Product References
Reversing lysosome-ribosome circuit dysregulation mitigates C9FTD/ALS neurodegeneration and behaviors.
Human molecular genetics
Ma L,Liang C,Wang J,Chang Q,Wang Y,Zhang W,Du Y,Sadan J,Chen JF
Thu Apr 06 00:00:00 EDT 2023
C9ORF72 suppresses JAK-STAT mediated inflammation.
iScience
Pang W,Hu F
Fri May 19 00:00:00 EDT 2023
C9orf72 functions in the nucleus to regulate DNA damage repair.
Cell death and differentiation
He L,Liang J,Chen C,Chen J,Shen Y,Sun S,Li L
Wed Mar 01 00:00:00 EST 2023
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
Biochemical and biophysical research communications
Cang X,Wang Y,Zeng J,Gao J,Yu Q,Lu C,Xu F,Lin J,Zhu J,Wang X
Sat Jan 15 00:00:00 EST 2022
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
Biochemical and biophysical research communications
Cang X,Wang Y,Zeng J,Gao J,Yu Q,Lu C,Xu F,Lin J,Zhu J,Wang X
Sat Jan 15 00:00:00 EST 2022
C9orf72 knockdown alleviates hepatic insulin resistance by promoting lipophagy.
Biochemical and biophysical research communications
Cang X,Wang Y,Zeng J,Gao J,Yu Q,Lu C,Xu F,Lin J,Zhu J,Wang X
Sat Jan 15 00:00:00 EST 2022
Staufen1 in Human Neurodegeneration.
Annals of neurology
Paul S,Dansithong W,Figueroa KP,Gandelman M,Scoles DR,Pulst SM
Tue Jun 01 00:00:00 EDT 2021
Expression of C9orf72 hexanucleotide repeat expansion leads to formation of RNA foci and dipeptide repeat proteins but does not influence autophagy or proteasomal function in neuronal cells.
Biochimica et biophysica acta. Molecular cell research
Leskelä S,Huber N,Hoffmann D,Rostalski H,Remes AM,Takalo M,Hiltunen M,Haapasalo A
Tue Jun 01 00:00:00 EDT 2021
Ablation of C9orf72 together with excitotoxicity induces ALS in rats.
The FEBS journal
Dong W,Ma Y,Guan F,Zhang X,Chen W,Zhang L,Zhang L
Mon Mar 01 00:00:00 EST 2021
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.
Cell metabolism
Wang T,Liu H,Itoh K,Oh S,Zhao L,Murata D,Sesaki H,Hartung T,Na CH,Wang J
Tue Mar 02 00:00:00 EST 2021
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.
Cell metabolism
Wang T,Liu H,Itoh K,Oh S,Zhao L,Murata D,Sesaki H,Hartung T,Na CH,Wang J
Tue Mar 02 00:00:00 EST 2021
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.
Cell metabolism
Wang T,Liu H,Itoh K,Oh S,Zhao L,Murata D,Sesaki H,Hartung T,Na CH,Wang J
Tue Mar 02 00:00:00 EST 2021
C9orf72 regulates energy homeostasis by stabilizing mitochondrial complex I assembly.
Cell metabolism
Wang T,Liu H,Itoh K,Oh S,Zhao L,Murata D,Sesaki H,Hartung T,Na CH,Wang J
Tue Mar 02 00:00:00 EST 2021
G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Neuron
Coyne AN,Zaepfel BL,Hayes L,Fitchman B,Salzberg Y,Luo EC,Bowen K,Trost H,Aigner S,Rigo F,Yeo GW,Harel A,Svendsen CN,Sareen D,Rothstein JD
Wed Sep 23 00:00:00 EDT 2020
BV-2 Microglial Cells Overexpressing C9orf72 Hexanucleotide Repeat Expansion Produce DPR Proteins and Show Normal Functionality but No RNA Foci.
Frontiers in neurology
Rostalski H,Hietanen T,Leskelä S,Behánová A,Abdollahzadeh A,Wittrahm R,Mäkinen P,Huber N,Hoffmann D,Solje E,Remes AM,Natunen T,Takalo M,Tohka J,Hiltunen M,Haapasalo A
Sat Oct 31 00:00:00 EDT 2020
C9orf72/ALFA-1 controls TFEB/HLH-30-dependent metabolism through dynamic regulation of Rag GTPases.
