Proteintech

BST2 Polyclonal Antibody

BST2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 10

BST2 Antibody (13560-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 13560-1-AP (BST2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

BST2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

13560-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 18 publications 18 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 6 publications 6 publications

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BST2 Fusion Protein Ag4430 (1-180 aa encoded by BC033873)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASTSYDYC RVPMEDGDKR CKLLLGIGIL VLLIIVILGV PLIIFTIKAN SEACRDGLRA VMECRNVTHL LQQELTEAQK GFQDVEAQAA TCNHTVMALM ASLDAEKAQG QKKVEELEGE ITTLNHKLQD ASAEVERLRR ENQVLSVRIA DKKYYPSSQD SSSAAAPQLL IVLLGLSALL Q (1-180 aa encoded by BC033873)

Target Information

BST2 (CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein that is involved in the development and growth of B-cells. The surface expression of BST2 on fibroblast cell lines facilitated the stromal cell-dependent growth of DW34, a pre-B-cell line. BST2 is highly expressed during B-cell development, from pro-B precursors to plasma cells, T-cells, monocytes, NK cells and DCs (at protein level), and myeloma cells. Research studies have shown that BST2 also functions as an inhibitor of retrovirus release from human cells whose activity is antagonized by the HIV-1 accessory protein, Vpu. While BST2 causes retention of virions on cell surfaces or endocytosis into BST2-positive compartments, its depletion abolished the viral requirement for Vpu for virus release, an activity that may represent a potential therapeutic strategy for the treatment of HIV/AIDS. Another disease associated with BST2 dysfunction is stomatitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation.

Cell death & disease

Cheng J,Zhang G,Deng T,Liu Z,Zhang M,Zhang P,Adeshakin FO,Niu X,Yan D,Wan X,Yu G

Sat May 20 00:00:00 EDT 2023

CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation.

Cell death & disease

Cheng J,Zhang G,Deng T,Liu Z,Zhang M,Zhang P,Adeshakin FO,Niu X,Yan D,Wan X,Yu G

Sat May 20 00:00:00 EDT 2023

CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation.

Cell death & disease

Cheng J,Zhang G,Deng T,Liu Z,Zhang M,Zhang P,Adeshakin FO,Niu X,Yan D,Wan X,Yu G

Sat May 20 00:00:00 EDT 2023

CD317 maintains proteostasis and cell survival in response to proteasome inhibitors by targeting calnexin for RACK1-mediated autophagic degradation.

Cell death & disease

Cheng J,Zhang G,Deng T,Liu Z,Zhang M,Zhang P,Adeshakin FO,Niu X,Yan D,Wan X,Yu G

Sat May 20 00:00:00 EDT 2023

BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.

International journal of oncology

Shan F,Shen S,Wang X,Chen G

Sat Apr 01 00:00:00 EDT 2023

BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway.

International journal of oncology

Shan F,Shen S,Wang X,Chen G

Sat Apr 01 00:00:00 EDT 2023

Identification of BST2 Contributing to the Development of Glioblastoma Based on Bioinformatics Analysis.

Frontiers in genetics

Kong Y,Xue Z,Wang H,Cui G,Chen A,Liu J,Wang J,Li X,Huang B

Sat Jul 23 00:00:00 EDT 2022

Catch Me if You Can: the Crosstalk of Zika Virus and the Restriction Factor Tetherin.

Journal of virology

Herrlein ML,Schmanke P,Elgner F,Sabino C,Akhras S,Bender D,Glitscher M,Tabari D,Scholl C,Stingl J,Hildt E

Wed Feb 23 00:00:00 EST 2022

Catch Me if You Can: the Crosstalk of Zika Virus and the Restriction Factor Tetherin.

Journal of virology

Herrlein ML,Schmanke P,Elgner F,Sabino C,Akhras S,Bender D,Glitscher M,Tabari D,Scholl C,Stingl J,Hildt E

Wed Feb 23 00:00:00 EST 2022

BST2 Suppresses LINE-1 Retrotransposition by Reducing the Promoter Activity of LINE-1 5' UTR.

Journal of virology

Zhao Y,Du J,Wang Y,Wang Q,Wang S,Zhao K

Wed Jan 26 00:00:00 EST 2022

The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface.

