Proteintech

BMP7 Polyclonal Antibody

BMP7 Antibody in Immunocytochemistry (ICC/IF)

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BMP7 Antibody (12221-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 12221-1-AP (BMP7 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

BMP7 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

BMP7 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12221-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 13 publications 13 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BMP7 Fusion Protein Ag2902 (82-431 aa encoded by BC008584)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: FMLDLYNAM AVEEGGGPGG QGFSYPYKAV FSTQGPPLAS LQDSHFLTDA DMVMSFVNLV EHDKEFFHPR YHHREFRFDL SKIPEGEAVT AAEFRIYKDY IRERFDNETF RISVYQVLQE HLGRESDLFL LDSRTLWASE EGWLVFDITA TSNHWVVNPR HNLGLQLSVE TLDGQSINPK LAGLIGRHGP QNKQPFMVAF FKATEVHFRS IRSTGSKQRS QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY RNMVVRACGC H (82-431 aa encoded by BC008584)

Target Information

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extra skeletal site. Based on its expression early in embryogenesis, BMP7 has a proposed role in early development. In addition, the fact that BMP7 is closely related to BMP5 and BMP6 has lead to speculation of possible bone inductive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7.

Cellular and molecular life sciences : CMLS

Yang H,Song S,Li J,Li Y,Feng J,Sun Q,Qiu X,Chen Z,Bai X,Liu X,Lian H,Liu L,Bai Y,Zhang G,Nie Y

Wed Jun 21 00:00:00 EDT 2023

Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7.

Cellular and molecular life sciences : CMLS

Yang H,Song S,Li J,Li Y,Feng J,Sun Q,Qiu X,Chen Z,Bai X,Liu X,Lian H,Liu L,Bai Y,Zhang G,Nie Y

Wed Jun 21 00:00:00 EDT 2023

Huangqi decoction ameliorates kidney injury in db/db mice by regulating the BMP/Smad signaling pathway.

BMC complementary medicine and therapies

Chen Y,Rui R,Wang L,Wang H,Zhu B,Cao A

Mon Jun 26 00:00:00 EDT 2023

miR-122-5p targets GREM2 to protect against glucocorticoid-induced endothelial damage through the BMP signaling pathway.

Molecular and cellular endocrinology

Huang X,Jie S,Li W,Li H,Ni J,Liu C

Tue Mar 15 00:00:00 EDT 2022

BMP-7 Upregulates Id2 Through the MAPK Signaling Pathway to Improve Diabetic Tubulointerstitial Fibrosis and the Intervention of Oxymatrine.

Frontiers in pharmacology

Xiao Y,Liang D,Li Z,Feng Z,Yuan Z,Zhang F,Wang Y,Zhou Y,Shi M,Liu L,Xiao Y,Guo B

Sat Jul 16 00:00:00 EDT 2022

BMP-7 Upregulates Id2 Through the MAPK Signaling Pathway to Improve Diabetic Tubulointerstitial Fibrosis and the Intervention of Oxymatrine.

Frontiers in pharmacology

Xiao Y,Liang D,Li Z,Feng Z,Yuan Z,Zhang F,Wang Y,Zhou Y,Shi M,Liu L,Xiao Y,Guo B

Sat Jul 16 00:00:00 EDT 2022

BMP-7 Upregulates Id2 Through the MAPK Signaling Pathway to Improve Diabetic Tubulointerstitial Fibrosis and the Intervention of Oxymatrine.

Frontiers in pharmacology

Xiao Y,Liang D,Li Z,Feng Z,Yuan Z,Zhang F,Wang Y,Zhou Y,Shi M,Liu L,Xiao Y,Guo B

Sat Jul 16 00:00:00 EDT 2022

BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease.

Cell death & disease

Peng W,Zhou X,Xu T,Mao Y,Zhang X,Liu H,Liang L,Liu L,Liu L,Xiao Y,Zhang F,Li S,Shi M,Zhou Y,Tang L,Wang Y,Guo B

Mon Mar 21 00:00:00 EDT 2022

BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease.

Cell death & disease

Peng W,Zhou X,Xu T,Mao Y,Zhang X,Liu H,Liang L,Liu L,Liu L,Xiao Y,Zhang F,Li S,Shi M,Zhou Y,Tang L,Wang Y,Guo B

Mon Mar 21 00:00:00 EDT 2022

BMP-7 ameliorates partial epithelial-mesenchymal transition by restoring SnoN protein level via Smad1/5 pathway in diabetic kidney disease.

Cell death & disease

Peng W,Zhou X,Xu T,Mao Y,Zhang X,Liu H,Liang L,Liu L,Liu L,Xiao Y,Zhang F,Li S,Shi M,Zhou Y,Tang L,Wang Y,Guo B

Mon Mar 21 00:00:00 EDT 2022

LncRNA CRLM1 inhibits apoptosis and promotes metastasis through transcriptional regulation cooperated with hnRNPK in colorectal cancer.

