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Immunogen sequence: MADSSGQQG KGRRVQPQWS PPAGTQPCRL HLYNSLTRNK EVFIPQDGKK VTWYCCGPTV YDASHMGHAR SYISFDILRR VLKDYFKFDV FYCMNITDID DKIIKRARQN HLFEQYREKR PEAAQLLEDV QAALKPFSVK LNETTDPDKK QMLERIQHAV QLATEPLEKA VQSRLTGEEV NSCVEVLLEE AKDLLSDWLD STLGCDVTDN SIFSKLPKFW EGDFHRDMEA LNVLPPDVLT RVSEYVPEIV NFVQKIVDNG YGYVSNGSVY FDTAKFASSE KHSYGKLVPE AVGDQKALQE GEGDLSISAD RLSEKRSPND FALWKASKPG EPSWPCPWGK GRPGWHIECS AMAG (1-353 aa encoded by BC002880)
This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
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Protein Aliases: CysRS; cysteine translase; cysteine tRNA ligase 1, cytoplasmic; Cysteine--tRNA ligase, cytoplasmic; Cysteinyl-tRNA synthetase; cysteinyl-tRNA synthetase, cytoplasmic
Gene Aliases: CA3; CARS; CARS1; CYSRS; MGC:11246
UniProt ID: (Human) P49589, (Mouse) Q9ER72
Entrez Gene ID: (Human) 833, (Mouse) 27267
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