Invitrogen

Bcl-10 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

1 Reference
View all (69) BCL-10 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-85359

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Dog

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human BCL10.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2792501

Product Specific Information

Keep as concentrated solution.

Predicted reactivity: Mouse (95%), Rat (96%), Pig (96%), Rhesus Monkey (99%), Bovine (99%).

Positive Control: Jurkat, Neuro2A, GL261, C8D30.

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; R-RCD1; RCD; RP11-234D19.2

View more View less

Gene Aliases: AI132454; BCL-10; BCL10; c-E10; C81403; CARMEN; cE10; CIPER; CLAP; IMD37; ME10

View more View less

UniProt ID: (Human) O95999, (Rat) Q9QYN5, (Mouse) Q9Z0H7

View more View less

Entrez Gene ID: (Human) 8915, (Rat) 83477, (Mouse) 12042

View more View less

Function(s)
protease binding transcription coactivator activity protein binding protein C-terminus binding transcription factor binding kinase activator activity enzyme binding kinase binding protein kinase binding ubiquitin protein ligase binding identical protein binding ubiquitin binding protein kinase B binding protein self-association NF-kappaB binding cysteine-type endopeptidase activator activity involved in apoptotic process protein homodimerization activity protein heterodimerization activity
Process(es)
B cell apoptotic process neural tube closure response to molecule of bacterial origin adaptive immune response negative regulation of mature B cell apoptotic process apoptotic process cellular defense response I-kappaB kinase/NF-kappaB signaling cell death response to fungus immunoglobulin mediated immune response positive regulation of protein ubiquitination response to food positive regulation of phosphorylation positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process fibroblast apoptotic process innate immune response positive regulation of interleukin-8 biosynthetic process positive regulation of transcription, DNA-templated T cell receptor signaling pathway regulation of T cell receptor signaling pathway positive regulation of T cell activation positive regulation of NF-kappaB transcription factor activity protein oligomerization protein homooligomerization protein heterooligomerization T cell apoptotic process thymocyte apoptotic process cellular response to mechanical stimulus positive regulation of extrinsic apoptotic signaling pathway stimulatory C-type lectin receptor signaling pathway toll-like receptor signaling pathway positive regulation of mast cell cytokine production Fc-epsilon receptor signaling pathway lymphotoxin A biosynthetic process interleukin-6 biosynthetic process immune system process activation of cysteine-type endopeptidase activity involved in apoptotic process activation of JUN kinase activity regulation of apoptotic process mast cell activation positive regulation of execution phase of apoptosis
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support