PLoS genetics
Ji YJ,Ugolino J,Zhang T,Lu J,Kim D,Wang J
Wed Apr 01 00:00:00 EDT 2020
Analysis of ALS-related proteins during herpes simplex virus-2 latent infection.
Journal of neuroinflammation
Cabrera JR,Rodríguez-Izquierdo I,Jiménez JL,Muñoz-Fernández MÁ
Mon Dec 07 00:00:00 EST 2020
Analysis of ALS-related proteins during herpes simplex virus-2 latent infection.
Journal of neuroinflammation
Cabrera JR,Rodríguez-Izquierdo I,Jiménez JL,Muñoz-Fernández MÁ
Mon Dec 07 00:00:00 EST 2020
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.
Nature neuroscience
Zhu Q,Jiang J,Gendron TF,McAlonis-Downes M,Jiang L,Taylor A,Diaz Garcia S,Ghosh Dastidar S,Rodriguez MJ,King P,Zhang Y,La Spada AR,Xu H,Petrucelli L,Ravits J,Da Cruz S,Lagier-Tourenne C,Cleveland DW
Fri May 01 00:00:00 EDT 2020
C9orf72-associated SMCR8 protein binds in the ubiquitin pathway and with proteins linked with neurological disease.
Acta neuropathologica communications
Goodier JL,Soares AO,Pereira GC,DeVine LR,Sanchez L,Cole RN,García-Pérez JL
Thu Jul 16 00:00:00 EDT 2020
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.
eLife
Laflamme C,McKeever PM,Kumar R,Schwartz J,Kolahdouzan M,Chen CX,You Z,Benaliouad F,Gileadi O,McBride HM,Durcan TM,Edwards AM,Healy LM,Robertson J,McPherson PS
Tue Oct 15 00:00:00 EDT 2019
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.
eLife
Laflamme C,McKeever PM,Kumar R,Schwartz J,Kolahdouzan M,Chen CX,You Z,Benaliouad F,Gileadi O,McBride HM,Durcan TM,Edwards AM,Healy LM,Robertson J,McPherson PS
Tue Oct 15 00:00:00 EDT 2019
C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner.
Cells
Leskelä S,Huber N,Rostalski H,Natunen T,Remes AM,Takalo M,Hiltunen M,Haapasalo A
Thu Oct 10 00:00:00 EDT 2019
C9ORF72-related cellular pathology in skeletal myocytes derived from ALS-patient induced pluripotent stem cells.
Disease models & mechanisms
Lynch E,Semrad T,Belsito VS,FitzGibbons C,Reilly M,Hayakawa K,Suzuki M
Fri Aug 16 00:00:00 EDT 2019
C9ORF72-related cellular pathology in skeletal myocytes derived from ALS-patient induced pluripotent stem cells.
Disease models & mechanisms
Lynch E,Semrad T,Belsito VS,FitzGibbons C,Reilly M,Hayakawa K,Suzuki M
Fri Aug 16 00:00:00 EDT 2019
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.
Nature medicine
Shi Y,Lin S,Staats KA,Li Y,Chang WH,Hung ST,Hendricks E,Linares GR,Wang Y,Son EY,Wen X,Kisler K,Wilkinson B,Menendez L,Sugawara T,Woolwine P,Huang M,Cowan MJ,Ge B,Koutsodendris N,Sandor KP,Komberg J,Vangoor VR,Senthilkumar K,Hennes V,Seah C,Nelson AR,Cheng TY,Lee SJ,August PR,Chen JA,Wisniewski N,Hanson-Smith V,Belgard TG,Zhang A,Coba M,Grunseich C,Ward ME,van den Berg LH,Pasterkamp RJ,Trotti D,Zlokovic BV,Ichida JK
Thu Mar 01 00:00:00 EST 2018
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.
