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Product Details
PA5-20538
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid peptide near the amino terminus of the mouse Bst2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11152508
Product Specific Information
A suggested positive control is Daudi cell lysate.
PA5-20538 can be used with blocking peptide PEP-0658.
Target Information
BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bone marrow stromal antigen 2; BST-2; CD317; DAMP-1 protein homolog; HM1.24 antigen; NPC-A-7; PDCA-1; Tetherin
Gene Aliases: 2310015I10Rik; Bst-2; BST2; C87040; CD317; DAMP-1; GREG; TETHERIN
UniProt ID: (Human) Q10589, (Mouse) Q8R2Q8
Entrez Gene ID: (Human) 684, (Mouse) 69550
immune system process
response to virus
regulation of actin cytoskeleton organization
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
negative regulation of viral genome replication
innate immune response
defense response to virus
negative regulation of intracellular transport of viral material
negative regulation of plasmacytoid dendritic cell cytokine production
humoral immune response
cell-cell signaling
multicellular organism development
cell proliferation
negative regulation of endopeptidase activity
negative regulation of cell growth
negative regulation of cell migration
B cell activation
positive regulation of I-kappaB kinase/NF-kappaB signaling
type I interferon signaling pathway
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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