Invitrogen

Bax Monoclonal Antibody (2D2)

Advanced Verification

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

5 Published Figures

59 References

View all (99) BAX antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Datasheet

Protocols

Questions & Answers

Tech Support

Bax Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

Bax Antibody (MA5-13994) in IHC (P)

Formalin-fixed, paraffin-embedded human Hodgkin’s lymphoma stained with Bax antibody using peroxidase-conjugate and DAB chromogen. Note membrane staining of Reedternberg cells.

Bax Antibody in Immunohistochemistry (IHC)

Product Image Gallery

Bax Antibody — Antibody specificity was demonstrated by CRISPR-Cas9 mediated knockout of target protein. A loss of signal was observed for target protein in BAX KO cell line compared to control cell line using Anti- Bax Monoclonal Antibody (2D2) (Product # MA5-13994). {KO}

Product Details

MA5-13994

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

View 19 publications 19 publications

Immunohistochemistry (IHC)

View 28 publications 28 publications

Immunohistochemistry (Paraffin) (IHC (P))

2-4 µg/mL

View 2 publications 2 publications

Immunohistochemistry - Free Floating (IHC (Free))

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Miscellaneous PubMed (Misc)

View 4 publications 4 publications

Product Specifications

Species Reactivity

Human

Published species

Bovine, Donkey, Human, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2D2

Immunogen

A synthetic peptide, aa 3-16 (Cys-GSGEQPRGGGPTSS) of human bax protein. This amino acid sequence is NOT shared by mouse and rat bax protein.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11004781

Product Specific Information

MA5-13994 targets Bax in IF, IHC (P), and WB applications and shows reactivity with Human samples.

The MA5-13994 immunogen is a synthetic peptide, aa 3-16 (Cys-GSGEQPRGGGPTSS) of human bax protein. This amino acid sequence is NOT shared by mouse and rat bax protein.

Target Information

BAX is a members of the Bcl-2 Family and plays an important role in regulation of apoptosis. Whereas Bcl-2 is commonly regarded as an anti-apoptotic protein, BAX is considered to have a pro-apoptotic function. Regulation of apoptosis is supposed to involve both homo- and heterodimerization of different isoforms of BAX and Bcl-2. The Bax gene encodes different isoforms including Bax alpha (21 kDa) and Bax beta (24 kDa), whereas both isoforms contain the BH1, BH2 and BH3 domains, Bax beta has a unique carboxyl terminus and does not contain a hydrophobic transmembrane domain. Bcl-2 is also expressed in different Isoforms. Bcl-2 beta differs in the 3' UTR and coding region compared to variant alpha. Bcl-2 beta is shorter (22 kDa) and has a distinct C-terminus compared to Bcl-2 alpha (26 kDa). BAX is a member of the BCL-2 family of proteins, which function as regulators of apoptosis. Overexpression of BAX functions to promote cell death. BAX can form homodimers and is also able to heterodimerize with other BCL-2 related proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a Model of Steatohepatitis.

Biomedicines

Shunkina D,Dakhnevich A,Shunkin E,Khaziakhmatova O,Shupletsova V,Vulf M,Komar A,Kirienkova E,Litvinova L

MA5-13994 was used in Immunohistochemistry (Paraffin), Western Blot to investigate the effect of gp130 on the components of mitochondrial dynamics in a cellular model of steatohepatitis.

Sun Jan 29 00:00:00 EST 2023

Reproduction in domestic animals = Zuchthygiene

Masoud SR,Kishta AA,Canisso IF,Abdel-Megeid NS,Fathalla SI,Shawky SM,Abdoon ASS

MA5-13994 was used in Immunohistochemistry to conclude that advancement of age affects the testicular morphometry and function in donkeys.

Tue Nov 01 00:00:00 EDT 2022

miR‑205‑3p promotes lung cancer progression by targeting APBB2.

Molecular medicine reports

Xu LB,Xiong J,Zhang YH,Dai Y,Ren XP,Ren YJ,Han D,Wei SH,Qi M

Published figure using Bax monoclonal antibody (Product # MA5-13994) in Western Blot

Sun Aug 01 00:00:00 EDT 2021

Circ_CLASP2 Regulates High Glucose-Induced Dysfunction of Human Endothelial Cells Through Targeting miR-140-5p/FBXW7 Axis.

