Product References
DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kurani H,Razavipour SF,Harikumar KB,Dunworth M,Ewald AJ,Nasir A,Pearson G,Van Booven D,Zhou Z,Azzam D,Wahlestedt C,Slingerland J
11-5071-42 was used in Flow Cytometry to study the effect of DOTL1 inhibition on cancer stem cells.
Mon May 02 00:00:00 EDT 2022
DOT1L Is a Novel Cancer Stem Cell Target for Triple-Negative Breast Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Kurani H,Razavipour SF,Harikumar KB,Dunworth M,Ewald AJ,Nasir A,Pearson G,Van Booven D,Zhou Z,Azzam D,Wahlestedt C,Slingerland J
11-5071-42 was used in Flow Cytometry to study the effect of DOTL1 inhibition on cancer stem cells.
Mon May 02 00:00:00 EDT 2022
ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export.
EMBO reports
Malla S,Prasad Bhattarai D,Groza P,Melguizo-Sanchis D,Atanasoai I,Martinez-Gamero C,Román ÁC,Zhu D,Lee DF,Kutter C,Aguilo F
11-5071-42 was used in Flow Cytometry to expand the role of ZFP207 in maintaining ESC identity, and underscore the functional versatility of ZFP207 in regulating neural fate commitment.
Thu Feb 03 00:00:00 EST 2022
Tyro3 Targeting as a Radiosensitizing Strategy in Bladder Cancer through Cell Cycle Dysregulation.
International journal of molecular sciences
Silina L,Dufour F,Rapinat A,Reyes C,Gentien D,Maksut F,Radvanyi F,Verrelle P,Bernard-Pierrot I,Mégnin-Chanet F
11-5071-42 was used in Flow cytometry/Cell sorting to find that TYRO3 expression impacts the radiation response via the cell cycle dysregulation with noeffets on the DNA repair.
Thu Aug 04 00:00:00 EDT 2022
WASH interacts with Ku to regulate DNA double-stranded break repair.
iScience
Wang T,Du XH,Hong Y,Hong X,Fan L,Zhou JW,Sun H,Ge J,Billadeau DD,Deng ZH
11-5071-42 was used in Flow Cytometry to show that Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) interacts with core non-homologous end-joining factors including Ku70/Ku80 and DNA-PKcs, and Ku70/Ku80 is involved in the recruitment of WASH to the sites of DNA double-stranded break.
Fri Jan 21 00:00:00 EST 2022
Autoreactive CD8+ T cells are restrained by an exhaustion-like program that is maintained by LAG3.
Nature immunology
Grebinoski S,Zhang Q,Cillo AR,Manne S,Xiao H,Brunazzi EA,Tabib T,Cardello C,Lian CG,Murphy GF,Lafyatis R,Wherry EJ,Das J,Workman CJ,Vignali DAA
11-5071-42 was used in Flow cytometry/Cell sorting to show that intra-islet CD8+ T cells phenotypically, transcriptionally, epigenetically and metabolically possess features of canonically exhausted T cells, yet maintain important differences.
Wed Jun 01 00:00:00 EDT 2022
Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma.
Translational oncology
Yu VZ,So SS,Lung ML
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
MicroRNA-567 inhibits cell proliferation and induces cell apoptosis in A549 NSCLC cells by regulating cyclin-dependent kinase 8.
Saudi journal of biological sciences
Elkady MA,Doghish AS,Elshafei A,Elshafey MM
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Immunocytochemistry
Thu Apr 01 00:00:00 EDT 2021
BCOR Internal Tandem Duplication Expression in Neural Stem Cells Promotes Growth, Invasion, and Expression of PRC2 Targets.
International journal of molecular sciences
Nakata S,Yuan M,Rubens JA,Kahlert UD,Maciaczyk J,Raabe EH,Eberhart CG
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Sat Apr 10 00:00:00 EDT 2021
Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo.
