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Product Details
28393-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: CLQYDDQKIV SGLRDNTIKI WDKNTLECKR ILTGHTGSVL CLQYDERVII TGSSDSTVRV WDVNTGEMLN TLIHHCEAVL HLRFNNGMMV TCSKDRSIAV WDMASPTDIT LRRVLVGHRA AVNVVDFDDK YIVSASGDRT IKVWNTSTCE FVRTLNGHKR GIACLQYRDR LVVSGSSDNT IRLWDIECGA CLRVLEGHEE LVRCIRFDNK RIVSGAYDGK IKVWDLVAAL DPRAPAGTLC LRTLVEHSGR VFRLQFDEFQ IVSSSHDDTI LIWDFLNDPA AQAEPPRSPS RTYTYISR
Target Information
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: beta-transducin repeat containing protein; Beta-transducin repeat-containing protein; Beta-TrCP; Beta-TrCP protein E3RS-IkappaB; beta-TrCP1; btrc; E3RSIkappaB; Epididymis tissue protein Li 2a; F-box and WD repeats protein beta-TrCP; F-box and WD-repeat protein 1B; F-box/WD repeat-containing protein 1A; HOS; mE3RS-IkappaB; pIkappaB-E3 receptor subunit; pIkappaBalpha-E3 receptor subunit; SCF b-TRCP; Ubiquitin ligase FWD1
Gene Aliases: b-TrCP; BETA-TRCP; Beta-Trcp1; betaTrCP; BTRC; BTRCP; bTrCP1; E3RS-IkappaB; E3RSIkappaB; Fbw1; FBW1A; FBXW1; FBXW1A; FWD1; HOS; Kiaa4123; Slimb
UniProt ID: (Human) Q9Y297, (Mouse) Q3ULA2
Entrez Gene ID: (Human) 8945, (Mouse) 12234, (Rat) 361765
G2/M transition of mitotic cell cycle
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
protein dephosphorylation
ubiquitin-dependent protein catabolic process
signal transduction
viral process
Wnt signaling pathway
protein ubiquitination
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
protein destabilization
mammary gland epithelial cell proliferation
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
regulation of circadian rhythm
positive regulation of circadian rhythm
regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of proteolysis
negative regulation of smoothened signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
rhythmic process
T cell receptor signaling pathway
stress-activated MAPK cascade
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
branching involved in mammary gland duct morphogenesis
regulation of canonical Wnt signaling pathway
regulation of proteasomal protein catabolic process
cellular response to organic cyclic compound
protein catabolic process
regulation of cell cycle
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