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BMP-6 Antibody (PA5-47829) in IHC (F)
Immunohistochemical analysis of BMP-6 in immersion fixed frozen sections of mouse embryo (15 d.p.c.). Samples were incubated in BMP-6 polyclonal antibody (Product # PA5-47829) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to skeletal muscle cells.
Product Details
PA5-47829
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CHO-derived recombinant mouse BMP-6 Ser372-His510
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609225
Product Specific Information
This antibody detects recombinant human and mouse BMP-6 in direct ELISAs and mouse BMP-6 in Western blots. In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) BMP-5 and rmBMP-7 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
Target Information
BMP6 is a member of bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP 6; BMP-6; Bone morphogenetic protein; Bone morphogenetic protein 6; VG-1-related protein; VGR-1
Gene Aliases: Bmp-6; Bmp6; D13Wsu115e; Vgr1
UniProt ID: (Mouse) P20722
Entrez Gene ID: (Mouse) 12161
ossification
osteoblast differentiation
eye development
kidney development
positive regulation of endothelial cell proliferation
endochondral ossification
type B pancreatic cell development
cellular iron ion homeostasis
immune response
multicellular organism development
positive regulation of pathway-restricted SMAD protein phosphorylation
cell differentiation
positive regulation of bone mineralization
BMP signaling pathway
male genitalia development
positive regulation of chondrocyte differentiation
positive regulation of aldosterone biosynthetic process
growth
regulation of apoptotic process
regulation of MAPK cascade
positive regulation of endothelial cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
cell development
positive regulation of epithelial cell proliferation
cartilage development
SMAD protein signal transduction
positive regulation of aldosterone secretion
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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