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Product Details
MA5-30112
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rhesus monkey,
Rat
Host/Isotype
Mouse
Class
Monoclonal
Type
Antibody
Clone
23
Immunogen
Recombinant Human BMP-2 Protein (Gln283-Arg396)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2785889
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human BMP-2.
Target Information
Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP; BMP-2; BMP-2A; BMPR-II; BMPRII; Bone morphogenetic protein; Bone morphogenetic protein 2; Bone morphogenetic protein 2A; H-BMP-2
Gene Aliases: AI467020; BDA2; Bmp-2; BMP2; BMP2A; EGK_02657
UniProt ID: (Human) P12643, (Mouse) P21274, (Rat) P49001
Entrez Gene ID: (Dog) 477162, (Rhesus monkey) 718330, (Human) 650, (Mouse) 12156, (Rat) 29373
retinol dehydrogenase activity
receptor binding
cytokine activity
transforming growth factor beta receptor binding
protein binding
growth factor activity
phosphatase activator activity
co-receptor binding
SMAD binding
protein heterodimerization activity
BMP receptor binding
protein domain specific binding
protein homodimerization activity
growth factor
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
skeletal system development
osteoblast differentiation
branching involved in ureteric bud morphogenesis
response to hypoxia
in utero embryonic development
epithelial to mesenchymal transition
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
chondrocyte differentiation
BMP signaling pathway involved in heart induction
atrioventricular valve morphogenesis
endocardial cushion morphogenesis
negative regulation of Wnt signaling pathway involved in heart development
proteoglycan metabolic process
regulation of transcription, DNA-templated
protein phosphorylation
inflammatory response
Notch signaling pathway
cell-cell signaling
heart development
negative regulation of cell proliferation
embryo development
organ morphogenesis
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of steroid biosynthetic process
positive regulation of phosphatase activity
telencephalon development
telencephalon regionalization
positive regulation of Wnt signaling pathway
bone mineralization
positive regulation of cell migration
positive regulation of bone mineralization
BMP signaling pathway
protein destabilization
positive regulation of protein binding
negative regulation of aldosterone biosynthetic process
positive regulation of osteoblast proliferation
cardiocyte differentiation
embryonic heart tube anterior/posterior pattern specification
bone mineralization involved in bone maturation
growth
odontogenesis of dentin-containing tooth
positive regulation of odontogenesis
regulation of odontogenesis of dentin-containing tooth
positive regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of insulin-like growth factor receptor signaling pathway
cell fate commitment
positive regulation of fat cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of astrocyte differentiation
mesenchymal cell differentiation
inner ear development
negative regulation of calcium-independent cell-cell adhesion
cardiac muscle cell differentiation
cardiac muscle tissue morphogenesis
oxidation-reduction process
pericardium development
corticotropin hormone secreting cell differentiation
thyroid-stimulating hormone-secreting cell differentiation
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
mesenchyme development
positive regulation of Wnt signaling pathway by BMP signaling pathway
positive regulation of cartilage development
positive regulation of ERK1 and ERK2 cascade
cellular response to organic cyclic compound
cellular response to BMP stimulus
mesenchymal cell proliferation involved in ureteric bud development
negative regulation of canonical Wnt signaling pathway
positive regulation of p38MAPK cascade
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
negative regulation of cortisol biosynthetic process
negative regulation of cardiac muscle cell differentiation
ossification
transforming growth factor beta receptor signaling pathway
multicellular organism development
negative regulation of gene expression
cell differentiation
regulation of apoptotic process
regulation of MAPK cascade
positive regulation of cell differentiation
cell development
positive regulation of neurogenesis
cartilage development
cellular response to growth factor stimulus
response to mechanical stimulus
response to retinoic acid
ovulation cycle
cellular response to mechanical stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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