Nature chemical biology
Dubiella C,Pinch BJ,Koikawa K,Zaidman D,Poon E,Manz TD,Nabet B,He S,Resnick E,Rogel A,Langer EM,Daniel CJ,Seo HS,Chen Y,Adelmant G,Sharifzadeh S,Ficarro SB,Jamin Y,Martins da Costa B,Zimmerman MW,Lian X,Kibe S,Kozono S,Doctor ZM,Browne CM,Yang A,Stoler-Barak L,Shah RB,Vangos NE,Geffken EA,Oren R,Koide E,Sidi S,Shulman Z,Wang C,Marto JA,Dhe-Paganon S,Look T,Zhou XZ,Lu KP,Sears RC,Chesler L,Gray NS,London N
11-5071-42 was used in Flow cytometry/Cell sorting to demonstrate that Sulfopin is a chemical probe suitable for assessment of Pin1-dependent pharmacology in cells and in vivo.
Wed Sep 01 00:00:00 EDT 2021
Detecting chromatin interactions between and along sister chromatids with SisterC.
Nature methods
Oomen ME,Hedger AK,Watts JK,Dekker J
11-5071 was used in Flow cytometry/Cell sorting to describe SisterC, a chromosome conformation capture assay that distinguishes interactions between and along identical sister chromatids.
Thu Oct 01 00:00:00 EDT 2020
Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration.
Cell research
Zhou S,Zhang W,Cai G,Ding Y,Wei C,Li S,Yang Y,Qin J,Liu D,Zhang H,Shao X,Wang J,Wang H,Yang W,Wang H,Chen S,Hu P,Sun L
11-5071 was used in Flow cytometry/Cell sorting to indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration.
Tue Dec 01 00:00:00 EST 2020
The transcription factor Hhex cooperates with the corepressor Tle3 to promote memory B cell development.
Nature immunology
Laidlaw BJ,Duan L,Xu Y,Vazquez SE,Cyster JG
11-5071 was used in Flow cytometry/Cell sorting to identify a population of germinal center (GC) B cells in the process of differentiating into memory B cells.
Tue Sep 01 00:00:00 EDT 2020
A Mechanism for microRNA Arm Switching Regulated by Uridylation.
Molecular cell
Kim H,Kim J,Yu S,Lee YY,Park J,Choi RJ,Yoon SJ,Kang SG,Kim VN
11-5071-42 was used in Flow Cytometry to uncover a role of uridylation as a molecular switch in alternative strand selection and thus implicating its therapeutic potential.
Thu Jun 18 00:00:00 EDT 2020
A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage.
Journal of cell science
Lupieri A,Blaise R,Ghigo A,Smirnova N,Sarthou MK,Malet N,Limon I,Vincent P,Hirsch E,Gayral S,Ramel D,Laffargue M
11-5071 was used in Immunocytochemistry-Immunofluorescence to provide evidence for a kinase-independent role of PI3Kγ in arterial remodeling and reveal novel strategies targeting the docking function of PI3Kγ for the treatment of cardiovascular diseases.
Thu Jul 09 00:00:00 EDT 2020
ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells.
Cell death & disease
Constantin D,Widmann C
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Mon Nov 30 00:00:00 EST 2020
ASH2L drives proliferation and sensitivity to bleomycin and other genotoxins in Hodgkin's lymphoma and testicular cancer cells.
Cell death & disease
Constantin D,Widmann C
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Mon Nov 30 00:00:00 EST 2020
Sphingosine-1-phosphate receptor 2 restrains egress of γδ T cells from the skin.
The Journal of experimental medicine
Laidlaw BJ,Gray EE,Zhang Y,Ramírez-Valle F,Cyster JG
11-5071-42 was used in Flow Cytometry to provide a mechanism for how IL-17+ γδ T cells establish residence within the dermis and identify a role for S1PR2 in restraining the egress of tissue-resident lymphocytes.
