Proteintech

CBLB Polyclonal Antibody

CBLB Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 20

CBLB Antibody (12781-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse colon tissue slide using 12781-1-AP (CBLB Antibody) at dilution of 1:50 (under 40x lens).

CBLB Antibody in Immunoprecipitation (IP)

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Product Details

12781-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-dependent

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CBLB Fusion Protein Ag3491 (1-352 aa encoded by BC032851)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MANSMNGRN PGGRGGNPRK GRILGIIDAI QDAVGPPKQA AADRRTVEKT WKLMDKVVRL CQNPKLQLKN SPPYILDILP DTYQHLRLIL SKYDDNQKLA QLSENEYFKI YIDSLMKKSK RAIRLFKEGK ERMYEEQSQD RRNLTKLSLI FSHMLAEIKA IFPNGQFQGD NFRITKADAA EFWRKFFGDK TIVPWKVFRQ CLHEVHQISS GLEAMALKST IDLTCNDYIS VFEFDIFTRL FQPWGSILRN WNFLAVTHPG YMAFLTYDEV KARLQKYSTK PGSYIFRLSC TRLGQWAIGY VTGDGNILQT IPHNKPLFQA LIDGSREGFY LYPDGRSYNP DLTGLCEPTP HDH (1-352 aa encoded by BC032851)

Target Information

This gene encodes a protein of unknown function. The protein contains a bromodomain, a sequence motif often found in transcriptional coactivators, and localizes to the nucleus in testis and several other cell types.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

miR-27b-3p Attenuates Muscle Atrophy by Targeting Cbl-b in Skeletal Muscles.

Biomolecules

Yang X,Li Z,Wang Z,Yu J,Ma M,Nie Q

Sun Jan 23 00:00:00 EST 2022

Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.

European journal of pharmacology

Chen HK,Li YZ,Ge AN,Zhu YB,Wu SJ,Bai X,Bai HH,Liu YN

Fri Apr 15 00:00:00 EDT 2022

Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice.

European journal of pharmacology

Chen HK,Li YZ,Ge AN,Zhu YB,Wu SJ,Bai X,Bai HH,Liu YN

Fri Apr 15 00:00:00 EDT 2022

Mechanism of Yangxinshi Intervention on Cardiac Fibrosis in Diabetic Cardiomyopathy Based on Network Pharmacology.

Evidence-based complementary and alternative medicine : eCAM

Kuang J,Wu K,Li W,Zhang X,Zhang H,Jia Z,Han Q,Tian X,Sun R,Lu Q,Liu Y

Sat Apr 30 00:00:00 EDT 2022

Ionic Liquid-Based Extraction System for In-Depth Analysis of Membrane Protein Complexes.

Analytical chemistry

Chu H,Zhao Q,Liu J,Yang K,Wang Y,Liu J,Zhang K,Zhao B,He H,Zheng Y,Zhong S,Liang Z,Zhang L,Zhang Y

Tue Jan 18 00:00:00 EST 2022

Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.

Frontiers in immunology

Monticone G,Huang Z,Csibi F,Leit S,Ciccone D,Champhekar AS,Austin JE,Ucar DA,Hossain F,Ibba SV,Boulares AH,Carpino N,Xu K,Majumder S,Osborne BA,Loh C,Miele L

Tue Sep 13 00:00:00 EDT 2022

Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.

Frontiers in immunology

Monticone G,Huang Z,Csibi F,Leit S,Ciccone D,Champhekar AS,Austin JE,Ucar DA,Hossain F,Ibba SV,Boulares AH,Carpino N,Xu K,Majumder S,Osborne BA,Loh C,Miele L

Tue Sep 13 00:00:00 EDT 2022

Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.

Frontiers in immunology

Monticone G,Huang Z,Csibi F,Leit S,Ciccone D,Champhekar AS,Austin JE,Ucar DA,Hossain F,Ibba SV,Boulares AH,Carpino N,Xu K,Majumder S,Osborne BA,Loh C,Miele L

Tue Sep 13 00:00:00 EDT 2022

Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses.

Frontiers in immunology

Monticone G,Huang Z,Csibi F,Leit S,Ciccone D,Champhekar AS,Austin JE,Ucar DA,Hossain F,Ibba SV,Boulares AH,Carpino N,Xu K,Majumder S,Osborne BA,Loh C,Miele L

Tue Sep 13 00:00:00 EDT 2022

Cbl-b deficiency prevents functional but not phenotypic T cell anergy.

