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Product Details
MA5-30113
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
02
Immunogen
Recombinant Human BMP-7 protein
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2785890
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human BMP-7.
Target Information
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP-7; Bone morphogenetic protein; Bone morphogenetic protein 7; OP-1; Osteogenic protein 1; RP11-560A15.5
Gene Aliases: BMP7; OP-1; OP1
UniProt ID: (Human) P18075
Entrez Gene ID: (Human) 655
skeletal system development
ossification
metanephros development
ureteric bud development
mesoderm formation
mesonephros development
epithelial to mesenchymal transition
axon guidance
embryonic pattern specification
negative regulation of striated muscle cell apoptotic process
positive regulation of peptidyl-threonine phosphorylation
positive regulation of pathway-restricted SMAD protein phosphorylation
dendrite development
embryonic limb morphogenesis
positive regulation of bone mineralization
BMP signaling pathway
epithelial cell differentiation
negative regulation of NF-kappaB transcription factor activity
response to estradiol
response to vitamin D
positive regulation of heterotypic cell-cell adhesion
protein localization to nucleus
growth
negative regulation of phosphorylation
negative regulation of NF-kappaB import into nucleus
odontogenesis of dentin-containing tooth
regulation of apoptotic process
positive regulation of apoptotic process
steroid hormone mediated signaling pathway
negative regulation of MAP kinase activity
response to peptide hormone
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
negative regulation of Notch signaling pathway
negative regulation of cell cycle
negative regulation of mitotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
embryonic camera-type eye morphogenesis
branching morphogenesis of an epithelial tube
mesenchymal cell differentiation
neuron projection morphogenesis
cartilage development
embryonic skeletal joint morphogenesis
regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
branching involved in salivary gland morphogenesis
mesenchyme development
negative regulation of cell death
negative regulation of prostatic bud formation
regulation of branching involved in prostate gland morphogenesis
monocyte aggregation
cellular response to hypoxia
cellular response to BMP stimulus
negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis
negative regulation of glomerular mesangial cell proliferation
metanephric mesenchyme morphogenesis
nephrogenic mesenchyme morphogenesis
metanephric mesenchymal cell proliferation involved in metanephros development
positive regulation of dendrite development
positive regulation of hyaluranon cable assembly
regulation of removal of superoxide radicals
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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