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Product Details
MA1-70060
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
8D6
Immunogen
RBL-2H3 (rat basophilic leukemia) transfected cells expressing human C5aR on the cell surface.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1073841
Product Specific Information
MA1-70060 detects C5a receptor in human samples.
MA1-70060 has been successfully used in flow cytometry and immunohistochemistry (frozen sections) procedures.
The MA1-70060 immunogen is RBL-2H3 (rat basophilic leukemia) transfected cells expressing human C5aR on the cell surface.
Target Information
CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5a-R; CD88; CD88 antigen; complement component 5 receptor 1
Gene Aliases: C5A; C5AR; C5AR1; C5R1; CD88
UniProt ID: (Human) P21730
Entrez Gene ID: (Human) 728
activation of MAPK activity
apoptotic process
chemotaxis
inflammatory response
immune response
cellular defense response
signal transduction
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
sensory perception of chemical stimulus
positive regulation of vascular endothelial growth factor production
positive regulation of macrophage chemotaxis
cell proliferation in hindbrain
regulation of complement activation
neutrophil chemotaxis
organ regeneration
response to peptidoglycan
response to lipopolysaccharide
complement component C5a signaling pathway
mRNA transcription from RNA polymerase II promoter
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
positive regulation of epithelial cell proliferation
defense response to Gram-positive bacterium
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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