Frontiers in pharmacology

Zhang Q,Long J,Li N,Ma X,Zheng L

MA5-13994 was used in Western Blot to suggest that the overexpression of circ_CLASP2 protected HUVEC from HG-induced dysfunction at least partly through the regulation of the miR-140-5p/FBXW7 axis.

Tue Mar 30 00:00:00 EDT 2021

Circ_CLASP2 Regulates High Glucose-Induced Dysfunction of Human Endothelial Cells Through Targeting miR-140-5p/FBXW7 Axis.

Frontiers in pharmacology

Zhang Q,Long J,Li N,Ma X,Zheng L

MA5-13994 was used in Western Blot to suggest that the overexpression of circ_CLASP2 protected HUVEC from HG-induced dysfunction at least partly through the regulation of the miR-140-5p/FBXW7 axis.

Tue Mar 30 00:00:00 EDT 2021

Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis.

Cell death and differentiation

Raemy E,Montessuit S,Pierredon S,van Kampen AH,Vaz FM,Martinou JC

MA5-13994 was used in immunocytochemistry to research tBID receptors served by MTCH2 or Cardiolipin during apoptosis

Fri Jul 01 00:00:00 EDT 2016

Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis.

BioMed research international

Li Y,Ma H,Lu Y,Tan BJ,Xu L,Lawal TO,Mahady GB,Liu D

MA5-13994 was used in Immunohistochemistry-immunofluorescence to demonstrate that Menoprogen inhibits granulosa cell apoptosis in aged female rats and thereby increases E2 production.

Tue Dec 13 00:00:00 EST 2016

Menoprogen, a TCM Herbal Formula for Menopause, Increases Endogenous E2 in an Aged Rat Model of Menopause by Reducing Ovarian Granulosa Cell Apoptosis.

BioMed research international

Li Y,Ma H,Lu Y,Tan BJ,Xu L,Lawal TO,Mahady GB,Liu D

MA5-13994 was used in Immunohistochemistry-immunofluorescence to demonstrate that Menoprogen inhibits granulosa cell apoptosis in aged female rats and thereby increases E2 production.

Tue Dec 13 00:00:00 EST 2016

The protective effects of carnosine in alcohol-induced hepatic injury in rats.

Toxicology and industrial health

Baykara B,Micili SC,Tugyan K,Tekmen I,Bagriyanik H,Sonmez U,Sonmez A,Oktay G,Yener N,Ozbal S

MA5-13994 was used in immunohistochemistry to study the mechanisms underlying the protective effects of carnosine in a rat model of alcohol-induced liver damage

Sat Feb 01 00:00:00 EST 2014

Combination of molecular alterations and smoking intensity predicts bladder cancer outcome: a report from the Los Angeles Cancer Surveillance Program.

Cancer

Mitra AP,Castelao JE,Hawes D,Tsao-Wei DD,Jiang X,Shi SR,Datar RH,Skinner EC,Stein JP,Groshen S,Yu MC,Ross RK,Skinner DG,Cortessis VK,Cote RJ

MA5-13994 was used in immunohistochemistry to study the value of a panel of 9 biomarkers plus smoking intensity in predicting the outcome of bladder cancer

Fri Feb 15 00:00:00 EST 2013

Low-dose anisomycin sensitizes melanoma cells to TRAIL induced apoptosis.

Cancer biology & therapy

Slipicevic A,Øy GF,Rosnes AK,Stakkestad Ø,Emilsen E,Engesæter B,Mælandsmo GM,Flørenes VA

MA5-13994 was used in western blot to study the mechanism underlying the synergistic effects of anisomycin plus lexatumumab against metastatic melanoma cells

Fri Feb 01 00:00:00 EST 2013

Exon-skipping strategy by ratio modulation between cytoprotective versus pro-apoptotic clusterin forms increased sensitivity of LNCaP to cell death.

