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Product Details
MA5-23751
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
54111
Immunogen
E. coli-derived recombinant human CCL21/6Ckine Ser24-Pro134
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2610503
Product Specific Information
In Western blots, shows 100% cross-reactivity with recombinant human (rh) CCL24. Under reducing conditions, this antibody shows approximately 10-50% cross-reactivity with rhCCL2, 8, 13, 28, and rmCCL2. This antibody does not cross-react with rhCCL1, 3, 4, 5, 7, 9, 11, 14a, 15, 17, 18, 19, 20, 22, 23, 25, rmCCL1, 3, 4, 6, 7, 9, 11, 12, 19, 20, 21, 22, 24, 25, 28, or rrCCL20.
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 6 Ckine; 6Ckine; beta chemokine exodus-2; Beta-chemokine exodus-2; C-C motif chemokine 21; chemokine (C-C motif) ligand 21; Efficient Chemoattractant for Lymphocytes; secondary lymphoid tissue chemokine; Secondary lymphoid-tissue chemokine; SLC; small inducible cytokine subfamily A (Cys-Cys), member 21; Small-inducible cytokine A21
Gene Aliases: 6Ckine; CCL21; CKb9; ECL; SCYA21; SLC; TCA4; UNQ784/PRO1600
UniProt ID: (Human) O00585
Entrez Gene ID: (Human) 6366
establishment of T cell polarity
immunological synapse formation
positive regulation of cell-matrix adhesion
dendritic cell chemotaxis
monocyte chemotaxis
positive regulation of dendritic cell antigen processing and presentation
inflammatory response
immune response
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of glycoprotein biosynthetic process
positive regulation of actin filament polymerization
positive regulation of pseudopodium assembly
T cell costimulation
ruffle organization
positive regulation of cell adhesion mediated by integrin
response to prostaglandin E
mesangial cell-matrix adhesion
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of protein kinase activity
positive regulation of JNK cascade
lymphocyte chemotaxis
positive regulation of receptor-mediated endocytosis
cell maturation
positive regulation of chemotaxis
release of sequestered calcium ion into cytosol
positive regulation of filopodium assembly
positive regulation of protein kinase B signaling
cell chemotaxis
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
positive regulation of neutrophil chemotaxis
activation of GTPase activity
dendritic cell dendrite assembly
negative regulation of leukocyte tethering or rolling
negative regulation of leukocyte apoptotic process
positive regulation of cell motility
positive regulation of T cell migration
positive regulation of myeloid dendritic cell chemotaxis
negative regulation of dendritic cell dendrite assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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