Alomone Labs, LTD

Beta 1 Na+/K+ ATPase (extracellular) Polyclonal Antibody

View all (10) ATP1B1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ANP-014-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide CKAYGENIGYSEKDR, corresponding to amino acid residues 277-291 of mouse ATP1B1, Extracellular, C-terminus
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenosinetriphosphatase; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; MGC1798; Na+/K+ ATPase Beta; Na, K-ATPase beta-1 polypeptide; Na,K-ATPase beta 1 subunit; OTTHUMP00000032537; OTTHUMP00000032538; Sodium Potassium ATPase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1

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Gene Aliases: ATP1B; ATP1B1; Atp4b; Atpb; Atpb-1; ATPBS; NKbeta1

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UniProt ID: (Human) Q5TGZ3, (Rat) P07340, (Mouse) P14094

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Entrez Gene ID: (Human) 481, (Rat) 25650, (Mouse) 11931

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Function(s)
ATPase activator activity sodium:potassium-exchanging ATPase activity protein binding ATP binding protein C-terminus binding drug binding ATPase activity MHC class II protein complex binding potassium ion binding sodium ion binding ATPase binding primary active transporter
Process(es)
response to hypoxia positive regulation of defense response to virus by host cellular calcium ion homeostasis cellular sodium ion homeostasis cell adhesion potassium ion import establishment or maintenance of transmembrane electrochemical gradient regulation of gene expression regulation of cardiac muscle contraction by calcium ion signaling cellular potassium ion homeostasis positive regulation of ATPase activity ion transmembrane transport sodium ion export from cell protein transport into plasma membrane raft ATP metabolic process protein stabilization leukocyte migration relaxation of cardiac muscle cardiac muscle contraction protein localization to plasma membrane membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction ATP hydrolysis coupled transmembrane transport mitophagy in response to mitochondrial depolarization xenophagy positive regulation of potassium ion transmembrane transporter activity positive regulation of sodium ion export from cell positive regulation of calcium:sodium antiporter activity positive regulation of potassium ion import regulation of cardiac conduction potassium ion import across plasma membrane blastocyst development potassium ion transport sodium ion transport metal ion transport regulation of calcium ion transmembrane transport transport ion transport
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