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MA1-74328 recognizes the epitope specificity group B, similar to the M-11 antibody.
A suggested positive control for immunohistochemical applications is lung adenocarcinoma, serosal ovarian adenocarcinoma or urinary bladder adenocarcinoma tissue.
CA 125 determinant is present on a high molecular weight, mucin like glycoprotein of high molecular weight. CA 125 has been found on frozen sections of amnion and derivatives of coelomic and mullerian epithelium, including pleura, pericardium and peritoneum. In adult tissues, epithelial cells of fallopian tube, endometrium and endocervix; pancreas, colon, gall bladder, stomach, kidney, apocrine sweat gland and mammary gland. It is also found in mesothelial cell lining of pleura, pericardium and peritoneum. It is found in ovarian tumors of serous, endometrioid or clear cell types and adenocarcinomas of mullerian type.
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Protein Aliases: CA-125; ca-ovarian; CA125 ovarian cancer antigen; FLJ14303; MUC-16; Mucin-16; Ovarian cancer-related tumor marker CA125; Ovarian carcinoma antigen CA125
Gene Aliases: CA125; MUC16
UniProt ID: (Human) Q8WXI7
Entrez Gene ID: (Human) 94025
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