Invitrogen

BMPR1A Polyclonal Antibody

View all (14) BMPR1A antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-85369

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human BMPR1A.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2792511

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (99%), Rat (98%), Xenopus laevis (89%), Dog (99%), Pig (100%), Chicken (95%), Sheep (99%), Rhesus Monkey (100%), Bovine (98%).

Positive Control: human BMPR1A-transfected 293T.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMPR-1A; BMPRIA; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5

View more View less

Gene Aliases: 10q23del; ACVRLK3; ALK3; BMPR1A; CD292; SKR5

View more View less

UniProt ID: (Human) P36894

View more View less

Entrez Gene ID: (Human) 657

View more View less

Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding glycoprotein binding protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity receptor signaling protein serine/threonine kinase activity protein binding ATP binding protein homodimerization activity SMAD binding metal ion binding BMP receptor activity serine/threonine protein kinase receptor
Process(es)
in utero embryonic development mesoderm formation somitogenesis Mullerian duct regression positive regulation of mesenchymal cell proliferation chondrocyte differentiation outflow tract septum morphogenesis outflow tract morphogenesis cardiac conduction system development mitral valve morphogenesis tricuspid valve morphogenesis endocardial cushion morphogenesis cardiac right ventricle morphogenesis ventricular trabecula myocardium morphogenesis ventricular compact myocardium morphogenesis endocardial cushion formation protein phosphorylation immune response transforming growth factor beta receptor signaling pathway ectoderm development dorsal/ventral axis specification regulation of cardiac muscle cell apoptotic process positive regulation of pathway-restricted SMAD protein phosphorylation neural crest cell development negative regulation of smooth muscle cell migration stem cell population maintenance pituitary gland development neural plate mediolateral regionalization signal transduction by protein phosphorylation lung development positive regulation of bone mineralization BMP signaling pathway hindlimb morphogenesis dorsal aorta morphogenesis odontogenesis of dentin-containing tooth embryonic digit morphogenesis positive regulation of osteoblast differentiation positive regulation of transcription from RNA polymerase II promoter paraxial mesoderm structural organization lateral mesoderm development regulation of lateral mesodermal cell fate specification mesendoderm development embryonic organ development developmental growth positive regulation of epithelial cell proliferation negative regulation of neurogenesis palate development regulation of cardiac muscle cell proliferation positive regulation of cardiac muscle cell proliferation positive regulation of SMAD protein import into nucleus heart formation pharyngeal arch artery morphogenesis cellular response to BMP stimulus positive regulation of cardiac ventricle development positive regulation of vascular smooth muscle cell proliferation regulation of cellular senescence
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support