Nature medicine
Shi Y,Lin S,Staats KA,Li Y,Chang WH,Hung ST,Hendricks E,Linares GR,Wang Y,Son EY,Wen X,Kisler K,Wilkinson B,Menendez L,Sugawara T,Woolwine P,Huang M,Cowan MJ,Ge B,Koutsodendris N,Sandor KP,Komberg J,Vangoor VR,Senthilkumar K,Hennes V,Seah C,Nelson AR,Cheng TY,Lee SJ,August PR,Chen JA,Wisniewski N,Hanson-Smith V,Belgard TG,Zhang A,Coba M,Grunseich C,Ward ME,van den Berg LH,Pasterkamp RJ,Trotti D,Zlokovic BV,Ichida JK
Thu Mar 01 00:00:00 EST 2018
Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
Acta neuropathologica
Saberi S,Stauffer JE,Jiang J,Garcia SD,Taylor AE,Schulte D,Ohkubo T,Schloffman CL,Maldonado M,Baughn M,Rodriguez MJ,Pizzo D,Cleveland D,Ravits J
Thu Mar 01 00:00:00 EST 2018
Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis.
Acta neuropathologica
Saberi S,Stauffer JE,Jiang J,Garcia SD,Taylor AE,Schulte D,Ohkubo T,Schloffman CL,Maldonado M,Baughn M,Rodriguez MJ,Pizzo D,Cleveland D,Ravits J
Thu Mar 01 00:00:00 EST 2018
A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress.
Genes & development
Liu Y,Wang T,Ji YJ,Johnson K,Liu H,Johnson K,Bailey S,Suk Y,Lu YN,Liu M,Wang J
Thu Nov 01 00:00:00 EDT 2018
A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress.
Genes & development
Liu Y,Wang T,Ji YJ,Johnson K,Liu H,Johnson K,Bailey S,Suk Y,Lu YN,Liu M,Wang J
Thu Nov 01 00:00:00 EDT 2018
A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress.
Genes & development
Liu Y,Wang T,Ji YJ,Johnson K,Liu H,Johnson K,Bailey S,Suk Y,Lu YN,Liu M,Wang J
Thu Nov 01 00:00:00 EDT 2018
A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress.
Genes & development
Liu Y,Wang T,Ji YJ,Johnson K,Liu H,Johnson K,Bailey S,Suk Y,Lu YN,Liu M,Wang J
Thu Nov 01 00:00:00 EDT 2018
Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Davidson YS,Robinson AC,Rollinson S,Pickering-Brown S,Xiao S,Robertson J,Mann DMA
Thu Feb 01 00:00:00 EST 2018
Immunohistochemical detection of C9orf72 protein in frontotemporal lobar degeneration and motor neurone disease: patterns of immunostaining and an evaluation of commercial antibodies.
Amyotrophic lateral sclerosis & frontotemporal degeneration
Davidson YS,Robinson AC,Rollinson S,Pickering-Brown S,Xiao S,Robertson J,Mann DMA
Thu Feb 01 00:00:00 EST 2018
Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers.
Acta neuropathologica communications
Frick P,Sellier C,Mackenzie IRA,Cheng CY,Tahraoui-Bories J,Martinat C,Pasterkamp RJ,Prudlo J,Edbauer D,Oulad-Abdelghani M,Feederle R,Charlet-Berguerand N,Neumann M
Fri Aug 03 00:00:00 EDT 2018
Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers.
Acta neuropathologica communications
Frick P,Sellier C,Mackenzie IRA,Cheng CY,Tahraoui-Bories J,Martinat C,Pasterkamp RJ,Prudlo J,Edbauer D,Oulad-Abdelghani M,Feederle R,Charlet-Berguerand N,Neumann M
Fri Aug 03 00:00:00 EDT 2018
Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers.
Acta neuropathologica communications
Frick P,Sellier C,Mackenzie IRA,Cheng CY,Tahraoui-Bories J,Martinat C,Pasterkamp RJ,Prudlo J,Edbauer D,Oulad-Abdelghani M,Feederle R,Charlet-Berguerand N,Neumann M
Fri Aug 03 00:00:00 EDT 2018
Novel antibodies reveal presynaptic localization of C9orf72 protein and reduced protein levels in C9orf72 mutation carriers.
Acta neuropathologica communications
Frick P,Sellier C,Mackenzie IRA,Cheng CY,Tahraoui-Bories J,Martinat C,Pasterkamp RJ,Prudlo J,Edbauer D,Oulad-Abdelghani M,Feederle R,Charlet-Berguerand N,Neumann M
Fri Aug 03 00:00:00 EDT 2018
C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress.