Cell & bioscience

Wang Z,Chen J,Sun F,Zhao X,Dong Y,Yu S,Li J,Liang H

Sat Jul 30 00:00:00 EDT 2022

Concentrated small extracellular vesicles from menstrual blood-derived stromal cells improve intrauterine adhesion, a pre-clinical study in a rat model.

Nanoscale

Zhang S,Chang Q,Li P,Tong X,Feng Y,Hao X,Zhang X,Yuan Z,Tan J

Wed Apr 21 00:00:00 EDT 2021

Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.

Oncology reports

Li Q,Ma Y,Liu XL,Mu L,He BC,Wu K,Sun WJ

Sun Nov 01 00:00:00 EDT 2020

Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.

Oncology reports

Li Q,Ma Y,Liu XL,Mu L,He BC,Wu K,Sun WJ

Sun Nov 01 00:00:00 EDT 2020

A New Insight of Kartogenin Induced the Mesenchymal Stem Cells (MSCs) Selectively Differentiate into Chondrocytes by Activating the Bone Morphogenetic Protein 7 (BMP-7)/Smad5 Pathway.

Medical science monitor : international medical journal of experimental and clinical research

Zhou Q,Zhang JH,Yuan S,Shao JH,Cai ZY,Chen S,Cao J,Wu HS,Qian QR

Thu Jul 04 00:00:00 EDT 2019

BMP-7 inhibits renal fibrosis in diabetic nephropathy via miR-21 downregulation.

Life sciences

Liu L,Wang Y,Yan R,Liang L,Zhou X,Liu H,Zhang X,Mao Y,Peng W,Xiao Y,Zhang F,Liu L,Shi M,Guo B

Sun Dec 01 00:00:00 EST 2019

miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.

EBioMedicine

Wang M,Xiong L,Jiang LJ,Lu YZ,Liu F,Song LJ,Xiang F,He XL,Yu F,Shuai SY,Ma WL,Ye H

Fri Mar 01 00:00:00 EST 2019

miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.

EBioMedicine

Wang M,Xiong L,Jiang LJ,Lu YZ,Liu F,Song LJ,Xiang F,He XL,Yu F,Shuai SY,Ma WL,Ye H

Fri Mar 01 00:00:00 EST 2019

Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf.

Circulation research

Tan CY,Wong JX,Chan PS,Tan H,Liao D,Chen W,Tan LW,Ackers-Johnson M,Wakimoto H,Seidman JG,Seidman CE,Lunde IG,Zhu F,Hu Q,Bian J,Wang JW,Foo RS,Jiang J

Fri Oct 11 00:00:00 EDT 2019

Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7.

Frontiers in molecular neuroscience

Chen T,Wu Q,Zhang Y,Lu T,Yue W,Zhang D

Wed Sep 30 00:00:00 EDT 2020

Tcf4 Controls Neuronal Migration of the Cerebral Cortex through Regulation of Bmp7.

Frontiers in molecular neuroscience

Chen T,Wu Q,Zhang Y,Lu T,Yue W,Zhang D

Wed Sep 30 00:00:00 EDT 2020

MiR542-3p Regulates the Epithelial-Mesenchymal Transition by Directly Targeting BMP7 in NRK52e.

International journal of molecular sciences

Liu Z,Zhou Y,Yuan Y,Nie F,Peng R,Li Q,Lyu Z,Mao Z,Huang L,Zhou L,Li Y,Hao J,Ni D,Jin Q,Long Y,Ju P,Yu W,Liu J,Hu Y,Zhou Q

Tue Nov 24 00:00:00 EST 2015

MiR542-3p Regulates the Epithelial-Mesenchymal Transition by Directly Targeting BMP7 in NRK52e.

International journal of molecular sciences

Liu Z,Zhou Y,Yuan Y,Nie F,Peng R,Li Q,Lyu Z,Mao Z,Huang L,Zhou L,Li Y,Hao J,Ni D,Jin Q,Long Y,Ju P,Yu W,Liu J,Hu Y,Zhou Q

Tue Nov 24 00:00:00 EST 2015

Prognostic significance of BMP7 as an oncogene in hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Li W,Cai HX,Ge XM,Li K,Xu WD,Shi WH

Mon Apr 01 00:00:00 EDT 2013

Prognostic significance of BMP7 as an oncogene in hepatocellular carcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Li W,Cai HX,Ge XM,Li K,Xu WD,Shi WH

Mon Apr 01 00:00:00 EDT 2013

Bioinformatics

Protein Aliases: BMP; BMP-7; Bone morphogenetic protein; Bone morphogenetic protein 7; OP-1; Osteogenic protein 1; RP11-560A15.5

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Gene Aliases: Bmp-7; BMP7; OP-1; OP1

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UniProt ID: (Human) P18075, (Mouse) P23359

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Entrez Gene ID: (Human) 655, (Mouse) 12162

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Function(s)

cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity heparin binding BMP receptor binding growth factor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BMP7 Polyclonal Antibody

BMP7 Antibody (12221-1-AP) in ICC/IF

Product Details

12221-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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