Invitrogen

Bcl-10 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.

View all (69) BCL-10 antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-34800

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-

Immunoprecipitation (IP)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fragment corresponding to a region within amino acids 1 and 233 of BCL10 (Uniprot ID#O95999)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 1% BSA, 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2552152

Product Specific Information

Recommended positive controls: HeLa, Raji, Neuro2A, GL261, C8D30.

Predicted reactivity: Mouse (91%), Rat (92%), Pig (92%), Rhesus Monkey (99%), Bovine (95%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; RP11-234D19.2

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Gene Aliases: AI132454; BCL-10; BCL10; c-E10; C81403; CARMEN; cE10; CIPER; CLAP; IMD37; ME10

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UniProt ID: (Human) O95999, (Mouse) Q9Z0H7

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Entrez Gene ID: (Human) 8915, (Mouse) 12042

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Function(s)
protease binding transcription coactivator activity protein binding protein C-terminus binding transcription factor binding kinase activator activity enzyme binding kinase binding protein kinase binding ubiquitin protein ligase binding identical protein binding ubiquitin binding protein kinase B binding protein self-association NF-kappaB binding cysteine-type endopeptidase activator activity involved in apoptotic process protein homodimerization activity protein heterodimerization activity
Process(es)
B cell apoptotic process neural tube closure stimulatory C-type lectin receptor signaling pathway toll-like receptor signaling pathway response to molecule of bacterial origin adaptive immune response negative regulation of mature B cell apoptotic process cellular defense response I-kappaB kinase/NF-kappaB signaling cell death response to fungus immunoglobulin mediated immune response positive regulation of protein ubiquitination response to food positive regulation of mast cell cytokine production Fc-epsilon receptor signaling pathway lymphotoxin A biosynthetic process interleukin-6 biosynthetic process positive regulation of phosphorylation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process innate immune response positive regulation of interleukin-8 biosynthetic process positive regulation of transcription, DNA-templated T cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity protein oligomerization protein homooligomerization protein heterooligomerization T cell apoptotic process cellular response to mechanical stimulus positive regulation of extrinsic apoptotic signaling pathway immune system process apoptotic process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of JUN kinase activity regulation of apoptotic process positive regulation of apoptotic process fibroblast apoptotic process mast cell activation thymocyte apoptotic process positive regulation of execution phase of apoptosis
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