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Product Details
602-950
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide derived from N-terminus of human BCL-W protein
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with proprietary stabilizer
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
Product Specific Information
Positive control: Breast carcinoma
Cellular location: Mitochondria outer membrane, Nucleus membrane.
Target Information
Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: anti-apoptotic member of Bcl-2 family; BCL2L2; Apoptosis regulator Bcl-W; Bcl-2-like protein 2; Bcl2-L-2; BCL2-like 2 protein; Bcl2-like protein 2; c98; protein phosphatase 1, regulatory subunit 51; v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65
Gene Aliases: AW048834; BCL-W; BCL-WEL; BCL-WS; BCL2-L-2; BCL2L2; BCLW; c98; Gtrgal2; Gtrosa41; KIAA0271; PPP1R51; RELA
UniProt ID: (Human) Q92843, (Bovine) Q1RMX3, (Dog) Q45T69, (Mouse) P70345
Entrez Gene ID: (Human) 599, (Bovine) 767601, (Dog) 490611, (Mouse) 12050, (Rat) 60434
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
negative regulation of apoptotic process
Sertoli cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway
apoptotic process
regulation of apoptotic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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