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Product Details
H00000657-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
4C4
Immunogen
BMPR1A (AAH28383, 1 a.a. approximately 532 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: MPQLYIYIRL LGAYLFIISR VQGQNLDSML HGTGMKSDSD QKKSENGVTL APEDTLPFLK CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLASGC MKYEGSGFQC KDSPKAQLRR TIECCRTNLC NQYLQPTLPP VVIGPFFDGS IRWLVLLISM AVCIIAMIIF SSCFCYKHYC KSISSRRRYN RDLEQDEAFI PVGESLKDLV DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDVPLNT RVGTKRYMAP EVLDESLNKN HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
Target Information
BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMPR-1A; BMPRIA; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
Gene Aliases: 10q23del; ACVRLK3; ALK3; BMPR1A; CD292; SKR5
UniProt ID: (Human) P36894
Entrez Gene ID: (Human) 657
RNA polymerase II transcription factor activity, sequence-specific DNA binding
glycoprotein binding
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
protein homodimerization activity
SMAD binding
metal ion binding
BMP receptor activity
serine/threonine protein kinase receptor
in utero embryonic development
mesoderm formation
somitogenesis
Mullerian duct regression
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
mitral valve morphogenesis
tricuspid valve morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
ventricular compact myocardium morphogenesis
endocardial cushion formation
protein phosphorylation
immune response
transforming growth factor beta receptor signaling pathway
ectoderm development
dorsal/ventral axis specification
regulation of cardiac muscle cell apoptotic process
positive regulation of pathway-restricted SMAD protein phosphorylation
neural crest cell development
negative regulation of smooth muscle cell migration
stem cell population maintenance
pituitary gland development
neural plate mediolateral regionalization
signal transduction by protein phosphorylation
lung development
positive regulation of bone mineralization
BMP signaling pathway
hindlimb morphogenesis
dorsal aorta morphogenesis
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
paraxial mesoderm structural organization
lateral mesoderm development
regulation of lateral mesodermal cell fate specification
mesendoderm development
embryonic organ development
developmental growth
positive regulation of epithelial cell proliferation
negative regulation of neurogenesis
palate development
regulation of cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
positive regulation of SMAD protein import into nucleus
heart formation
pharyngeal arch artery morphogenesis
cellular response to BMP stimulus
positive regulation of cardiac ventricle development
positive regulation of vascular smooth muscle cell proliferation
regulation of cellular senescence
Performance Guarantee
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