Proteintech

CBX5 Polyclonal Antibody

CBX5 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CBX5 Antibody (11831-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using (Product # 11831-1-AP) (CBX5 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CBX5 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11831-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

ChIP assay (ChIP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CBX5 Fusion Protein Ag2403 (1-191 aa encoded by BC006821)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is a rabbit polyclonal antibody raised against a full-length human HP1A protein, and can reacts with the 28 kDa HP1A protein.

Immunogen sequence: MGKKTKRTA DSSSSEDEEE YVVEKVLDRR VVKGQVEYLL KWKGFSEEHN TWEPEKNLDC PELISEFMKK YKKMKEGENN KPREKSESNK RKSNFSNSAD DIKSKKKREQ SNDIARGFER GLEPEKIIGA TDSCGDLMFL MKWKDTDEAD LVLAKEANVK CPQIVIAFYE ERLTWHAYPE DAENKEKETA KS (1-191 aa encoded by BC006821)

Target Information

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing. It has been shown that mammalian methyltransferases that selectively methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, a family of heterochromatic adaptor molecules implicated in both gene silencing and supranucleosomal chromatin structure. High-affinity in vitro recognition of a methylated histone H3 peptide by HP1 requires a functional chromodomain. Thus, the HP1 chromodomain is a specific interaction motif for the methyl epitope on lysine-9 of histone H3. In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-null primary mouse fibroblasts but is restored after reintroduction of a catalytically active SUV39H1 HMTase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.

Oncogene

Li L,Wang X,Hu K,Liu X,Qiu L,Bai C,Cui Y,Wang B,Wang Z,Wang H,Cheng R,Hua J,Hai L,Wang M,Liu M,Song Z,Xiao C,Li B

Thu Jun 01 00:00:00 EDT 2023

ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.

Oncogene

Li L,Wang X,Hu K,Liu X,Qiu L,Bai C,Cui Y,Wang B,Wang Z,Wang H,Cheng R,Hua J,Hai L,Wang M,Liu M,Song Z,Xiao C,Li B

Thu Jun 01 00:00:00 EDT 2023

Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis.

Microbiology spectrum

Fan R,Zhou Y,Chen X,Zhong X,He F,Peng W,Li L,Wang X,Xu Y

Tue Feb 14 00:00:00 EST 2023

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

The Journal of experimental medicine

Ma L,Yu L,Jiang BC,Wang J,Guo X,Huang Y,Ren J,Sun N,Gao DS,Ding H,Lu J,Zhou H,Zou L,Gao Y,Wang L,Sun K,Ming Y,Meng Z,Tao YX,Yan M

Mon Dec 06 00:00:00 EST 2021

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

The Journal of experimental medicine

Ma L,Yu L,Jiang BC,Wang J,Guo X,Huang Y,Ren J,Sun N,Gao DS,Ding H,Lu J,Zhou H,Zou L,Gao Y,Wang L,Sun K,Ming Y,Meng Z,Tao YX,Yan M

Mon Dec 06 00:00:00 EST 2021

ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.

Cancer research

Zhang L,Huo Q,Ge C,Zhao F,Zhou Q,Chen X,Tian H,Chen T,Xie H,Cui Y,Yao M,Li H,Li J

Mon Jun 15 00:00:00 EDT 2020

ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.

Cancer research

Zhang L,Huo Q,Ge C,Zhao F,Zhou Q,Chen X,Tian H,Chen T,Xie H,Cui Y,Yao M,Li H,Li J

Mon Jun 15 00:00:00 EDT 2020

Triptolide Promotes Senescence of Prostate Cancer Cells Through Histone Methylation and Heterochromatin Formation.

Asian Pacific journal of cancer prevention : APJCP

Tamgue O,Lei M

Wed Sep 27 00:00:00 EDT 2017

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Nature communications

Yang G,Weng X,Zhao Y,Zhang X,Hu Y,Dai X,Liang P,Wang P,Ma L,Sun X,Hou L,Xu H,Fang M,Li Y,Jenuwein T,Xu Y,Sun A

Fri Mar 31 00:00:00 EDT 2017

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Nature communications

Yang G,Weng X,Zhao Y,Zhang X,Hu Y,Dai X,Liang P,Wang P,Ma L,Sun X,Hou L,Xu H,Fang M,Li Y,Jenuwein T,Xu Y,Sun A

Fri Mar 31 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: Antigen p25; Cbx5 antibody; chromobox homolog 5; chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox protein homolog 5; epididymis luminal protein 25; heterochromatin protein 1 alpha; Heterochromatin protein 1 homolog alpha; heterochromatin protein 1-alpha; HGNC:1555; HP-1 alpha antibody; HP1 alpha; HP1 alpha homolog; HP1-ALPHA; HP1Hs alpha; HP1Hs-alpha; mHP1(alpha)

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Gene Aliases: 2610029O15Rik; C75991; CBX5; HEL25; HP1; HP1A; Hp1alpha

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UniProt ID: (Human) P45973, (Mouse) Q61686

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Entrez Gene ID: (Human) 23468, (Rat) 300266, (Mouse) 12419

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Function(s)

chromatin binding protein binding protein binding, bridging methylated histone binding protein homodimerization activity histone deacetylase binding repressing transcription factor binding molecular_function

Process(es)

biological_process negative regulation of transcription, DNA-templated blood coagulation viral process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CBX5 Polyclonal Antibody

CBX5 Antibody (11831-1-AP) in IHC (P)

Product Details

11831-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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