PloS one

Essabbani A,Garcia L,Zonetti MJ,Fisco T,Pucci S,Chiocchia G

MA5-13994 was used in western blot to study the increased sensitivity to chemotherapy and radiotherapy of prostate cancer cells in which the ratio of nuclear:secreted clusterin is experimentally elevated

Fri Aug 09 00:00:00 EDT 2013

The effects of short-term genistein intervention on prostate biomarker expression in patients with localised prostate cancer before radical prostatectomy.

The British journal of nutrition

Lazarevic B,Hammarström C,Yang J,Ramberg H,Diep LM,Karlsen SJ,Kucuk O,Saatcioglu F,Taskèn KA,Svindland A

MA5-13994 was used in immunohistochemistry to study the effects of short-term genistein intervention on the expression of prostate biomarkers in patients with localised prostate cancer

Fri Dec 28 00:00:00 EST 2012

Significance of decreased apoptosis, role of Bid expression and Bcl-Xl/Bid ratio in human jejunal stromal tumors.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

Gao C,Guo WJ,Wang AY

MA5-13994 was used in immunohistochemistry to study the significance of apoptosis and the role Bid expression in human jejunal stromal tumors

Thu Mar 01 00:00:00 EST 2012

Molecular profiling of parathyroid hyperplasia, adenoma and carcinoma.

Pathology oncology research : POR

Árvai K,Nagy K,Barti-Juhász H,Peták I,Krenács T,Micsik T,Végső G,Perner F,Szende B

MA5-13994 was used in immunohistochemistry to study the molecular profiles of parathyroid hyperplasia, adenoma and carcinoma

Sun Jul 01 00:00:00 EDT 2012

Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors.

Diagnostic pathology

Ozer H,Yenicesu G,Arici S,Cetin M,Tuncer E,Cetin A

MA5-13994 was used in immunohistochemistry to study the diagnostic value of the immunohistochemical expression of apoptotic and anti-apoptotic markers in serous and mucinous ovarian tumors

Thu Sep 20 00:00:00 EDT 2012

NDV-induced apoptosis in absence of Bax; evidence of involvement of apoptotic proteins upstream of mitochondria.

Virology journal

Molouki A,Yusoff K

MA5-13994 was used in Western Blotting to investigate the role of members of the Bcl-2 family in Newcastle disease virus-induced apoptosis.

Thu Aug 30 00:00:00 EDT 2012

Human mesenchymal stem cells play a dual role on tumor cell growth in vitro and in vivo.

Journal of cellular physiology

Tian LL,Yue W,Zhu F,Li S,Li W

MA5-13994 was used in western blot to study the role of human mesenchymal stem cells in the growth of tumors in vitro and in vivo

Fri Jul 01 00:00:00 EDT 2011

Implications of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy.

Indian journal of dermatology

Aydin F,Levent Y,Nilgun S,Pancar YE,Yasar TA

MA5-13994 was used in immunohistochemistry to study the role of bax, fas, and p53 in the pathogenesis of early-stage mycosis fungoides and alterations in expression following photochemotherapy

Thu Aug 23 00:00:00 EDT 2012

Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma.

Liver international : official journal of the International Association for the Study of the Liver

Yu F,Hao X,Zhao H,Ge C,Yao M,Yang S,Li J

MA5-13994 was used in western blot to study the mechanism by which Delta-like 1 contributes to cell growth in hepatocellular carcinoma

Sat May 01 00:00:00 EDT 2010

4'-Chloro-3,5-dihydroxystilbene, a resveratrol derivative, induces lung cancer cell death.

Acta pharmacologica Sinica

Wu JY,Tsai KW,Shee JJ,Li YZ,Chen CH,Chuang JJ,Liu YW

MA5-13994 was used in western blot to study the antitumor effect of the resveratrol derivative 4'-chloro-3,5-dihydroxystilbene on a lung adenocarcinoma cell line

Fri Jan 01 00:00:00 EST 2010

Prognostic significance of apoptotic cell death in bladder cancer: a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens.

Pathology

Karamitopoulou E,Rentsch CA,Markwalder R,Vallan C,Thalmann GN,Brunner T

MA5-13994 was used in immunohistochemistry to study the prognostic significance of apoptosis-related markers in bladder cancer

Fri Jan 01 00:00:00 EST 2010

Translocation of p53 to mitochondria is regulated by its lipid binding property to anionic phospholipids and it participates in cell death control.

