Proteintech

Beclin 1 Monoclonal Antibody (1C10C4)

Beclin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 8

Beclin 1 Antibody (66665-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human stomach tissue slide using 66665-1-Ig (Beclin 1 antibody) at dilution of 1:500 (under 40x lens).

Beclin 1 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

Product Details

66665-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:2,000-1:10,000

View 43 publications 43 publications

Immunohistochemistry (IHC)

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:1,000

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:50-1:500

View 9 publications 9 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

1C10C4

Immunogen

Beclin 1 Fusion Protein Ag1843 (141-450 aa encoded by BC010276)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TDTLLDQLD TQLNVTENEC QNYKRCLEIL EQMNEDDSEQ LQMELKELAL EEERLIQELE DVEKNRKIVA ENLEKVQAEA ERLDQEEAQY QREYSEFKRQ QLELDDELKS VENQMRYAQT QLDKLKKTNV FNATFHIWHS GQFGTINNFR LGRLPSVPVE WNEINAAWGQ TVLLLHALAN KMGLKFQRYR LVPYGNHSYL ESLTDKSKEL PLYCSGGLRF FWDNKFDHAM VAFLDCVQQF KEEVEKGETR FCLPYRMDVE KGKIEDTGGS GGSYSIKTQF NSEEQWTKAL KFMLTNLKWG LAWVSSQFYN K (141-450 aa encoded by BC010276)

Target Information

Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e

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Gene Aliases: 4921513J16Rik; 5430417M23Rik; ATG6; beclin1; BECN1; GT197; VPS30

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UniProt ID: (Human) Q14457, (Rat) Q91XJ1, (Mouse) O88597

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Entrez Gene ID: (Human) 8678, (Rat) 114558, (Mouse) 56208

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Function(s)

protein binding ubiquitin protein ligase binding phosphatidylinositol 3-kinase binding molecular_function protease inhibitor

Process(es)

autophagosome assembly cytokinesis response to hypoxia autophagy apoptotic process cellular defense response cellular response to nitrogen starvation lysosome organization mitotic metaphase plate congression negative regulation of cell proliferation positive regulation of autophagy positive regulation of phosphatidylinositol 3-kinase signaling macroautophagy positive regulation of macroautophagy CVT pathway regulation of cytokinesis receptor catabolic process response to vitamin E cellular response to glucose starvation response to drug negative regulation of apoptotic process engulfment of apoptotic cell nucleophagy late endosome to vacuole transport neuron development beta-amyloid metabolic process regulation of catalytic activity defense response to virus negative regulation of cell death cellular response to aluminum ion cellular response to epidermal growth factor stimulus mitophagy in response to mitochondrial depolarization positive regulation of attachment of mitotic spindle microtubules to kinetochore positive regulation of mitophagy negative regulation of reactive oxygen species metabolic process mitophagy response to other organism angiogenesis cell cycle cell division

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Beclin 1 Monoclonal Antibody (1C10C4)

Beclin 1 Antibody (66665-1-IG) in IHC (P)

Product Details

66665-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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