Current biology : CB

Presle A,Frémont S,Salles A,Commere PH,Sassoon N,Berlioz-Torrent C,Gupta-Rossi N,Echard A

Mon May 24 00:00:00 EDT 2021

The viral restriction factor tetherin/BST2 tethers cytokinetic midbody remnants to the cell surface.

Current biology : CB

Presle A,Frémont S,Salles A,Commere PH,Sassoon N,Berlioz-Torrent C,Gupta-Rossi N,Echard A

Mon May 24 00:00:00 EDT 2021

Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses.

Frontiers in immunology

Gao W,Rui Y,Li G,Zhai C,Su J,Liu H,Zheng W,Zheng B,Zhang W,Yang Y,Hua S,Yu X

Wed Jan 05 00:00:00 EST 2022

ATP1B3 cooperates with BST-2 to promote hepatitis B virus restriction.

Journal of medical virology

Zheng B,Zhang J,Zheng T,Wang H,Li Z,Huan C,Ning S,Wang Y,Zhang W

Sat Feb 01 00:00:00 EST 2020

MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer.

Journal of biochemistry

Liu W,Li Y,Feng S,Guan Y,Cao Y

Sat Aug 01 00:00:00 EDT 2020

Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2.

Journal of virology

Heusinger E,Deppe K,Sette P,Krapp C,Kmiec D,Kluge SF,Marx PA,Apetrei C,Kirchhoff F,Sauter D

Sat Sep 15 00:00:00 EDT 2018

Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2.

Journal of virology

Heusinger E,Deppe K,Sette P,Krapp C,Kmiec D,Kluge SF,Marx PA,Apetrei C,Kirchhoff F,Sauter D

Sat Sep 15 00:00:00 EDT 2018

BST2 promotes cell proliferation, migration and induces NF-κB activation in gastric cancer.

Biotechnology letters

Liu W,Cao Y,Guan Y,Zheng C

Sun Jul 01 00:00:00 EDT 2018

BST2 promotes cell proliferation, migration and induces NF-κB activation in gastric cancer.

Biotechnology letters

Liu W,Cao Y,Guan Y,Zheng C

Sun Jul 01 00:00:00 EDT 2018

BST2 promotes cell proliferation, migration and induces NF-κB activation in gastric cancer.

Biotechnology letters

Liu W,Cao Y,Guan Y,Zheng C

Sun Jul 01 00:00:00 EDT 2018

BST2 promotes cell proliferation, migration and induces NF-κB activation in gastric cancer.

Biotechnology letters

Liu W,Cao Y,Guan Y,Zheng C

Sun Jul 01 00:00:00 EDT 2018

Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.

Molecular cell

Jin S,Tian S,Luo M,Xie W,Liu T,Duan T,Wu Y,Cui J

Thu Oct 19 00:00:00 EDT 2017

Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells.

Molecular cell

Jin S,Tian S,Luo M,Xie W,Liu T,Duan T,Wu Y,Cui J

Thu Oct 19 00:00:00 EDT 2017

Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.

PLoS pathogens

Fu Y,Zhang L,Zhang F,Tang T,Zhou Q,Feng C,Jin Y,Wu Z

Fri Sep 01 00:00:00 EDT 2017

Exosome-mediated miR-146a transfer suppresses type I interferon response and facilitates EV71 infection.

PLoS pathogens

Fu Y,Zhang L,Zhang F,Tang T,Zhou Q,Feng C,Jin Y,Wu Z

Fri Sep 01 00:00:00 EDT 2017

The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion.

Journal of virology

Yan R,Zhao X,Cai D,Liu Y,Block TM,Guo JT,Guo H

Tue Sep 01 00:00:00 EDT 2015

The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion.

Journal of virology

Yan R,Zhao X,Cai D,Liu Y,Block TM,Guo JT,Guo H

Tue Sep 01 00:00:00 EDT 2015

The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion.

Journal of virology

Yan R,Zhao X,Cai D,Liu Y,Block TM,Guo JT,Guo H

Tue Sep 01 00:00:00 EDT 2015

The Interferon-Inducible Protein Tetherin Inhibits Hepatitis B Virus Virion Secretion.

Journal of virology

Yan R,Zhao X,Cai D,Liu Y,Block TM,Guo JT,Guo H

Tue Sep 01 00:00:00 EDT 2015

Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.

