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Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. Fusion between endosomes and the vacuole will then target the cargo proteins to the vacuolar lumen (Probable). Associates with FREE1 and ELC to perform function in the ESCRT-I complex. Binds ubiquitin in vitro (PubMed:26902184). Plays a role in the biogenesis of vacuole and multivesicular bodies (MVBs) (PubMed:26342016, PubMed:26324913). Required for the endosomal location of AMSH3 (PubMed:26324913). Mediates high-affinity phosphate transporter trafficking to maintain phosphate homeostasis. Regulates vacuolar degradation of PHT1-1 (PubMed:26342016).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ALIX; AtBRO1; BRO domain-containing protein 1; SPHR1; Vacuolar-sorting protein BRO1
Gene Aliases: ALIX; AT1G15130; BRO1; F9L1.7; F9L1_7; SPHR1
UniProt ID: (Arabidopsis) F4HXZ1
Entrez Gene ID: (Arabidopsis) 838077
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