The Journal of experimental medicine

Nguyen TTT,Wang ZE,Shen L,Schroeder A,Eckalbar W,Weiss A

Mon Jul 05 00:00:00 EDT 2021

Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway.

OncoTargets and therapy

BommaReddy RR,Patel R,Smalley T,Acevedo-Duncan M

Wed Apr 13 00:00:00 EDT 2022

Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway.

OncoTargets and therapy

BommaReddy RR,Patel R,Smalley T,Acevedo-Duncan M

Wed Apr 13 00:00:00 EDT 2022

Ubiquitination and functional modification of GluN2B subunit-containing NMDA receptors by Cbl-b in the spinal cord dorsal horn.

Science signaling

Zhang ZY,Bai HH,Guo Z,Li HL,Diao XT,Zhang TY,Yao L,Ma JJ,Cao Z,Li YX,Bai X,Chen HK,Suo ZW,Yang X,Hu XD

Tue Jun 30 00:00:00 EDT 2020

Bta-miR-223 Targeting CBLB Contributes to Resistance to Staphylococcus aureus Mastitis Through the PI3K/AKT/NF-κB Pathway.

Frontiers in veterinary science

Han S,Li X,Liu J,Zou Z,Luo L,Wu R,Zhao Z,Wang C,Shen B

Tue Nov 17 00:00:00 EST 2020

Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL).

Diabetes, metabolic syndrome and obesity : targets and therapy

Chen K,Wan X,Zhao L,Zhao S,Peng L,Yang W,Yuan J,Zhu L,Mo Z

Sun Apr 17 00:00:00 EDT 2022

Cbl Proto-Oncogene B (CBLB) c.197A>T Mutation Induces Mild Metabolic Dysfunction in Partial Type I Multiple Symmetric Lipomatosis (MSL).

Diabetes, metabolic syndrome and obesity : targets and therapy

Chen K,Wan X,Zhao L,Zhao S,Peng L,Yang W,Yuan J,Zhu L,Mo Z

Sun Apr 17 00:00:00 EDT 2022

NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection.

Journal of cellular and molecular medicine

Pu ZQ,Liu D,Lobo Mouguegue HPP,Jin CW,Sadiq E,Qin DD,Yu TF,Zong C,Chen JC,Zhao RX,Lin JY,Cheng J,Yu X,Li X,Zhang YC,Liu YT,Guan QB,Wang XD

Tue Dec 01 00:00:00 EST 2020

NR4A1 counteracts JNK activation incurred by ER stress or ROS in pancreatic β-cells for protection.

Journal of cellular and molecular medicine

Pu ZQ,Liu D,Lobo Mouguegue HPP,Jin CW,Sadiq E,Qin DD,Yu TF,Zong C,Chen JC,Zhao RX,Lin JY,Cheng J,Yu X,Li X,Zhang YC,Liu YT,Guan QB,Wang XD

Tue Dec 01 00:00:00 EST 2020

A multiple sclerosis-associated variant of CBLB links genetic risk with type I IFN function.

Journal of immunology (Baltimore, Md. : 1950)

Stürner KH,Borgmeyer U,Schulze C,Pless O,Martin R

Sat Nov 01 00:00:00 EDT 2014

A multiple sclerosis-associated variant of CBLB links genetic risk with type I IFN function.

Journal of immunology (Baltimore, Md. : 1950)

Stürner KH,Borgmeyer U,Schulze C,Pless O,Martin R

Sat Nov 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; Casitas B-lineage lymphoma b; Casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; E3 ubiquitin-protein ligase CBL-B; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; Signal transduction protein CBL-B

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Gene Aliases: AI429560; AI851073; Cbl-b; CBLB; Nbla00127; RNF56

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UniProt ID: (Human) Q13191, (Rat) Q8K4S7, (Mouse) Q3TTA7

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Entrez Gene ID: (Human) 868, (Rat) 171136, (Mouse) 208650

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Function(s)

phosphotyrosine binding ubiquitin-protein transferase activity signal transducer activity calcium ion binding protein binding zinc ion binding ligase activity protein kinase binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity damaged DNA-binding protein ligase metabolite interconversion enzyme

Process(es)

protein polyubiquitination NLS-bearing protein import into nucleus signal transduction cell surface receptor signaling pathway response to gravity response to hormone regulation of signaling positive regulation of T cell anergy immune response protein ubiquitination intracellular signal transduction T cell activation positive regulation of protein catabolic process negative regulation of alpha-beta T cell proliferation negative regulation of T cell receptor signaling pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CBLB Polyclonal Antibody

CBLB Antibody (12781-1-AP) in IHC (P)

Product Details

12781-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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