Proteintech

BMP2 Monoclonal Antibody (1C5C2)

BMP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

BMP2 Antibody (66383-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human small intestine tissue slide using 66383-1-IG ( BMP2 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

66383-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 25 publications 25 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Not applicable (N/A)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Pig

Published species

Not Applicable

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

1C5C2

Immunogen

BMP2 Fusion Protein Ag13501 (1-396 aa encoded by BC069214)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MVAGTRCLL ALLLPQVLLG GAAGLVPELG RRKFAAASSG RPSSQPSDEV LSEFELRLLS MFGLKQRPTP SRDAVVPPYM LDLYRRHSGQ PGSPAPDHRL ERAASRANTV RSFHHEESLE ELPETSGKTT RRFFFNLSSI PTEEFITSAE LQVFREQMQD ALGNNSSFHH RINIYEIIKP ATANSKFPVT SLLDTRLVNQ NASRWESFDV TPAVMRWTAQ GHANHGFVVE VAHLEEKQGV SKRHVRISRS LHQDEHSWSQ IRPLLVTFGH DGKGHPLHKR EKRQAKHKQR KRLKSSCKRH PLYVDFSDVG WNDWIVAPPG YHAFYCHGEC PFPLADHLNS TNHAIVQTLV NSVNSKIPKA CCVPTELSAI SMLYLDENEK VVLKNYQDMV VEGCGCR (1-396 aa encoded by BC069214)

Target Information

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

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Thu Feb 02 00:00:00 EST 2023

Resveratrol induces proliferation and differentiation of mouse pre-osteoblast MC3T3-E1 by promoting autophagy.

BMC complementary medicine and therapies

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Fri Apr 14 00:00:00 EDT 2023

Continuously released Zn²⁺ in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties.

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Li C,Sun F,Tian J,Li J,Sun H,Zhang Y,Guo S,Lin Y,Sun X,Zhao Y

Thu Jun 01 00:00:00 EDT 2023

Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study.

Phytotherapy research : PTR

Li H,Wang C,Jin Y,Cai Y,Yao J,Meng Q,Wu J,Wang H,Sun H,Liu M

Sun Jan 01 00:00:00 EST 2023

BMSC-derived extracellular vesicles promoted osteogenesis via Axin2 inhibition by delivering MiR-16-5p.

International immunopharmacology

Duan J,Li H,Wang C,Yao J,Jin Y,Zhao J,Zhang Y,Liu M,Sun H

Sat Jul 01 00:00:00 EDT 2023

Saturated fatty acid promotes calcification via suppressing SIRT6 expression in vascular smooth muscle cells.

Journal of hypertension

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Wed Mar 01 00:00:00 EST 2023

KLF9 Promotes Osteogenic Differentiation of Dental Stem Cells by Negatively Regulating Notch1 Mediated Signaling Pathway.

Frontiers in bioscience (Landmark edition)

Zhao X,Mai Z,Lu Y,Cui L,Yu J

Sat May 06 00:00:00 EDT 2023

XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells.

Tissue & cell

Cui Z,Qin R,Feng J,Liu Y,Zhou X,Qin X,Li Y,Zhang Z,He X

Tue Aug 01 00:00:00 EDT 2023

Transcriptome study digs out BMP2 involved in adipogenesis in sheep tails.

BMC genomics

Jin M,Fei X,Li T,Lu Z,Chu M,Di R,He X,Wang X,Wei C

Tue Jun 21 00:00:00 EDT 2022

Identification of Polysaccharides From Dipsacus asperoides and Their Effects on Osteoblast Proliferation and Differentiation in a High-Glucose Environment.

Frontiers in pharmacology

Xu D,Liu J,Zheng W,Gao Q,Gao Y,Leng X

Wed Apr 13 00:00:00 EDT 2022

Exosomes Derived from SW480-Resistant Colon Cancer Cells Are Promote Angiogenesis via BMP-2/Smad5 Signaling Pathway.

Applied bionics and biomechanics

Yang S,Yao L,Wang X,Sun H,Du C,Song C,Fu J,Wu Y,Huang H,Wang C,Wang Y,Xie Y

Fri Aug 25 00:00:00 EDT 2023

Effect of LncRNA-MALAT1 on mineralization of dental pulp cells in a high-glucose microenvironment.