Neoplasia (New York, N.Y.)

Li CH,Cheng YW,Liao PL,Kang JJ

MA5-13994 was used in western blot to study the role of p53 in apoptosis

Mon Feb 01 00:00:00 EST 2010

Interleukin-6 affects cell death escaping mechanisms acting on Bax-Ku70-Clusterin interactions in human colon cancer progression.

Cell cycle (Georgetown, Tex.)

Pucci S,Mazzarelli P,Sesti F,Boothman DA,Spagnoli LG

Published figure using Bax monoclonal antibody (Product # MA5-13994) in Immunohistochemistry

Sun Feb 01 00:00:00 EST 2009

Significance of increased apoptosis and Bax expression in human small intestinal adenocarcinoma.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

Gao C,Wang AY

MA5-13994 was used in immunohistochemistry to study the significance of apoptosis and Bax expression levels for the low incidence of human small intestinal tumors

Tue Dec 01 00:00:00 EST 2009

Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells.

Biochemical and biophysical research communications

Lin YJ,Hou YC,Lin CH,Hsu YA,Sheu JJ,Lai CH,Chen BH,Lee Chao PD,Wan L,Tsai FJ

MA5-13994 was used in western blot to study the effect of Puerariae radix isoflavones on growth and apoptosis in breast cancer cells

Fri Jan 23 00:00:00 EST 2009

Expression of the antiapoptosis gene Survivin predicts poor prognosis of stage III gastric adenocarcinoma.

Japanese journal of clinical oncology

Song KY,Jung CK,Park WS,Park CH

MA5-13994 was used in immunohistochemistry to investigate the prognostic significance of survivin in stage III gastric adenocarcinoma

Fri May 01 00:00:00 EDT 2009

Effect of fetal sex on apoptosis-regulating proteins in trophoblasts of full-term human placenta.

Gynecologic and obstetric investigation

Gol M,Tuna B

MA5-13994 was used in immunohistochemistry to study the effect of fetal sex on apoptosis-regulating proteins in trophoblasts of full-term human placenta

Thu Apr 23 00:00:00 EDT 2009

A phase I pharmacokinetic and pharmacodynamic correlative study of the antisense Bcl-2 oligonucleotide g3139, in combination with carboplatin and paclitaxel, in patients with advanced solid tumors.

Clinical cancer research : an official journal of the American Association for Cancer Research

Liu G,Kolesar J,McNeel DG,Leith C,Schell K,Eickhoff J,Lee F,Traynor A,Marnocha R,Alberti D,Zwiebel J,Wilding G

MA5-13994 was used in Immunohistochemistry to assess the safety and tolerability of G3139 when given in combination with carboplatin and paclitaxel chemotherapy in patients with advanced solid tumours.

Thu May 01 00:00:00 EDT 2008

Identification of immunohistochemical biomarkers for papillary thyroid carcinoma using gene expression profiling.

Human pathology

Murphy KM,Chen F,Clark DP

MA5-13994 was used in immunohistochemistry to identify the diagnostic markers for papillary thyroid carcinoma

Sat Mar 01 00:00:00 EST 2008

Microwave antigen retrieval blocks endogenous peroxidase activity in immunohistochemistry.

Applied immunohistochemistry & molecular morphology : AIMM

Gao C,Wang AY,Han YJ

MA5-13994 was used in immunohistochemistry to study the inhibitory effect of microwave antigen retrieval on endogenous peroxidase activity in immunohistochemistry

Tue Jul 01 00:00:00 EDT 2008

Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity.

Molecular and cellular biochemistry

Mukherjee Nee Chakraborty S,Ghosh U,Bhattacharyya NP,Bhattacharya RK,Dey S,Roy M

MA5-13994 was used in western blot to study the potential role of telomerase inhibition in the pro-apoptotic effects of curcumin in a human leukemic cell line

Thu Mar 01 00:00:00 EST 2007

Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage.

