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The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene and the BTN2 and BTN3 genes, which have undergone tandem duplication, resulting in 3 copies of each.
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Protein Aliases: butyrophilin; Butyrophilin subfamily 3 member A1; butyrophilin, subfamily 3, member A1; CD277; dJ45P21.3 (butyrophilin, subfamily 3, member A1)
Gene Aliases: BT3.1; BTF5; BTN3.1; BTN3A1; CD277
UniProt ID: (Human) O00481
Entrez Gene ID: (Human) 11119
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