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C5AR1 Antibody (MA5-28092) in Flow
Flow cytometry of C5AR1 in red cell lysed human blood. Sample was incubated in the presence of human Seroblock, C5AR1 monoclonal antibody (Product # MA5-28092) and gated on granulocytes. Figures are arranged as follows: A) Alexa Fluor647 conjugated mouse anti human CD16 and RPE conjugated mouse IgG2a isotype control. B) Alexa Fluor647 conjugated mouse anti human CD16 and RPE conjugated mouse anti human CD88.
Product Details
MA5-28092
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
P12/1
Immunogen
C5aR peptide Met1-Asn31
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Lyophilized
Purification
Protein G
Storage buffer
PBS with 5% sucrose, 1% BSA
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2745081
Product Specific Information
Mouse anti Human CD88 antibody, clone P12/1 recognizes the C5a receptor (C5aR) also known as CD88 or C5a anaphylatoxin chemotactic receptor 1.
Reconstitute with 1.0 mL distilled water.
Target Information
CD88, also known as C5aR1, is a C5a Anaphylatoxin Receptor that mediates the effects of one of the most potent chemotactic agents known. C5AR1 has been implicated in asthma, and its expression has been reported in myeloid blood cells, brain, liver, lung, spleen, heart, kidney, and intestinal tract. CD88 is the receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. Functionally, CD88 stimulates chemotaxis, granule enzyme release and superoxide anion production. CD88 is also a component of the classical pathway of the complement cascade; it may be involved with tissue injury associated with ischemia or sepsis and it may be a component of the membrane attack complex. Diseases associated with CD88 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin receptor; C5a ligand; C5a Receptor; C5a-R; CD88; CD88 antigen; complement component 5 receptor 1
Gene Aliases: C5A; C5AR; C5AR1; C5R1; CD88
UniProt ID: (Human) P21730
Entrez Gene ID: (Human) 728
activation of MAPK activity
apoptotic process
chemotaxis
inflammatory response
immune response
cellular defense response
signal transduction
activation of phospholipase C activity
positive regulation of cytosolic calcium ion concentration
sensory perception of chemical stimulus
positive regulation of vascular endothelial growth factor production
positive regulation of macrophage chemotaxis
cell proliferation in hindbrain
regulation of complement activation
neutrophil chemotaxis
organ regeneration
response to peptidoglycan
response to lipopolysaccharide
complement component C5a signaling pathway
mRNA transcription from RNA polymerase II promoter
negative regulation of neuron apoptotic process
positive regulation of angiogenesis
positive regulation of epithelial cell proliferation
defense response to Gram-positive bacterium
positive regulation of ERK1 and ERK2 cascade
positive regulation of neutrophil chemotaxis
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