Abnova

CCL19 Monoclonal Antibody (3E9)

View all (23) CCL19 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00006363-M03A

Applications
Tested Dilution
Publications

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgM, kappa

Class

Monoclonal

Type

Antibody

Clone

3E9

Immunogen

CCL19 (AAH27968, 1 a.a. approximately 98 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL IKDGCRVPAV VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS

Target Information

CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC- subfamily of chemokines. It is most closely related to CCL21, with which it shares 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes. They are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into the secondary lymphoid organs. CCL19 and CCL21 also play a role in T cell priming and activation, as well as the recruitment of lymphocytes to inflamed tissue. Both proteins signal via the G protein-coupled receptor, CCR7, which is expressed on T cells and mature dendritic cells. Although CCL19 and CCL21 both exhibit the same affinity for CCR7, only the binding of CCL19 results in the desensitization and internalization of the receptor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: beta chemokine exodus-3; Beta-chemokine exodus-3; C-C motif chemokine; C-C motif chemokine 19; CC chemokine ligand 19; chemokine (C-C motif) ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; Epstein-Barr virus-induced molecule 1 ligand chemokine; exodus-3; M-MIP-3-beta; Macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; MIP-3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; Small-inducible cytokine A19

View more View less

Gene Aliases: CCL19; CKb11; ELC; MIP-3b; MIP3B; SCYA19

View more View less

UniProt ID: (Human) Q99731

View more View less

Entrez Gene ID: (Human) 6363

View more View less

Function(s)
chemokine activity CCR7 chemokine receptor binding CCR10 chemokine receptor binding chemokine receptor binding CCR chemokine receptor binding cytokine intercellular signal molecule
Process(es)
establishment of T cell polarity immunological synapse formation dendritic cell chemotaxis myeloid dendritic cell chemotaxis monocyte chemotaxis positive regulation of dendritic cell antigen processing and presentation cellular calcium ion homeostasis inflammatory response immune response cell communication G-protein coupled receptor signaling pathway activation of JUN kinase activity response to virus positive regulation of glycoprotein biosynthetic process T cell costimulation positive regulation of interleukin-12 production positive regulation of tumor necrosis factor production response to prostaglandin E positive regulation of T cell proliferation positive regulation of NF-kappaB import into nucleus positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity positive regulation of T-helper 1 cell differentiation positive regulation of endocytosis positive regulation of protein kinase activity positive regulation of JNK cascade lymphocyte chemotaxis positive regulation of receptor-mediated endocytosis cell maturation positive regulation of interleukin-1 beta secretion positive regulation of chemotaxis release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling regulation of cell projection assembly chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor response to nitric oxide interleukin-12 secretion positive regulation of neutrophil chemotaxis mature conventional dendritic cell differentiation cellular response to virus negative regulation of leukocyte apoptotic process positive regulation of cell motility positive regulation of dendritic cell dendrite assembly
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support