Ophthalmic research

Ricci F,Pucci S,Sesti F,Missiroli F,Cerulli L,Spagnoli LG

MA5-13994 was used in immunocytochemistry to study the molecular mechanisms underlying indocyanine-green-mediated photo-oxidative cell damage

Thu Aug 23 00:00:00 EDT 2007

Prognostic significance of cell proliferation and apoptosis-regulating proteins in Epstein-Barr virus positive and negative pediatric Hodgkin lymphoma.

Lymphatic research and biology

Aktaş S,Kargi A,Olgun N,Diniz G,Erbay A,Vergin C

MA5-13994 was used in immunohistochemistry to evaluate prognostic markers for Epstein-Barr virus positive and negative pediatric Hodgkin lymphoma

Mon Mar 03 00:00:00 EST 2008

A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins.

Journal of hepatology

Nishikawa T,Nakajima T,Moriguchi M,Jo M,Sekoguchi S,Ishii M,Takashima H,Katagishi T,Kimura H,Minami M,Itoh Y,Kagawa K,Okanoue T

MA5-13994 was used in western blot to study the mechanism by which a green tea polyphenol induces apoptosis of human hepatocellular carcinoma

Thu Jun 01 00:00:00 EDT 2006

Silencing of astrin induces the p53-dependent apoptosis by suppression of HPV18 E6 expression and sensitizes cells to paclitaxel treatment in HeLa cells.

Biochemical and biophysical research communications

Yang YC,Hsu YT,Wu CC,Chen HT,Chang MS

MA5-13994 was used in western blot to study the role of astrin depletion in inducing p53-dependent apoptosis and sensitizing HeLa cells to paclitaxel

Fri May 05 00:00:00 EDT 2006

Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells.

Mutation research

Chakraborty S,Ghosh U,Bhattacharyya NP,Bhattacharya RK,Roy M

MA5-13994 was used in western blot to study the effects of curcumin on telomerase activity and apoptosis in K-562 cells

Tue Apr 11 00:00:00 EDT 2006

Extent, relationship and prognostic significance of apoptosis and cell proliferation in synovial sarcoma.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

Sun B,Sun Y,Wang J,Zhao X,Wang X,Hao X

MA5-13994 was used in immunohistochemistry - paraffin section to examine apoptosis and cell proliferation in synovial sarcoma

Thu Jun 01 00:00:00 EDT 2006

Tea-induced apoptosis in human leukemia K562 cells as assessed by comet formation.

Asian Pacific journal of cancer prevention : APJCP

Chakraborty S,Kundu T,Dey S,Bhattacharya RK,Siddiqi M,Roy M

MA5-13994 was used in western blot to study tea-induced apoptosis in human leukemia K562 cells

Tue Sep 12 00:00:00 EDT 2006

Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin.

Cancer letters

Kundu T,Dey S,Roy M,Siddiqi M,Bhattacharya RK

MA5-13994 was used in western blot to study the mechanism of apoptosis induction in leukemic cells by the black tea polyphenol theaflavin

Thu Dec 08 00:00:00 EST 2005

Prognostic significance of Bax and Fas ligand in erionite and asbestos induced Turkish malignant pleural mesothelioma.

Lung cancer (Amsterdam, Netherlands)

Kokturk N,Firat P,Akay H,Kadilar C,Ozturk C,Zorlu F,Gungen Y,Emri S

MA5-13994 was used in immunohistochemistry to study the prognostic value of Fas ligand and Bax in Turkish malignant pleural mesothelioma

Tue Nov 01 00:00:00 EST 2005

Irreversible pan-ErbB tyrosine kinase inhibitor CI-1033 induces caspase-independent apoptosis in colorectal cancer DiFi cell line.

Apoptosis : an international journal on programmed cell death

Skvortsov S,Skvortsova I,Sarg B,Loeffler-Ragg J,Lindner H,Lukas P,Tabernero J,Zwierzina H

MA5-13994 was used in western blot to investigate the effect of pan-ErbB tyrosine kinase inhibitor CI-1033 on colorectal cancer cell apoptosis

Sat Oct 01 00:00:00 EDT 2005

Antibody selection in immunohistochemical detection of cyclin D1 in mantle cell lymphoma.

