BMP4 Monoclonal Antibody (UMAB42), UltraMAB™

cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity heparin binding co-receptor binding chemoattractant activity protein homodimerization activity BMP receptor binding growth factor

negative regulation of transcription from RNA polymerase II promoter activation of MAPKK activity ovarian follicle development osteoblast differentiation ureteric bud development branching involved in ureteric bud morphogenesis kidney development mesonephros development neural tube closure positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation endochondral ossification blood vessel endothelial cell proliferation involved in sprouting angiogenesis chondrocyte differentiation hematopoietic progenitor cell differentiation lymphoid progenitor cell differentiation renal system process BMP signaling pathway involved in heart induction secondary heart field specification outflow tract septum morphogenesis membranous septum morphogenesis muscular septum morphogenesis aortic valve morphogenesis pulmonary valve morphogenesis endocardial cushion development epithelial to mesenchymal transition involved in endocardial cushion formation cardiac right ventricle morphogenesis apoptotic process involved in endocardial cushion morphogenesis cardiac septum development type B pancreatic cell development mesenchymal to epithelial transition involved in metanephros morphogenesis common-partner SMAD protein phosphorylation smoothened signaling pathway germ cell development mesodermal cell fate determination negative regulation of cell proliferation post-embryonic development anterior/posterior axis specification specification of organ position regulation of cell fate commitment positive regulation of calcium ion transport into cytosol positive regulation of endothelial cell migration positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of cell death positive regulation of neuron projection development telencephalon development dorsal/ventral neural tube patterning telencephalon regionalization pituitary gland development erythrocyte differentiation monocyte differentiation macrophage differentiation positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway positive regulation of protein binding negative regulation of chondrocyte differentiation response to estradiol response to retinoic acid positive regulation of collagen biosynthetic process negative regulation of T cell differentiation in thymus negative regulation of immature T cell proliferation in thymus response to testosterone protein localization to nucleus cellular response to oxidative stress embryonic hindlimb morphogenesis tendon cell differentiation deltoid tuberosity development wound healing regulation of protein import into nucleus negative regulation of phosphorylation odontogenesis of dentin-containing tooth odontogenesis regulation of odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of apoptotic process negative regulation of apoptotic process steroid hormone mediated signaling pathway negative regulation of MAP kinase activity tongue morphogenesis positive regulation of endothelial cell differentiation positive regulation of epidermal cell differentiation negative regulation of myoblast differentiation positive regulation of osteoblast differentiation positive regulation of ossification negative regulation of cell cycle negative regulation of mitotic nuclear division negative regulation of striated muscle tissue development negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lung alveolus development intermediate mesodermal cell differentiation positive regulation of smooth muscle cell proliferation neuron fate commitment embryonic cranial skeleton morphogenesis negative regulation of oligodendrocyte differentiation smooth muscle tissue development branching morphogenesis of an epithelial tube positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive chemotaxis regulation of smooth muscle cell differentiation response to glucocorticoid positive regulation of cardiac muscle fiber development anatomical structure regression retina development in camera-type eye inner ear receptor cell differentiation cloacal septation lens induction in camera-type eye embryonic skeletal joint morphogenesis cranial suture morphogenesis positive regulation of SMAD protein import into nucleus regulation of pathway-restricted SMAD protein phosphorylation SMAD protein signal transduction lung morphogenesis bronchus development trachea development trachea formation epithelial tube branching involved in lung morphogenesis branching involved in prostate gland morphogenesis bud elongation involved in lung branching lung lobe development epithelial cell proliferation involved in lung morphogenesis bud dilation involved in lung branching negative regulation of cell death mammary gland formation epithelial-mesenchymal cell signaling negative regulation of prostatic bud formation regulation of branching involved in prostate gland morphogenesis coronary vasculature development positive regulation of cartilage development positive regulation of branching involved in lung morphogenesis BMP signaling pathway involved in ureter morphogenesis BMP signaling pathway involved in renal system segmentation pulmonary artery endothelial tube morphogenesis BMP signaling pathway involved in heart development pharyngeal arch artery morphogenesis negative regulation of thymocyte apoptotic process positive regulation of hepatocyte differentiation positive regulation of ERK1 and ERK2 cascade cellular response to mechanical stimulus response to nitric oxide cellular response to BMP stimulus BMP signaling pathway involved in nephric duct formation renal system development glomerular visceral epithelial cell development negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway glomerular capillary formation negative regulation of glomerular mesangial cell proliferation mesenchymal cell proliferation involved in ureteric bud development mesenchymal cell differentiation involved in kidney development ureter epithelial cell differentiation ureter smooth muscle cell differentiation mesenchymal cell proliferation involved in ureter development negative regulation of mesenchymal cell proliferation involved in ureter development metanephric collecting duct development positive regulation of kidney development negative regulation of branching involved in ureteric bud morphogenesis negative regulation of glomerulus development cellular response to thyroid hormone stimulus positive regulation of store-operated calcium channel activity positive regulation of cell proliferation involved in outflow tract morphogenesis positive regulation of mesenchymal stem cell proliferation cardiac jelly development negative regulation of metanephric S-shaped body morphogenesis negative regulation of metanephric comma-shaped body morphogenesis positive regulation of DNA-dependent DNA replication negative regulation of cell proliferation involved in heart morphogenesis positive regulation of endothelial cell apoptotic process negative regulation of extrinsic apoptotic signaling pathway