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BCL6 Antibody (CL647-66340) in Flow
1x10^6 Ramos cells were intracellularly stained with 0.8 µg CoraLite® Plus 647-conjugated BCL6 Monoclonal antibody (CL647-66340, Clone:1E6B1)(red), or 0.8 µg CoraLite® Plus 647 Mouse IgG1 Isotype Control (MOPC-21) (CL647-65124, Clone: MOPC-21) (blue). Cells were fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011).
Product Details
CL647-66340
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1E6B1
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
654/674 nm
Form
Liquid
Purification
Protein G
Storage buffer
PBS with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: SLYSGLSTPP ASYSMYSHLP VSSLLFSDEE FRDVRMPVAN PFPKERALPC DSARPVPGEY SRPTLEVSPN VCHSNIYSPK ETIPEEARSD MHYSVAEGLK PAAPSARNAP YFPCDKASKE EERPSSEDEI ALHFEPPNAP LNRKGLVSPQ SPQKSDCQPN SPTESCSSKN ACILQASGSP PAKSPTDPKA CNWKKYKFIV LNSLNQNAKP EGPEQAELGR LSPRAYTAPP ACQPPMEPEN LDLQSPTKLS ASGEDSTIPQ ASRLNNIVNR SMTGSPRSSS ESHSPLYMHP PKCTSCGSQS PQHAEMCLHT AGPTFPEEMG ETQSEYSDSS CENGAFFCNE CDCRFSEEAS
Target Information
Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S
Gene Aliases: BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51
UniProt ID: (Human) P41182
Entrez Gene ID: (Human) 604
RNA polymerase II regulatory region sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
sequence-specific DNA binding
metal ion binding
C2H2 zinc finger transcription factor
protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
negative regulation of cell-matrix adhesion
germinal center formation
regulation of germinal center formation
negative regulation of B cell apoptotic process
transcription, DNA-templated
inflammatory response
cellular response to DNA damage stimulus
Rho protein signal transduction
spermatogenesis
negative regulation of cell proliferation
actin cytoskeleton organization
myeloid cell differentiation
B cell differentiation
negative regulation of cell growth
positive regulation of B cell proliferation
positive regulation of histone deacetylation
negative regulation of mast cell cytokine production
negative regulation of Rho protein signal transduction
type 2 immune response
regulation of cell proliferation
regulation of apoptotic process
positive regulation of apoptotic process
regulation of GTPase activity
regulation of memory T cell differentiation
negative regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
negative regulation of isotype switching to IgE isotypes
erythrocyte development
regulation of inflammatory response
regulation of neurogenesis
regulation of immune response
positive regulation of cellular component movement
negative regulation of cellular senescence
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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