American journal of clinical pathology

Torlakovic E,Nielsen S,Vyberg M

MA5-13994 was used in immunohistochemistry to evaluate different antibodies in cyclin D1 detection in mantle cell lymphoma by immunohistochemistry

Tue Nov 01 00:00:00 EST 2005

Is the myofibrillarlytic myocyte a forme fruste apoptotic myocyte?

The Annals of thoracic surgery

Narula N,Narula J,Zhang PJ,Haider N,Raghunath PN,Brittin R,Gorman JH,Gorman RC,Tomaszewski JE

MA5-13994 was used in immunohistochemistry to study the presence and apoptotic status of myofibrillarlytic myocytes in ischemic cardiomyopathic hearts

Fri Apr 01 00:00:00 EST 2005

Simultaneous bilateral breast carcinomas: a category with frequent coexpression of HER-2 and ER-alpha, high Ki-67 and bcl-2, and low p53.

International journal of surgical pathology

Bassarova AV,Nesland JM,Sedloev T,Lilleby W,Hristova SL,Trifonov DY,Torlakovic E

MA5-13994 was used in immunohistochemistry to study the characteristics of simultaneous bilateral adenocarcinomas of the breast and their corresponding metastases

Fri Jul 01 00:00:00 EDT 2005

Downregulation of Bcl-2 by podocytes is associated with progressive glomerular injury and clinical indices of poor renal prognosis in human IgA nephropathy.

Journal of the American Society of Nephrology : JASN

Qiu LQ,Sinniah R,I-Hong Hsu S

MA5-13994 was used in immunohistochemistry to investigate the influence of Bcl-2 reduction on the progression and prognosis of human IgA nephropathy

Thu Jan 01 00:00:00 EST 2004

p73 expression is associated with the cellular radiosensitivity in cervical cancer after radiotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Liu SS,Leung RC,Chan KY,Chiu PM,Cheung AN,Tam KF,Ng TY,Wong LC,Ngan HY

MA5-13994 was used in immunohistochemistry to study the immunohistochemical expression of p73 in cervical cancer following radiotherapy and the association with radiosensistivity

Sat May 15 00:00:00 EDT 2004

Expression of Bcl-2 family members and presence of Epstein-Barr virus in the regulation of cell growth and death in classical Hodgkin's lymphoma.

Histopathology

Kim LH,Nadarajah VS,Peh SC,Poppema S

MA5-13994 was used in immunohistochemistry - paraffin section to assess the expression of the Bcl-2 family of proteins in classical Hodgkin's lymphoma and correlate their expression with proliferation, apoptosis, and the presence of Epstein-Barr virus

Mon Mar 01 00:00:00 EST 2004

Prognostic value of apoptosis in breast cancer (pT1-pT2). A TUNEL, p53, bcl-2, bag-1 and Bax immunohistochemical study.

Histology and histopathology

Sirvent JJ,Aguilar MC,Olona M,Pelegrí A,Blázquez S,Gutiérrez C

MA5-13994 was used in immunohistochemistry to study the prognostic value of apoptosis in breast carcinoma

Thu Jul 01 00:00:00 EDT 2004

Pilomatrix carcinoma with lymph node metastases.

Journal of cutaneous pathology

Bassarova A,Nesland JM,Sedloev T,Danielsen H,Christova S

MA5-13994 was used in immunohistochemistry to report on a case of pilomatrix carcinoma with lymph node metastases

Thu Apr 01 00:00:00 EST 2004

BCL-2 family proteins in peripheral T-cell lymphomas: correlation with tumour apoptosis and proliferation.

The Journal of pathology

Rassidakis GZ,Jones D,Lai R,Ramalingam P,Sarris AH,McDonnell TJ,Medeiros LJ

MA5-13994 was used in immunohistochemistry to investigate anti-apoptotic proteins in patients with peripheral T-cell lymphomas.

Sun Jun 01 00:00:00 EDT 2003

Differential expression of bcl-2 family proteins in bladder carcinomas. Relationship with apoptotic rate and survival.

European urology

Korkolopoulou P,Lazaris ACh,Konstantinidou AE,Kavantzas N,Patsouris E,Christodoulou P,Thomas-Tsagli E,Davaris P

MA5-13994 was used in immunohistochemistry to study the role of various bcl-2 family molecules in the regulation of apoptosis and the progression of urothelial cancer.

