Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
Immunogen sequence: HGITQANELV NLTEFFVNHI LPDLKSANVN EFPVLKADGI KYIMIFRNQV PKEHLLVSIP LLINHLQAES IVVHTYAAHA LERLFTMRGP NNATLF
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; CSE1 chromosome segregation 1 like; CSE1 chromosome segregation 1-like; Exp2; Exportin-2; Importin-alpha re-exporter; MGC117283; MGC130036; MGC130037
Gene Aliases: CAS; CSE1; CSE1L; XPO2
UniProt ID: (Human) P55060
Entrez Gene ID: (Human) 1434
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support