Proteintech

BID Polyclonal Antibody

BID Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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BID Antibody (10988-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 10988-1-AP (BID antibody) at dilution of 1:100 (under 10x lens).

BID Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10988-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 46 publications 46 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BID Fusion Protein Ag1445 (1-195 aa encoded by BC009197)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MDCEVNNGS SLRDECITNL LVFGFLQSCS DNSFRRELDA LGHELPVLAP QWEGYDELQT DGNRSSHSRL GRIEADSESQ EDIIRNIARH LAQVGDSMDR SIPPGLVNGL ALQLRNTSRS EEDRNRDLAT ALEQLLQAYP RDMEKEKTML VLALLLAKKV ASHTPSLLRD VFHTTVNFIN QNLRTYVRSL ARNGMD (1-195 aa encoded by B C009197)

Target Information

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: apoptic d; apoptic death agonist; BH3-interacting domain death agonist; BID; BID isoform ES(1b); BID isoform L(2); BID isoform Si6; desmocollin type 4; HGNC:1050; Human BID coding sequence; MGC15319; MGC42355; OTTHUMP00000196197; p22 BID

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Gene Aliases: BID; FP497

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UniProt ID: (Human) P55957

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Entrez Gene ID: (Human) 637

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Function(s)

death receptor binding protein binding ubiquitin protein ligase binding

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BID Polyclonal Antibody

BID Antibody (10988-1-AP) in IHC (P)

Product Details

10988-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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