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Product Details
H00000653-M51
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1G6
Immunogen
BMP5 (AAH27958.1, 323 a.a. approximately 422 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: NQNRNKSSSH QDSSRMSSVG DYNTSEQKQA CKKHELYVSF RDLGWQDWII APEGYAAFYC DGECSFPLNA HMNATNHAIV QTLVHLMFPD HVPKPCCAPT
Target Information
TGF-ß family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth, and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling, and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lungs and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP; BMP 5; BMP-5; bone morphogenenic protein-5; Bone morphogenetic protein; Bone morphogenetic protein 5; MGC34244
Gene Aliases: BMP5
UniProt ID: (Human) Q9H547
Entrez Gene ID: (Human) 653
skeletal system development
ossification
type B pancreatic cell development
pattern specification process
negative regulation of cell proliferation
negative regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of steroid biosynthetic process
BMP signaling pathway
male genitalia development
negative regulation of aldosterone biosynthetic process
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of insulin-like growth factor receptor signaling pathway
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
cartilage development
SMAD protein signal transduction
negative regulation of mononuclear cell migration
positive regulation of dendrite development
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of cortisol biosynthetic process
positive regulation of DNA-dependent DNA replication
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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