Mon Jul 01 00:00:00 EDT 2019
Abemaciclib Is Effective Against Pancreatic Cancer Cells and Synergizes with HuR and YAP1 Inhibition.
Molecular cancer research : MCR
Dhir T,Schultz CW,Jain A,Brown SZ,Haber A,Goetz A,Xi C,Su GH,Xu L,Posey J,Jiang W,Yeo CJ,Golan T,Pishvaian MJ,Brody JR
11-5071 was used in Flow cytometry/Cell sorting to evaluate the efficacy of abemaciclib in pre-clinical pancreatic ductal adenocarcinomas (PDAC) models in vitro and in vivo and explore its mechanism of action, and screened for potential synergistic combinations.
Tue Oct 01 00:00:00 EDT 2019
Functional Heterogeneity of Mouse Prostate Stromal Cells Revealed by Single-Cell RNA-Seq.
iScience
Kwon OJ,Zhang Y,Li Y,Wei X,Zhang L,Chen R,Creighton CJ,Xin L
11-5071 was used in Flow cytometry/Cell sorting to characterise mouse Prostate stromal cells heterogeneity by single-cell RNA-seq.
Fri Mar 29 00:00:00 EDT 2019
The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62.
Science advances
Xu D,Li X,Shao F,Lv G,Lv H,Lee JH,Qian X,Wang Z,Xia Y,Du L,Zheng Y,Wang H,Lyu J,Lu Z
11-5071 was used in Flow cytometry/Cell sorting to demonstrate that under oxidative stress, hepatocellular carcinoma (HCC) cells exhibit increased antioxidative response and survival rates compared to normal hepatocytes.
Mon Apr 01 00:00:00 EDT 2019
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
11-5071 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
Mapping macrophage polarization over the myocardial infarction time continuum.
Basic research in cardiology
Mouton AJ,DeLeon-Pennell KY,Rivera Gonzalez OJ,Flynn ER,Freeman TC,Saucerman JJ,Garrett MR,Ma Y,Harmancey R,Lindsey ML
11-5071 was used in ICC/IF to examine macrophage polarisation over the myocardial infarction time continuum.
Mon Jun 04 00:00:00 EDT 2018
Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer.
International journal of oncology
Kang MA,Kim W,Jo HR,Shin YJ,Kim MH,Jeong JH
11-5071 was used in Flow cytometry/Cell sorting to indicate that the utilization of AT7519 and SNS-032 as part of an adjuvant treatment may help control cervical cancer progression.
Wed Aug 01 00:00:00 EDT 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice.
Nature communications
Grinenko T,Eugster A,Thielecke L,Ramasz B,Krüger A,Dietz S,Glauche I,Gerbaulet A,von Bonin M,Basak O,Clevers H,Chavakis T,Wielockx B
11-5071 was used in Flow cytometry/Cell sorting to study the mechanisms that control fate decision in adult haematopoietic stem cells.s.
Tue May 15 00:00:00 EDT 2018
FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging.
The Journal of clinical investigation
Li H,Liu P,Xu S,Li Y,Dekker JD,Li B,Fan Y,Zhang Z,Hong Y,Yang G,Tang T,Ren Y,Tucker HO,Yao Z,Guo X
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Mon Apr 03 00:00:00 EDT 2017
PKN2 is essential for mouse embryonic development and proliferation of mouse fibroblasts.
Genes to cells : devoted to molecular & cellular mechanisms
Danno S,Kubouchi K,Mehruba M,Abe M,Natsume R,Sakimura K,Eguchi S,Oka M,Hirashima M,Yasuda H,Mukai H
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice.
Nature communications
Liu X,Shao Z,Jiang W,Lee BJ,Zha S
11-5071 was used in Flow cytometry/Cell sorting to identify the functions of PAXX in KU accumulation at DNA ends and reveal critically complementary functions of PAXX and XLF during non-homologous end-joining.
Wed Jan 04 00:00:00 EST 2017
MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression.
