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Invitrogen
CCL4 Monoclonal Antibody (46907)
Advanced Verification
This Antibody was verified by Neutralization to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 1
CCL4 Antibody (MA5-23742)
Neutralization antibody testing demonstrates the specificity of an antibody through a correlation between antibody binding and the activity of the target. Neutralization of mouse CCL4/MIP-1 beta by Product # MA5-23742 shows decrease in signal with increasing concentrations of CCL4 monoclonal antibody. {Neu}
Product Details
MA5-23742
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
46907
Immunogen
E. coli-derived recombinant mouse CCL4/MIP-1 beta Ala24-Asn92
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2609426
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACT-2; ACT2; C-C motif chemokine 4; Immune activation protein 2; Macrophage inflammatory protein 1-beta; MGC104418; MGC126025; MGC126026; MIP-1 beta; MIP-1-beta; MIP1-beta; MIP1beta; Protein H400; RP23-320E6.8; SIS-gamma; small inducible cytokine A4; Small-inducible cytokine A4
Gene Aliases: Act-2; AT744.1; Ccl4; MIP-1B; Mip1b; Scya4
UniProt ID: (Mouse) P14097
Entrez Gene ID: (Mouse) 20303
chemotaxis
inflammatory response
immune response
response to toxic substance
leukocyte chemotaxis
positive regulation of tumor necrosis factor production
cellular response to drug
positive regulation of vascular permeability
negative regulation by host of viral transcription
positive regulation of calcium-mediated signaling
positive regulation of calcium ion transport
positive regulation of natural killer cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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