Molecular neurobiology
Maharjan N,Künzli C,Buthey K,Saxena S
Mon May 01 00:00:00 EDT 2017
C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress.
Molecular neurobiology
Maharjan N,Künzli C,Buthey K,Saxena S
Mon May 01 00:00:00 EDT 2017
C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress.
Molecular neurobiology
Maharjan N,Künzli C,Buthey K,Saxena S
Mon May 01 00:00:00 EDT 2017
C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress.
Molecular neurobiology
Maharjan N,Künzli C,Buthey K,Saxena S
Mon May 01 00:00:00 EDT 2017
C9orf72 is required for proper macrophage and microglial function in mice.
Science (New York, N.Y.)
O'Rourke JG,Bogdanik L,Yáñez A,Lall D,Wolf AJ,Muhammad AK,Ho R,Carmona S,Vit JP,Zarrow J,Kim KJ,Bell S,Harms MB,Miller TM,Dangler CA,Underhill DM,Goodridge HS,Lutz CM,Baloh RH
Fri Mar 18 00:00:00 EDT 2016
C9orf72 is required for proper macrophage and microglial function in mice.
Science (New York, N.Y.)
O'Rourke JG,Bogdanik L,Yáñez A,Lall D,Wolf AJ,Muhammad AK,Ho R,Carmona S,Vit JP,Zarrow J,Kim KJ,Bell S,Harms MB,Miller TM,Dangler CA,Underhill DM,Goodridge HS,Lutz CM,Baloh RH
Fri Mar 18 00:00:00 EDT 2016
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.
Science translational medicine
Burberry A,Suzuki N,Wang JY,Moccia R,Mordes DA,Stewart MH,Suzuki-Uematsu S,Ghosh S,Singh A,Merkle FT,Koszka K,Li QZ,Zon L,Rossi DJ,Trowbridge JJ,Notarangelo LD,Eggan K
Wed Jul 13 00:00:00 EDT 2016
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease.
Science translational medicine
Burberry A,Suzuki N,Wang JY,Moccia R,Mordes DA,Stewart MH,Suzuki-Uematsu S,Ghosh S,Singh A,Merkle FT,Koszka K,Li QZ,Zon L,Rossi DJ,Trowbridge JJ,Notarangelo LD,Eggan K
Wed Jul 13 00:00:00 EDT 2016
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
The EMBO journal
Sellier C,Campanari ML,Julie Corbier C,Gaucherot A,Kolb-Cheynel I,Oulad-Abdelghani M,Ruffenach F,Page A,Ciura S,Kabashi E,Charlet-Berguerand N
Wed Jun 15 00:00:00 EDT 2016
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death.
The EMBO journal
Sellier C,Campanari ML,Julie Corbier C,Gaucherot A,Kolb-Cheynel I,Oulad-Abdelghani M,Ruffenach F,Page A,Ciura S,Kabashi E,Charlet-Berguerand N
Wed Jun 15 00:00:00 EDT 2016
Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation.
Journal of anatomy
Ferguson R,Serafeimidou-Pouliou E,Subramanian V
Thu Dec 01 00:00:00 EST 2016
Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation.
Journal of anatomy
Ferguson R,Serafeimidou-Pouliou E,Subramanian V
Thu Dec 01 00:00:00 EST 2016
Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation.
Journal of anatomy
Ferguson R,Serafeimidou-Pouliou E,Subramanian V
Thu Dec 01 00:00:00 EST 2016
Dynamic expression of the mouse orthologue of the human amyotropic lateral sclerosis associated gene C9orf72 during central nervous system development and neuronal differentiation.
Journal of anatomy
Ferguson R,Serafeimidou-Pouliou E,Subramanian V
Thu Dec 01 00:00:00 EST 2016
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.
Acta neuropathologica communications
Sullivan PM,Zhou X,Robins AM,Paushter DH,Kim D,Smolka MB,Hu F
Wed May 18 00:00:00 EDT 2016
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway.
Acta neuropathologica communications
Sullivan PM,Zhou X,Robins AM,Paushter DH,Kim D,Smolka MB,Hu F
Wed May 18 00:00:00 EDT 2016