Nature communications
Teng Y,Ren Y,Hu X,Mu J,Samykutty A,Zhuang X,Deng Z,Kumar A,Zhang L,Merchant ML,Yan J,Miller DM,Zhang HG
11-5071 was used in Flow cytometry/Cell sorting to examine exosomal miRNA expression profiles in various cancer tissues.
Fri Feb 17 00:00:00 EST 2017
Temporal neutrophil polarization following myocardial infarction.
Cardiovascular research
Ma Y,Yabluchanskiy A,Iyer RP,Cannon PL,Flynn ER,Jung M,Henry J,Cates CA,Deleon-Pennell KY,Lindsey ML
Sun May 01 00:00:00 EDT 2016
ATRX binds to atypical chromatin domains at the 3' exons of zinc finger genes to preserve H3K9me3 enrichment.
Epigenetics
Valle-García D,Qadeer ZA,McHugh DS,Ghiraldini FG,Chowdhury AH,Hasson D,Dyer MA,Recillas-Targa F,Bernstein E
11-5071 was used in Flow cytometry/Cell sorting to investigate ATRX targets in human cell lines.
Thu Jun 02 00:00:00 EDT 2016
Annexin A1 contributes to pancreatic cancer cell phenotype, behaviour and metastatic potential independently of Formyl Peptide Receptor pathway.
Scientific reports
Belvedere R,Bizzarro V,Forte G,Dal Piaz F,Parente L,Petrella A
11-5071 was used in Flow cytometry/Cell sorting to investigate mechanisms by which intracellular ANXA1 could mediate pancreatic cancer progression.
Thu Jul 14 00:00:00 EDT 2016
Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis.
Nature cell biology
Fong MY,Zhou W,Liu L,Alontaga AY,Chandra M,Ashby J,Chow A,O'Connor ST,Li S,Chin AR,Somlo G,Palomares M,Li Z,Tremblay JR,Tsuyada A,Sun G,Reid MA,Wu X,Swiderski P,Ren X,Shi Y,Kong M,Zhong W,Chen Y,Wang SE
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Sun Feb 01 00:00:00 EST 2015
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.
eLife
Hettmer S,Schinzel AC,Tchessalova D,Schneider M,Parker CL,Bronson RT,Richards NG,Hahn WC,Wagers AJ
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Sat Oct 24 00:00:00 EDT 2015
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma.
eLife
Hettmer S,Schinzel AC,Tchessalova D,Schneider M,Parker CL,Bronson RT,Richards NG,Hahn WC,Wagers AJ
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Sat Oct 24 00:00:00 EDT 2015
Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Reynolds AE,Kuraoka M,Kelsoe G
11-5071 was used in Flow cytometry/Cell sorting to investigate the origin of natural IgM, showing that it is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Thu Jan 01 00:00:00 EST 2015
NK-cells are involved in thymic atrophy induced by influenza A virus infection.
The Journal of general virology
Duan X,Lu J,Zhou K,Wang J,Wu J,Fu Gao G,Fang M
11-5071 was used in Flow cytometry/Cell sorting to demonstrate that influenza A virus infection in mice led to severe thymic atrophy caused by increased thymic T-cell apoptosis and suppressed proliferation.
Sun Nov 01 00:00:00 EDT 2015
CENP-32 is required to maintain centrosomal dominance in bipolar spindle assembly.
Molecular biology of the cell
Ohta S,Wood L,Toramoto I,Yagyu K,Fukagawa T,Earnshaw WC
11-5071 was used in Flow cytometry/Cell sorting to suggest that CENP32 is required for centrosomes to integrate into a fully functional spindle.
Wed Apr 01 00:00:00 EDT 2015
Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium.
The Journal of clinical investigation
Moding EJ,Lee CL,Castle KD,Oh P,Mao L,Zha S,Min HD,Ma Y,Das S,Kirsch DG
11-5071 was used in Flow cytometry/Cell sorting to determine that endothelial cells must progress through the cell cycle in order to be radiosensitized by Atm deletion.
