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Invitrogen
Beclin 1 Recombinant Rabbit Monoclonal Antibody (9D8K9)
FIGURE: 1 / 4
Beclin 1 Antibody (MA5-51201) in ICC/IF
Immunocytochemistry (confocal imaging) analysis of HeLa cells usingBeclin1Recombinant monoclonal antibody (Product # MA5-51201) using a dilution of 1:100 (Red). The cells were counterstained with Vimentin Rabbit mAb (Product # MA5-35320) using a dilution of 1:100 (Green). DAPI was used for nuclear staining (blue). Objective: 60x.
Product Details
MA5-51201
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9D8K9
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human Beclin 1 (NP_003757.1).
Conjugate
Form
Liquid
Concentration
1.2 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_3094195
Product Specific Information
Immunogen sequence: MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG
Target Information
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e
Gene Aliases: 4921513J16Rik; 5430417M23Rik; ATG6; beclin1; BECN1; GT197; VPS30
UniProt ID: (Human) Q14457, (Rat) Q91XJ1, (Mouse) O88597
Entrez Gene ID: (Human) 8678, (Rat) 114558, (Mouse) 56208
autophagosome assembly
cytokinesis
response to hypoxia
autophagy
apoptotic process
cellular defense response
cellular response to nitrogen starvation
lysosome organization
mitotic metaphase plate congression
negative regulation of cell proliferation
positive regulation of autophagy
positive regulation of phosphatidylinositol 3-kinase signaling
macroautophagy
positive regulation of macroautophagy
CVT pathway
regulation of cytokinesis
receptor catabolic process
response to vitamin E
cellular response to glucose starvation
response to drug
negative regulation of apoptotic process
engulfment of apoptotic cell
nucleophagy
late endosome to vacuole transport
neuron development
beta-amyloid metabolic process
regulation of catalytic activity
defense response to virus
negative regulation of cell death
cellular response to aluminum ion
cellular response to epidermal growth factor stimulus
mitophagy in response to mitochondrial depolarization
positive regulation of attachment of mitotic spindle microtubules to kinetochore
positive regulation of mitophagy
negative regulation of reactive oxygen species metabolic process
mitophagy
response to other organism
angiogenesis
cell cycle
cell division
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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