response to fungus
response to mycotoxin
response to UV-C
establishment or maintenance of transmembrane electrochemical gradient
response to gamma radiation
positive regulation of calcium ion transport into cytosol
negative regulation of gene expression
response to organic cyclic compound
cytolysis
endocrine pancreas development
organ regeneration
endoplasmic reticulum calcium ion homeostasis
negative regulation of endoplasmic reticulum calcium ion concentration
negative regulation of peptidyl-serine phosphorylation
cellular response to UV
limb morphogenesis
response to drug
response to hydrogen peroxide
positive regulation of apoptotic process
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
fibroblast apoptotic process
response to ethanol
positive regulation of proteolysis
regulation of mitochondrial membrane permeability
post-embryonic camera-type eye morphogenesis
regulation of cell cycle
regulation of mitochondrial membrane potential
vagina development
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
thymocyte apoptotic process
cellular response to mechanical stimulus
positive regulation of release of cytochrome c from mitochondria
apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
activation of cysteine-type endopeptidase activity
positive regulation of endoplasmic reticulum unfolded protein response
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
apoptotic process involved in patterning of blood vessels
positive regulation of IRE1-mediated unfolded protein response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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