Fri Mar 01 00:00:00 EST 2002

The predictive value of bcl-2, bax, bcl-xL, bag-1, fas, and fasL for chemotherapy response in advanced breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Sjöström J,Blomqvist C,von Boguslawski K,Bengtsson NO,Mjaaland I,Malmström P,Ostenstadt B,Wist E,Valvere V,Takayama S,Reed JC,Saksela E

MA5-13994 was used in immunohistochemistry (paraffin) to assess fas and fasL as predictive indicators for chemotherapy response in advanced breast cancer.

Fri Mar 01 00:00:00 EST 2002

Differential Ki67 and bcl-2 immunoexpression in solid-glandular and spindle cell components of biphasic synovial sarcoma: a double immunostaining assessment with cytokeratin and vimentin.

Histopathology

Lopes JM,Nesland JM,Reis-Filho JS,Holm R

MA5-13994 was used in immunohistochemistry to study the expression of Ki67 and bcl-2 in solid-glandular and spindle cell components of biphasic synovial sarcoma

Wed May 01 00:00:00 EDT 2002

Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma.

FEBS letters

Gourdier I,Del Rio M,Crabbé L,Candeil L,Copois V,Ychou M,Auffray C,Martineau P,Mechti N,Pommier Y,Pau B

MA5-13994 was used in western blot to study the role of an apoptosis defect in acquired resistance to oxaliplatin in a cellular model of colon carcinoma

Wed Oct 09 00:00:00 EDT 2002

Reduced expression of both Bax and Bcl-2 is independently associated with lymph node metastasis in human breast carcinomas.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

Bukholm IR,Bukholm G,Nesland JM

MA5-13994 was used in immunohistochemistry to study the expression patterns of Bcl-2, Bcl-xL, and Bax protein in primary invasive breast carcinomas and the association with clinicopathological parameters

Fri Mar 01 00:00:00 EST 2002

Human Meissner corpuscles express Bcl-2 but not Bax protein.

Neuroscience letters

Ortiz-Rey JA,Alvarez-Alvarez C,Antón-Badiola I,San Miguel-Fraile P,De la Fuente-Buceta A

MA5-13994 was used in immunohistochemistry to investigate the expression of the bcl-2 and bax protein in human Meissner corpuscle

Fri Aug 30 00:00:00 EDT 2002

Escherichia coli induces apoptosis and proliferation of mammary cells.

Cell death and differentiation

Long E,Capuco AV,Wood DL,Sonstegard T,Tomita G,Paape MJ,Zhao X

MA5-13994 was used in Western Blot to study the effect of Escherichia col-induced mastitis on apoptosis and cell proliferation of mammary cells.

Wed Aug 01 00:00:00 EDT 2001

Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Ong F,Moonen LM,Gallee MP,ten Bosch C,Zerp SF,Hart AA,Bartelink H,Verheij M

MA5-13994 was used in immunohistochemistry to study the prognostic value of Bcl-2 and p53 in transitional cell cancer of the bladder

Thu Nov 01 00:00:00 EST 2001

Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax.

Journal of immunology (Baltimore, Md. : 1950)

Goetzl EJ,Kong Y,Mei B

MA5-13994 was used in western blot to report that LPA and S1P-mediated protection from apoptosis involves Edg GPCRs.

Mon Feb 15 00:00:00 EST 1999

Bioinformatics

Protein Aliases: Apoptosis regulator BAX; Bax zeta; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; Bcl-2-like protein 4; BCL2 associated X protein; BCL2-associated X protein omega; Bcl2-L-4

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Gene Aliases: BAX; BCL2L4

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UniProt ID: (Human) Q07812

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Entrez Gene ID: (Human) 581

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Function(s)

protein binding lipid binding channel activity heat shock protein binding protein complex binding identical protein binding protein homodimerization activity protein heterodimerization activity chaperone binding BH3 domain binding

Process(es)

Performance Guarantee

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Bax Monoclonal Antibody (2D2)

Bax Antibody (MA5-13994) in IHC (P)

Product Details

MA5-13994

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry - Free Floating (IHC (Free))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

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