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BATF Antibody (PA5-104545) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded BATF in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with BATF polyclonal antibody (Product # PA5-104545) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-104545
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BATF(Accession Q16520), corresponding to amino acid residues M1-K50.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2853845
Product Specific Information
Antibody detects endogenous levels of total BATF.
Target Information
BATF is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events and blocks cellular transformation by Ras and Fos. BATF also is required for the differentiation of IL-17-producing T helper (TH17) cells, a CD4+ subset of T cells that coordinates the inflammatory response in host defense. In both T cells and B cells, BATF is required for the appropriate regulation of the class-switch recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activating transcription factor B; B-ATF; B-cell activating transcription factor; B-cell-activating transcription factor; basic leucine zipper transcription factor, ATF-like; basic leucine zipper transcription factor-like; Basic leucine zipper transcriptional factor ATF-like; SF-HT-activated gene 2 protein; SFA-2
Gene Aliases: B-ATF; BATF; BATF1; SFA-2; SFA2
UniProt ID: (Human) Q16520, (Mouse) O35284
Entrez Gene ID: (Human) 10538, (Mouse) 53314
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
DNA binding
basic leucine zipper transcription factor
cytokine production
lymphoid progenitor cell differentiation
transcription from RNA polymerase II promoter
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator
defense response to protozoan
myeloid dendritic cell differentiation
T-helper 2 cell differentiation
isotype switching
positive regulation of transcription from RNA polymerase II promoter
hematopoietic stem cell differentiation
T-helper 17 cell differentiation
T-helper 17 cell lineage commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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