Proceedings of the National Academy of Sciences of the United States of America

Zhao X,Guo F,Liu F,Cuconati A,Chang J,Block TM,Guo JT

Tue May 06 00:00:00 EDT 2014

Interferon induction of IFITM proteins promotes infection by human coronavirus OC43.

Proceedings of the National Academy of Sciences of the United States of America

Zhao X,Guo F,Liu F,Cuconati A,Chang J,Block TM,Guo JT

Tue May 06 00:00:00 EDT 2014

Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.

Biochemical and biophysical research communications

Zhang W,Zhang L,Wu Z,Tien P

Fri May 09 00:00:00 EDT 2014

Differential interferon pathway gene expression patterns in Rhabdomyosarcoma cells during Enterovirus 71 or Coxsackievirus A16 infection.

Biochemical and biophysical research communications

Zhang W,Zhang L,Wu Z,Tien P

Fri May 09 00:00:00 EDT 2014

BST2/Tetherin inhibits hepatitis C virus production in human hepatoma cells.

Antiviral research

Pan XB,Qu XW,Jiang D,Zhao XL,Han JC,Wei L

Mon Apr 01 00:00:00 EDT 2013

BST2/Tetherin inhibits hepatitis C virus production in human hepatoma cells.

Antiviral research

Pan XB,Qu XW,Jiang D,Zhao XL,Han JC,Wei L

Mon Apr 01 00:00:00 EDT 2013

BST2/Tetherin inhibits hepatitis C virus production in human hepatoma cells.

Antiviral research

Pan XB,Qu XW,Jiang D,Zhao XL,Han JC,Wei L

Mon Apr 01 00:00:00 EDT 2013

BST2/Tetherin inhibits hepatitis C virus production in human hepatoma cells.

Antiviral research

Pan XB,Qu XW,Jiang D,Zhao XL,Han JC,Wei L

Mon Apr 01 00:00:00 EDT 2013

BST2/tetherin inhibits dengue virus release from human hepatoma cells.

PloS one

Pan XB,Han JC,Cong X,Wei L

Fri May 24 00:00:00 EDT 2013

BST2/tetherin inhibits dengue virus release from human hepatoma cells.

PloS one

Pan XB,Han JC,Cong X,Wei L

Fri May 24 00:00:00 EDT 2013

BST2/tetherin inhibits dengue virus release from human hepatoma cells.

PloS one

Pan XB,Han JC,Cong X,Wei L

Fri May 24 00:00:00 EDT 2013

BST2/tetherin inhibits dengue virus release from human hepatoma cells.

PloS one

Pan XB,Han JC,Cong X,Wei L

Fri May 24 00:00:00 EDT 2013

Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.

Journal of virology

Weidner JM,Jiang D,Pan XB,Chang J,Block TM,Guo JT

Wed Dec 01 00:00:00 EST 2010

Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.

Journal of virology

Weidner JM,Jiang D,Pan XB,Chang J,Block TM,Guo JT

Wed Dec 01 00:00:00 EST 2010

Bioinformatics

Protein Aliases: Bone marrow stromal antigen 2; BST-2; CD317; DAMP-1 protein homolog; HM1.24 antigen; NPC-A-7; PDCA-1; Tetherin

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Gene Aliases: 2310015I10Rik; Bst-2; BST2; C87040; CD317; DAMP-1; GREG; TETHERIN

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UniProt ID: (Human) Q10589, (Mouse) Q8R2Q8

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Entrez Gene ID: (Human) 684, (Mouse) 69550

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Function(s)

signal transducer activity protein binding metalloendopeptidase inhibitor activity protein homodimerization activity poly(A) RNA binding

Process(es)

immune system process response to virus regulation of actin cytoskeleton organization response to interferon-gamma response to interferon-alpha response to interferon-beta negative regulation of viral genome replication innate immune response defense response to virus negative regulation of intracellular transport of viral material negative regulation of plasmacytoid dendritic cell cytokine production humoral immune response cell-cell signaling multicellular organism development cell proliferation negative regulation of endopeptidase activity negative regulation of cell growth negative regulation of cell migration B cell activation positive regulation of I-kappaB kinase/NF-kappaB signaling type I interferon signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BST2 Polyclonal Antibody

BST2 Antibody (13560-1-AP) in ICC/IF

Product Details

13560-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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