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CBS Antibody (CL488-67861) in Flow
1X10^6 HeLa cells were intracellularly stained with 0.4 µg CoraLite® Plus 488 Anti-Human CBS (CL488-67861, Clone:1E4F10) (red), or 0.4 µg Mouse IgG2b Isotype Control (CL488-66360-3, Clone: K11B8C4B5) (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer (PF00011-C).
Product Details
CL488-67861
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E4F10
Immunogen
Recombinant protein
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 0.5% BSA
Contains
0.05% ProClin 300
Storage conditions
-20° C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: VAWRLKNEIP NSHILDQYRN ASNPLAHYDT TADEILQQCD GKLDMLVASV GTGGTITGIA RKLKEKCPGC RIIGVDPEGS ILAEPEELNQ TEQTTYEVEG IGYDFIPTVL DRTVVDKWFK SNDEEAFTFA RMLIAQEGLL CGGSAGSTVA VAVKAAQELQ EGQRCVVILP DSVRNYMTKF LSDRWMLQKG FLKEEDLTEK KPWWWHLRVQ ELGLSAPLTV LPTITCGHTI EILREKGFDQ APVVDEAGVI LGMVTLGNML SSLLAGKVQP SDQVGKVIYK QFKQIRLTDT LGRLSHILEM DHFALVVHEQ IQYHSTGKSS QRQMVFGVVT AIDLLNFVAA QERDQK
Target Information
Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-thionase; Cystathionine beta-synthase; cystathionine-beta-synthase; Hemoprotein H-450; methylcysteine synthase; Serine sulfhydrase
Gene Aliases: CBS; HIP4
UniProt ID: (Human) P35520, (Rat) P32232
Entrez Gene ID: (Human) 875, (Rat) 24250
cystathionine beta-synthase activity
cysteine synthase activity
protein binding
oxygen binding
enzyme binding
heme binding
pyridoxal phosphate binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding
nitrite reductase (NO-forming) activity
carbon monoxide binding
nitric oxide binding
modified amino acid binding
S-adenosyl-L-methionine binding
lyase
metabolite interconversion enzyme
cysteine biosynthetic process from serine
L-serine metabolic process
L-serine catabolic process
cellular amino acid biosynthetic process
cysteine biosynthetic process via cystathionine
cysteine biosynthetic process
transsulfuration
L-cysteine catabolic process
DNA protection
homocysteine catabolic process
homocysteine metabolic process
oxidation-reduction process
hydrogen sulfide biosynthetic process
endochondral ossification
blood vessel remodeling
superoxide metabolic process
cerebellum morphogenesis
regulation of cGMP metabolic process
response to nutrient levels
negative regulation of apoptotic process
regulation of JUN kinase activity
regulation of blood vessel size
response to folic acid
maternal process involved in female pregnancy
cartilage development involved in endochondral bone morphogenesis
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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