Frontiers in cell and developmental biology

Li X,Xu W,Lin X,Wu J,Wu B

Tue Aug 30 00:00:00 EDT 2022

Increased Methyl-CpG-Binding Domain Protein 2 Promotes Cigarette Smoke-Induced Pulmonary Hypertension.

Frontiers in oncology

Wu J,Huang Q,Li Q,Gu Y,Zhan Y,Wang T,Chen J,Zeng Z,Lv Y,Zhao J,Xia J,Xie J

Sat Jul 16 00:00:00 EDT 2022

The effect and mechanism of gene Fam20a on the development and function of salivary glands in mice.

Archives of oral biology

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Sun May 01 00:00:00 EDT 2022

STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis.

Journal of cellular and molecular medicine

Xu Y,Bao X,Chen X,Wu P,Chen S,Zhang B,Ma J,Xu G,Ma D

Tue Mar 01 00:00:00 EST 2022

LIM Mineralization Protein-1 Enhances the Committed Differentiation of Dental Pulp Stem Cells through the ERK1/2 and p38 MAPK Pathways and BMP Signaling.

International journal of medical sciences

Mu R,Chen B,Bi B,Yu H,Liu J,Li J,He M,Rong L,Liu B,Liu K,Zhu L,Shi X,Shuai Y,Jin L

Mon Aug 08 00:00:00 EDT 2022

Mechanism of Endoplasmic Reticulum Stress Pathway in the Osteogenic Phenotypic Transformation of Aortic Valve Interstitial Cells.

Frontiers in endocrinology

Tao Y,Geng Y,Dang W,Xu X,Zhao H,Zou L,Li Y

Fri Apr 01 00:00:00 EDT 2022

Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.

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Tan Z,Si Y,Yu Y,Ding J,Huang L,Xu Y,Zhang H,Lu Y,Wang C,Yu B,Yuan L

Sat Jul 16 00:00:00 EDT 2022

Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.

Frontiers in pharmacology

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Sat Jul 16 00:00:00 EDT 2022

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Stem cell research & therapy

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Sat Aug 13 00:00:00 EDT 2022

Enterobacter cloacae: a villain in CaOx stone disease?

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Fri Apr 01 00:00:00 EDT 2022

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Halide-containing bioactive glasses enhance osteogenesis in vitro and in vivo.

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Chen X,Liu Y,Zhao Y,Ouyang Z,Zhou H,Li L,Li L,Li F,Xie X,Hill RG,Wang S,Chen X

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Oar-miR-432 Regulates Fat Differentiation and Promotes the Expression of BMP2 in Ovine Preadipocytes.

Frontiers in genetics

Jin M,Fei X,Li T,Lu Z,Chu M,Di R,He X,Wang X,Wang Y,Yuan Z,Quan K,Wang H,Wei C

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Linalool inhibits the angiogenic activity of endothelial cells by downregulating intracellular ATP levels and activating TRPM8.

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Becker V,Hui X,Nalbach L,Ampofo E,Lipp P,Menger MD,Laschke MW,Gu Y

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Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way.

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ACS applied materials & interfaces

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Endocrinology

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MnTBAP inhibits bone loss in ovariectomized rats by reducing mitochondrial oxidative stress in osteoblasts.

Journal of bone and mineral metabolism

Cao X,Luo D,Li T,Huang Z,Zou W,Wang L,Lian K,Lin D

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MnTBAP inhibits bone loss in ovariectomized rats by reducing mitochondrial oxidative stress in osteoblasts.

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Bioinformatics

Protein Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP; BMP-2; BMP-2A; BMPR-II; BMPRII; Bone morphogenetic protein; Bone morphogenetic protein 2; Bone morphogenetic protein 2A; H-BMP-2; morphogen

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Gene Aliases: BDA2; BMP2; BMP2A

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UniProt ID: (Human) P12643

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Entrez Gene ID: (Human) 650, (Pig) 100157103

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Function(s)

retinol dehydrogenase activity receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity phosphatase activator activity co-receptor binding SMAD binding protein heterodimerization activity BMP receptor binding growth factor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BMP2 Monoclonal Antibody (1C5C2)

BMP2 Antibody (66383-1-IG) in IHC (P)

Product Details

66383-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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