Fri Aug 01 00:00:00 EDT 2014
The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.
Journal of immunology (Baltimore, Md. : 1950)
Ni PP,Solomon B,Hsieh CS,Allen PM,Morris GP
11-5071 was used in Flow cytometry/Cell sorting to investigate how dual TCR rearrangements enhance positive selection and alter allo- and autoreactive T cell repertoires.
Fri Aug 15 00:00:00 EDT 2014
Impaired B cell inhibition by lupus bone marrow mesenchymal stem cells is caused by reduced CCL2 expression.
Journal of immunology (Baltimore, Md. : 1950)
Che N,Li X,Zhang L,Liu R,Chen H,Gao X,Shi S,Chen W,Sun L
11-5071 was used in Flow cytometry/Cell sorting to investigate whether mesenchymal stem cells from lupus-like mice and patients with systemic lupus erythematosus exhibit the same immunoregulatory activity as normal MSC for B cell inhibition.
Sat Nov 15 00:00:00 EST 2014
Interleukin-7 expression and its effect on natural killer cells in patients with multiple sclerosis.
Journal of neuroimmunology
Su N,Shi SX,Zhu X,Borazanci A,Shi FD,Gan Y
Published figure using BrdU monoclonal antibody (Product # 11-5071-42) in Flow Cytometry
Sat Nov 15 00:00:00 EST 2014
MiR-630 inhibits proliferation by targeting CDC7 kinase, but maintains the apoptotic balance by targeting multiple modulators in human lung cancer A549 cells.
Cell death & disease
Cao JX,Lu Y,Qi JJ,An GS,Mao ZB,Jia HT,Li SY,Ni JH
11-5071 was used in Flow cytometry/Cell sorting to assess the relationships between expression of miR-630 and various cell surface markers in a number of cancer cell lines.
Thu Sep 25 00:00:00 EDT 2014
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment.
Journal for immunotherapy of cancer
Spranger S,Koblish HK,Horton B,Scherle PA,Newton R,Gajewski TF
11-5071 was used in Flow cytometry/Cell sorting to assess the effectiveness of different immunotherapy combination treatments against the murine B16.SIY melanoma model.
Thu May 15 00:00:00 EDT 2014
Functional analysis of prognostic gene expression network genes in metastatic breast cancer models.
PloS one
Geiger TR,Ha NH,Faraji F,Michael HT,Rodriguez L,Walker RC,Green JE,Simpson RM,Hunter KW
11-5071 was used in Flow cytometry/Cell sorting to investigate the co-expression network approach for the identification of metastasis-associated genes in breast cancer models.
Thu Dec 24 00:00:00 EST 2015
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Nature immunology
Gracias DT,Stelekati E,Hope JL,Boesteanu AC,Doering TA,Norton J,Mueller YM,Fraietta JA,Wherry EJ,Turner M,Katsikis PD
11-5071 was used in Flow cytometry/Cell sorting to study the role of miR-155 in the regulation of CD8(+) T cell interferon responses to pathogens in vivo.
Sat Jun 01 00:00:00 EDT 2013
The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells.
Cell cycle (Georgetown, Tex.)
Kullmann MK,Grubbauer C,Goetsch K,Jäkel H,Podmirseg SR,Trockenbacher A,Ploner C,Cato AC,Weiss C,Kofler R,Hengst L
11-5071 was used in Flow cytometry/Cell sorting to investigate the effect of dexamethasone on T-lymphoma cells.
Thu Aug 15 00:00:00 EDT 2013
STAT3 positively regulates an early step in B-cell development.
Blood
Chou WC,Levy DE,Lee CK
11-5071 was used in Flow cytometry/Cell sorting to study the transcription factors required for B lymphocyte development from progenitors in the bone marrow, showing that STAT3 positively regulates an early step in B-cell development.
Wed Nov 01 00:00:00 EST 2006
