Invitrogen

BMPR2 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

View all (17) BMPR2 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-21437

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 667 and 951 of BMPR2 (Uniprot ID#Q13873)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_11152912

Product Specific Information

Recommended positive controls: HUVEC.

Predicted reactivity: Mouse (92%), Rat (92%), Pig (92%), Chicken (86%), Sheep (93%), Rhesus Monkey (98%), Bovine (93%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: BMP type II receptor; BMP type-2 receptor; BMPR-2; Bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4

View more View less

Gene Aliases: 2610024H22Rik; AL117858; AW546137; BB189135; BMP-2; BMPR-2; BMPR-II; BMPR2; BMPR3; BMPRII; BMR2; BRK-3; Gm20272; POVD1; PPH1; T-ALK

View more View less

UniProt ID: (Human) Q13873, (Mouse) O35607

View more View less

Entrez Gene ID: (Human) 659, (Rat) 140590, (Mouse) 12168

View more View less

Function(s)
receptor signaling protein serine/threonine kinase activity protein binding ATP binding activin receptor activity, type II growth factor binding BMP binding metal ion binding BMP receptor activity transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta-activated receptor activity nucleotide binding protein kinase activity protein serine/threonine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups serine/threonine protein kinase receptor
Process(es)
mesoderm formation maternal placenta development endothelial cell proliferation positive regulation of endothelial cell proliferation lymphangiogenesis blood vessel remodeling chondrocyte development negative regulation of systemic arterial blood pressure transcription from RNA polymerase II promoter transmembrane receptor protein serine/threonine kinase signaling pathway brain development cellular response to starvation anterior/posterior pattern specification positive regulation of endothelial cell migration positive regulation of epithelial cell migration positive regulation of pathway-restricted SMAD protein phosphorylation regulation of lung blood pressure signal transduction by protein phosphorylation proteoglycan biosynthetic process negative regulation of cell growth positive regulation of bone mineralization BMP signaling pathway positive regulation of BMP signaling pathway activin receptor signaling pathway regulation of cell proliferation positive regulation of osteoblast differentiation negative regulation of vasoconstriction positive regulation of transcription from RNA polymerase II promoter vascular endothelial growth factor receptor signaling pathway lung alveolus development positive regulation of axon extension involved in axon guidance limb development endochondral bone morphogenesis lymphatic endothelial cell differentiation artery development venous blood vessel development positive regulation of cartilage development retina vasculature development in camera-type eye cellular response to BMP stimulus endothelial cell apoptotic process negative regulation of chondrocyte proliferation negative regulation of DNA biosynthetic process protein phosphorylation retina development in camera-type eye positive regulation of protein phosphorylation phosphorylation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support