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Product Details
MA5-14878
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
E.177.7
Immunogen
Synthetic peptide corresponding to residues surrounding Ser60 of Bcl10
Conjugate
Form
Liquid
Concentration
32 µg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_10980481
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
BCL-10 is an N-terminal CARD (Caspase Recruitment Domain) containing protein that is involved in the adaptive immune response. It promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL-10 is also an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is a substrate for MALT1. Mutations in the gene can lead to Immmunodeficiency 37 or Lymphoma, mucosa-associated lymphoid type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B-cell CLL/lymphoma 10; B-cell leukemia/lymphoma 10; B-cell lymphoma/leukemia 10; Bcl-10; c-E10; CARD containing molecule enhancing NF-kB; CARD-containing apoptotic signaling protein; CARD-containing molecule enhancing NF-kappa-B; CARD-containing proapoptotic protein; CARD-like apoptotic protein; caspase-recruiting domain-containing protein; cCARMEN; CED-3/ICH-1 prodomain homologous E10-like regulator; Cellular homolog of vCARMEN; Cellular-E10; CIPER; hCLAP; Mamm; Mammalian CARD-containing adapter molecule E10; mCIPER; mCLAP; mE10; OTTHUMP00000011647; OTTHUMP00000036080; R-RCD1; RCD; RP11-234D19.2
Gene Aliases: AI132454; BCL-10; BCL10; c-E10; C81403; CARMEN; cE10; CIPER; CLAP; IMD37; ME10
UniProt ID: (Human) O95999, (Rat) Q9QYN5, (Mouse) Q9Z0H7
Entrez Gene ID: (Human) 8915, (Rat) 83477, (Mouse) 12042
protease binding
transcription coactivator activity
protein binding
protein C-terminus binding
transcription factor binding
kinase activator activity
enzyme binding
kinase binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
ubiquitin binding
protein kinase B binding
protein self-association
NF-kappaB binding
cysteine-type endopeptidase activator activity involved in apoptotic process
protein homodimerization activity
protein heterodimerization activity
B cell apoptotic process
neural tube closure
response to molecule of bacterial origin
adaptive immune response
negative regulation of mature B cell apoptotic process
apoptotic process
cellular defense response
I-kappaB kinase/NF-kappaB signaling
cell death
response to fungus
immunoglobulin mediated immune response
positive regulation of protein ubiquitination
response to food
positive regulation of phosphorylation
positive regulation of apoptotic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
fibroblast apoptotic process
innate immune response
positive regulation of interleukin-8 biosynthetic process
positive regulation of transcription, DNA-templated
T cell receptor signaling pathway
regulation of T cell receptor signaling pathway
positive regulation of T cell activation
positive regulation of NF-kappaB transcription factor activity
protein oligomerization
protein homooligomerization
protein heterooligomerization
T cell apoptotic process
thymocyte apoptotic process
cellular response to mechanical stimulus
positive regulation of extrinsic apoptotic signaling pathway
stimulatory C-type lectin receptor signaling pathway
toll-like receptor signaling pathway
positive regulation of mast cell cytokine production
Fc-epsilon receptor signaling pathway
lymphotoxin A biosynthetic process
interleukin-6 biosynthetic process
immune system process
activation of cysteine-type endopeptidase activity involved in apoptotic process
activation of JUN kinase activity
regulation of apoptotic process
mast cell activation
positive regulation of execution phase of apoptosis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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