Invitrogen

BCL6 Monoclonal Antibody (BL6.02 (PG-B6p))

BCL6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 3

BCL6 Antibody (MA5-11493) in IHC (P)

Formalin-fixed, paraffin-embedded human tonsil stained with Bcl-6 antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of lymphocytes in the germinal center.

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Product Details

MA5-11493

Applications

Tested Dilution

Publications

Western Blot (WB)

1:10-1:100

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Bovine, Human, Mouse, Sheep, Pig, Rabbit, Rat

Published species

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

BL6.02 (PG-B6p)

Immunogen

Recombinant protein corresponding to amino acids 3-484 of the human Bcl-6 protein

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

tissue culture supernatant

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Wet ice

RRID

AB_10982856

Product Specific Information

MA5-11493 targets BCL-6 in IHC (P) and Western blot applications and shows reactivity with Bovine, Human, Ovine, Porcine, Rabbit, Mouse and Rat samples.

The MA5-11493 immunogen is recombinant protein corresponding to amino acids 3-484 of the human Bcl-6 protein.

Target Information

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

αvβ6 Integrin Promotes Castrate-Resistant Prostate Cancer through JNK1-Mediated Activation of Androgen Receptor.

Cancer research

Lu H,Wang T,Li J,Fedele C,Liu Q,Zhang J,Jiang Z,Jain D,Iozzo RV,Violette SM,Weinreb PH,Davis RJ,Gioeli D,FitzGerald TJ,Altieri DC,Languino LR

MA511493 was used in immunocytochemistry to describe the crosstalk of alphavbeta6-integrin and androgen receptor in prostate cancer.

Thu Sep 01 00:00:00 EDT 2016

The expression of IgM is helpful in the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma.

Leukemia research

Demirkesen C,Tüzüner N,Esen T,Lebe B,Ozkal S

MA5-11493 was used in immunohistochemistry to investigate the effect of IgM expressoin on the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma

Thu Sep 01 00:00:00 EDT 2011

E2A-positive gastric MALT lymphoma has weaker plasmacytoid infiltrates and stronger expression of the memory B-cell-associated miR-223: possible correlation with stage and treatment response.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Liu TY,Chen SU,Kuo SH,Cheng AL,Lin CW

MA5-11493 was used in immunohistochemistry to investigate the correlation between miR-223 expression and gastric MALT lymphoma

Mon Nov 01 00:00:00 EDT 2010

B-cell lymphofollicular infiltrates in mycosis fungoides.

Tumori

Ferrara G,Chiarelli C,Simonetti S

MA5-11493 was used in immunohistochemistry to investigate specific histopathological features of B-cell lymphofollicular infiltrates in mycosis fungoides

Thu Sep 30 00:00:00 EDT 2010

Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity.

Blood

Smit LA,Hallaert DY,Spijker R,de Goeij B,Jaspers A,Kater AP,van Oers MH,van Noesel CJ,Eldering E

MA5-11493 was used in immunohistochemistry to investigate the role of Noxa expression in the pathogenesis of chronic lymphocytic leukemia

Thu Feb 15 00:00:00 EST 2007

Enhancement of clonogenicity of human multiple myeloma by dendritic cells.

The Journal of experimental medicine

Kukreja A,Hutchinson A,Dhodapkar K,Mazumder A,Vesole D,Angitapalli R,Jagannath S,Dhodapkar MV

MA5-11493 was used in immunocytochemistry to investigate the interaction between tumors and dendritic cells

Mon Aug 07 00:00:00 EDT 2006

Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease.

World journal of gastroenterology

Vaiphei K,Kumari N,Sinha SK,Dutta U,Nagi B,Joshi K,Singh K

MA5-11493 was used in immunohistochemistry to examine the diagnostic and prognostic significance of multiple proteins in immunoproliferative small intestinal disease

Wed Jun 14 00:00:00 EDT 2006

Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma.

Blood

Wlodarska I,Nooyen P,Maes B,Martin-Subero JI,Siebert R,Pauwels P,De Wolf-Peeters C,Hagemeijer A

MA5-11493 was used in immunohistochemistry to investigate the occurrence of BCL6 mutation in different types of Hodgkin lymphoma

Wed Jan 15 00:00:00 EST 2003

Epstein-Barr virus-infected B cells expanding in germinal centers of infectious mononucleosis patients do not participate in the germinal center reaction.

Proceedings of the National Academy of Sciences of the United States of America

Kurth J,Hansmann ML,Rajewsky K,Küppers R

MA5-11493 was used in immunohistochemistry to study the changes in germinal center after the Epstein-Barr virus infection

Tue Apr 15 00:00:00 EDT 2003

Bioinformatics

Protein Aliases: B cell CLL/lymphoma 6; B-cell CLL/lymphoma 6 (zinc finger protein 51); B-cell leukemia/lymphoma 5; B-cell leukemia/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein homolog; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S

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Gene Aliases: Bcl-6; BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51

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UniProt ID: (Human) P41182, (Mouse) P41183

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Entrez Gene ID: (Pig) 100156549, (Bovine) 539020, (Sheep) 101110557, (Human) 604, (Rabbit) 100353941, (Rat) 303836, (Mouse) 12053

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Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding chromatin DNA binding sequence-specific DNA binding metal ion binding molecular_function DNA binding nucleic acid binding C2H2 zinc finger transcription factor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BCL6 Monoclonal Antibody (BL6.02 (PG-B6p))

BCL6 Antibody (MA5-11493) in IHC (P)

Product Details

MA5-11493

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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