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Product Details
PA5-56680
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BYSL. Recombinant protein control fragment (Product #RP-94699).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2638649
Product Specific Information
Immunogen sequence: QQQEELEAEH GTGDKPAAPR ERTTRLGPRM PQDGSDDEDE EWPTLEKAAT MTAAGHHAEV VVDPEDERAI EMFMNKNPPA R
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 83%.
Target Information
Bystin is expressed as a 2-kb major transcript and a 3.6-kb minor transcript in SNG-M cells and in human trophoblastic teratocarcinoma HT-H cells. Protein binding assays determined that bystin binds directly to trophinin and tastin, and that binding is enhanced when cytokeratins 8 and 18 are present. Immunocytochemistry of HT-H cells showed that bystin colocalizes with trophinin, tastin, and the cytokeratins, suggesting that these molecules form a complex in trophectoderm cells at the time of implantation. Using immunohistochemistry it was determined that trophinin and bystin are found in the placenta from the sixth week of pregnancy. Both proteins were localized in the cytoplasm of the syncytiotrophoblast in the chorionic villi and in endometrial decidual cells at the uteroplacental interface. After week 10, the levels of trophinin, tastin, and bystin decreased and then disappeared from placental villi.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: by the ribosomal protein s6 gene, drosophila, homolog-like; Bystin; bystin-like
Gene Aliases: BYSL; BYSTIN; ENP1
UniProt ID: (Human) Q13895
Entrez Gene ID: (Human) 705
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
trophectodermal cell differentiation
rRNA processing
cell adhesion
brain development
female pregnancy
cell proliferation
neuron differentiation
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to growth factor stimulus
cellular response to organic cyclic compound
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