Invitrogen

BMP-6 Polyclonal Antibody

View all (19) BMP6 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-99409

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human BMP6(Accession P22004), corresponding to amino acid residues A132-L182.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2818342

Product Specific Information

Antibody detects endogenous levels of total BMP6.

Target Information

BMP6 is a member of bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BMP; BMP 6; BMP-6; Bone morphogenetic protein; Bone morphogenetic protein 6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; VGR-1

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Gene Aliases: BMP6; VGR; VGR1

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UniProt ID: (Human) P22004

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Entrez Gene ID: (Human) 654

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Function(s)
cytokine activity transforming growth factor beta receptor binding growth factor activity protein heterodimerization activity BMP receptor binding growth factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast differentiation eye development kidney development positive regulation of endothelial cell proliferation endochondral ossification type B pancreatic cell development cellular iron ion homeostasis inflammatory response immune response positive regulation of pathway-restricted SMAD protein phosphorylation response to activity positive regulation of bone mineralization BMP signaling pathway male genitalia development positive regulation of lipopolysaccharide-mediated signaling pathway response to magnesium ion positive regulation of chondrocyte differentiation positive regulation of aldosterone biosynthetic process response to retinoic acid growth regulation of apoptotic process regulation of MAPK cascade positive regulation of endothelial cell differentiation positive regulation of neuron differentiation positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of epithelial cell proliferation positive regulation of protein secretion cartilage development response to glucocorticoid positive regulation of SMAD protein import into nucleus SMAD protein signal transduction multicellular organismal iron ion homeostasis cellular response to mechanical stimulus cellular response to iron ion cellular response to BMP stimulus positive regulation of DNA-dependent DNA replication positive regulation of aldosterone secretion
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