Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Reactivity occurs against human BRRN1 protein. However, BLAST analysis indicates 100% homology (18/18) for this protein from human, and chimpanzee. Partial cross reactivity is expected against mouse, dog, rat chicken, and from based on sequence homology of the amino terminal 13 amino acids of the immunogen sequence. The core 8 amino acids of the immunogen, A-G-P-D-H-W-R-F, show 100% identity with numerous proteins from a variety of organisms. If blots show multiple banding patterns in any particular lysate, it is suggested to confirm the specific reactivity against the BRRN1 protein using peptide competition. Reactivity with Brnn1 proteins from other sources is not known.
This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization.
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Protein Aliases: barren homolog 1; Barren homolog protein 1; Chromosome-associated protein H; Condensin complex subunit 2; hCAP-H; Non-SMC condensin I complex subunit H; non-SMC condensin I complex, subunit H; XCAP-H homolog
Gene Aliases: BRRN; BRRN1; CAP-H; CAPH; KIAA0074; NCAPH
UniProt ID: (Human) Q15003
Entrez Gene ID: (Human) 23397
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