Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Peptide sequence: HCVHKFHSLP KSGEKPEADR NPPVLYHNSR ARSTGACNCG RKQAPRDDPF
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Amplified in breast cancer gene 2 protein; FLJ10587; FLJ23205; Nonsense-mediated mRNA decay factor SMG8; Protein smg-8 homolog; smg-8 homolog, nonsense mediated mRNA decay factor; SMG8 nonsense mediated mRNA decay factor
Gene Aliases: ABC2; C17orf71; SMG8
UniProt ID: (Human) Q8ND04
Entrez Gene ID: (Human) 55181
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