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BMPR1A Polyclonal Antibody

BMPR1A Antibody in Immunocytochemistry (ICC/IF)

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BMPR1A Antibody (12702-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed U2OS cells using BMPR1A antibody (Product # 12702-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

BMPR1A Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

12702-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BMPR1A Fusion Protein Ag3410 (174-427 aa encoded by BC028383)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: FCYKHYCKS ISSRRRYNRD LEQDEAFIPV GESLKDLIDQ SQSSGSGSGL PLLVQRTIAK QIQMVRQVGK GRYGEVWMGK WRGEKVAVKV FFTTEEASWF RETEIYQTVL MRHENILGFI AADIKGTGSW TQLYLITDYH ENGSLYDFLK CATLDTRALL KLAYSAACGL CHLHTEIYGT QGKPAIAHRD LKSKNILIKK NGSCCIADLG LAVKFNSDTN EVDVPLNTRV GTKRYMAPEV LDESLNKNHF QPYIM (174-427 aa encoded by BC028383)

Target Information

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia.

EBioMedicine

Deng J,Zhao HJ,Zhong Y,Hu C,Meng J,Wang C,Lan X,Wang X,Chen ZJ,Yan J,Wang W,Li Y

Sat Jul 01 00:00:00 EDT 2023

LIM Mineralization Protein-1 Enhances the Committed Differentiation of Dental Pulp Stem Cells through the ERK1/2 and p38 MAPK Pathways and BMP Signaling.

International journal of medical sciences

Mu R,Chen B,Bi B,Yu H,Liu J,Li J,He M,Rong L,Liu B,Liu K,Zhu L,Shi X,Shuai Y,Jin L

Mon Aug 08 00:00:00 EDT 2022

Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels.

Biochimica et biophysica acta. General subjects

Huang T,Wu Q,Huang H,Zhang C,Wang L,Wang L,Liu Y,Li W,Zhang J,Liu Y

Sat Jan 01 00:00:00 EST 2022

Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.

Frontiers in cell and developmental biology

Shao C,Lou P,Liu R,Bi X,Li G,Yang X,Sheng X,Xu J,Lv C,Yu Z

Tue Aug 03 00:00:00 EDT 2021

Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland.

Frontiers in cell and developmental biology

Shao C,Lou P,Liu R,Bi X,Li G,Yang X,Sheng X,Xu J,Lv C,Yu Z

Tue Aug 03 00:00:00 EDT 2021

Next-Generation Sequencing Panel Analysis of Clinically Relevant Mutations in Circulating Cell-Free DNA from Patients with Gestational Trophoblastic Neoplasia: A Pilot Study.

BioMed research international

Luo L,Lin L,Zhang X,Cai Q,Zhao H,Xu C,Cong Q

Mon Sep 21 00:00:00 EDT 2020

Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells.

Science signaling

Gurrapu S,Franzolin G,Fard D,Accardo M,Medico E,Sarotto I,Sapino A,Isella C,Tamagnone L

Tue Aug 20 00:00:00 EDT 2019

A PINCH-1-Smurf1 signaling axis mediates mechano-regulation of BMPR2 and stem cell differentiation.

The Journal of cell biology

Guo L,Wang R,Zhang K,Yuan J,Wang J,Wang X,Ma J,Wu C

Mon Nov 04 00:00:00 EST 2019

Uterine ALK3 is essential during the window of implantation.

Proceedings of the National Academy of Sciences of the United States of America

Monsivais D,Clementi C,Peng J,Titus MM,Barrish JP,Creighton CJ,Lydon JP,DeMayo FJ,Matzuk MM

Tue Jan 19 00:00:00 EST 2016

Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells.

Scientific reports

Zeng Y,Liu H,Kang K,Wang Z,Hui G,Zhang X,Zhong J,Peng W,Ramchandran R,Raj JU,Gou D

Mon Jul 13 00:00:00 EDT 2015

Hypoxia inducible factor-1 mediates expression of miR-322: potential role in proliferation and migration of pulmonary arterial smooth muscle cells.

Scientific reports

Zeng Y,Liu H,Kang K,Wang Z,Hui G,Zhang X,Zhong J,Peng W,Ramchandran R,Raj JU,Gou D

Mon Jul 13 00:00:00 EDT 2015

Effect of miR-20b on Apoptosis, Differentiation, the BMP Signaling Pathway and Mitochondrial Function in the P19 Cell Model of Cardiac Differentiation In Vitro.

PloS one

Zhu S,Hu X,Yu Z,Peng Y,Zhu J,Liu X,Li M,Han S,Zhu C

Tue Apr 12 00:00:00 EDT 2016

Effect of miR-20b on Apoptosis, Differentiation, the BMP Signaling Pathway and Mitochondrial Function in the P19 Cell Model of Cardiac Differentiation In Vitro.

PloS one

Zhu S,Hu X,Yu Z,Peng Y,Zhu J,Liu X,Li M,Han S,Zhu C

Tue Apr 12 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMP-2/BMP-4 receptor; BMPR-1A; BMPRIA; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5

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Gene Aliases: 10q23del; 1110037I22Rik; ACVRLK3; ALK3; AU045487; Bmpr; BMPR-IA; BMPR1A; CD292; SKR5

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UniProt ID: (Human) P36894, (Mouse) P36895

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Entrez Gene ID: (Human) 657, (Mouse) 12166

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Function(s)

RNA polymerase II transcription factor activity, sequence-specific DNA binding glycoprotein binding protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding protein homodimerization activity SMAD binding metal ion binding BMP receptor activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BMPR1A Polyclonal Antibody

BMPR1A Antibody (12702-1-AP) in ICC/IF

Product Details

12702-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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