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Product Details
H00000602-D01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCL3 (NP_005169.1, 1 a.a. approximately 446 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDEGPVDLRT RPKAAGLPGA ALPLRKRPLR APSPEPAAPR GAAGLVVPLD PLRGGCDLPA VPGPPHGLAR PEALYYPGAL LPLYPTRAMG SPFPLVNLPT PLYPMMCPME HPLSADIAMA TRADEDGDTP LHIAVVQGNL PAVHRLVNLF QQGGRELDIY NNLRQTPLHL AVITTLPSVV RLLVTAGASP MALDRHGQTA AHLACEHRSP TCLRALLDSA APGTLDLEAR NYDGLTALHV AVNTECQETV QLLLERGADI DAVDIKSGRS PLIHAVENNS LSMVQLLLQH GANVNAQMYS GSSALHSASG RGLLPLVRTL VRSGADSSLK NCHNDTPLMV ARSRRVIDIL RGKATRPAST SQPDPSPDRS ANTSPESSSR LSSNGLLSAS PSSSPSQSPP RDPPGFPMAP PNFFLPSPSP PAFLPFAGVL RGPGRPVPPS PAPGGS
Target Information
B cell Lymphoma 3 is a member of the IkB subfamily of inhibitors. This subfamily is part of the NF-kB transcription factor protein family and it is suggested that a balance in the concentration of various NF-kB family members regulates apoptosis and survival of activated T cells. Bcl-3 has been shown to have versatile functions such as cytoplasmic activation of p50 homodimers, translocation to the nucleus, and modulation of the transcriptional machinery in the nucleus. Bcl-3 activity often relies on several nuclear interacting proteins such as Tip60, Jab1, Bard1, and Pirin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell leukemia/lymphoma 3; B-cell lymphoma 3 protein; B-cell lymphoma 3-encoded protein; BCL-3; Bcl-3 protein; chronic lymphatic leukemia protein; Proto-oncogene BCL3
Gene Aliases: BCL3; BCL4; D19S37
UniProt ID: (Human) P20749
Entrez Gene ID: (Human) 602
protein import into nucleus, translocation
follicular dendritic cell differentiation
marginal zone B cell differentiation
humoral immune response mediated by circulating immunoglobulin
germinal center formation
transcription, DNA-templated
cellular response to DNA damage stimulus
I-kappaB kinase/NF-kappaB signaling
response to virus
response to UV-C
antimicrobial humoral response
extracellular matrix organization
DNA damage response, signal transduction by p53 class mediator
positive regulation of interferon-gamma production
T-helper 1 type immune response
regulation of NF-kappaB import into nucleus
negative regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
defense response to protozoan
regulation of apoptotic process
negative regulation of apoptotic process
T-helper 2 cell differentiation
positive regulation of interleukin-10 biosynthetic process
negative regulation of interleukin-8 biosynthetic process
positive regulation of translation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
regulation of DNA binding
maintenance of protein location in nucleus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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