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BMP9 Antibody (PA5-11931) in IHC (P)
Immunohistochemistry analysis of BMP9 in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with BMP9 polyclonal antibody (Product # PA5-11931) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepato... View More
Product Details
PA5-11931
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human BMP9 (GDF2)
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2111090
Target Information
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BMP; BMP-9; Bone morphogenetic protein; Bone morphogenetic protein 9; GDF-2; Growth/differentiation factor 2
Gene Aliases: BMP-9; BMP9; GDF2; HHT5
UniProt ID: (Human) Q9UK05, (Mouse) Q9WV56
Entrez Gene ID: (Human) 2658, (Mouse) 12165
ossification
angiogenesis
patterning of blood vessels
vasculogenesis
osteoblast differentiation
negative regulation of endothelial cell proliferation
positive regulation of endothelial cell proliferation
cellular iron ion homeostasis
negative regulation of DNA replication
negative regulation of endothelial cell migration
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of angiogenesis
negative regulation of cell growth
BMP signaling pathway
positive regulation of BMP signaling pathway
positive regulation of interleukin-8 production
activin receptor signaling pathway
growth
regulation of apoptotic process
regulation of MAPK cascade
negative regulation of blood vessel endothelial cell migration
positive regulation of endothelial cell differentiation
positive regulation of osteoblast differentiation
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
cell development
blood vessel morphogenesis
cartilage development
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
positive regulation of cartilage development
cellular response to BMP stimulus
negative regulation of DNA biosynthetic process
glucose metabolic process
positive regulation of gene expression
regulation of transforming growth factor beta receptor signaling pathway
neuron differentiation
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