Proteintech

Bcl-XL Polyclonal Antibody

Bcl-XL Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

Bcl-XL Antibody (26967-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol) fixed HepG2 cells using 26967-1-AP (Bcl-XL antibody) at dilution of 1:50 and Alexa Fluor 488-Conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Bcl-XL Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Bcl-XL Antibody in Flow Cytometry (Flow)

Bcl-XL Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

26967-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 59 publications 59 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-dependent

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Bcl-XL Fusion Protein Ag25604 (1-128 aa encoded by BC019307)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.43 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody can recognize Bcl-XL, Bcl-XS and Bcl-X (Beta).

Immunogen sequence: MSQSNRELV VDFLSYKLSQ KGYSWSQFSD VEENRTEAPE GTESEMETPS AINGNPSWHL ADSPAVNGAT GHSSSLDARE VIPMAAVKQA LREAGDEFEL RYRRAFSDLT SQLHITPGTA YQSFEQVVN (1-128 aa encoded by BC019307 )

Target Information

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Mcl-1 stabilization confers resistance to taxol in human gastric cancer.

Oncotarget

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Mcl-1 stabilization confers resistance to taxol in human gastric cancer.

Oncotarget

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Role of the lncRNA ABHD11-AS₁ in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC.

Molecular cancer

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Thu Aug 17 00:00:00 EDT 2017

Role of the lncRNA ABHD11-AS₁ in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC.

Molecular cancer

Wu DD,Chen X,Sun KX,Wang LL,Chen S,Zhao Y

Thu Aug 17 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: anti-apoptosis regulatory protein; Apoptosis regulator Bcl-X; B-cell leukemia/lymphoma x; Bcl-2-like protein 1; bcl-xS; Bcl2-L-1; BCL2-like 1; BCLXL; BCLXS; DKFZp781P2092; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3

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Gene Aliases: Bcl(X)L; Bcl-X; Bcl-XL; BCL-XL/S; bcl2-L-1; BCL2L; BCL2L1; BCLX; PPP1R52

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UniProt ID: (Human) Q07817, (Mouse) Q64373

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Entrez Gene ID: (Human) 598, (Mouse) 12048

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Function(s)

protein binding protein kinase binding identical protein binding protein homodimerization activity protein heterodimerization activity BH3 domain binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process BH domain binding MDM2/MDM4 family protein binding

Process(es)

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Bcl-XL Polyclonal Antibody

Bcl-XL Antibody (26967-1-AP) in ICC/IF

Product Details

26967-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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